Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Giulia Guarguaglini"'
Publikováno v:
Cells, Vol 13, Iss 16, p 1397 (2024)
The AurkA serine/threonine kinase is a key regulator of cell division controlling mitotic entry, centrosome maturation, and chromosome segregation. The microtubule-associated protein TPX2 controls spindle assembly and is the main AurkA regulator, con
Externí odkaz:
https://doaj.org/article/4db7a0f256614324aedbe0b026bcd806
Autor:
Laura Antonelli, Federica Polverino, Alexandra Albu, Aroj Hada, Italia A. Asteriti, Francesca Degrassi, Giulia Guarguaglini, Lucia Maddalena, Mario R. Guarracino
Publikováno v:
Scientific Data, Vol 10, Iss 1, Pp 1-12 (2023)
Abstract Detecting and tracking multiple moving objects in a video is a challenging task. For living cells, the task becomes even more arduous as cells change their morphology over time, can partially overlap, and mitosis leads to new cells. Differen
Externí odkaz:
https://doaj.org/article/d311cfec11364d8dace390af0c1bb1ce
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 5, p 4746 (2023)
Myc transcription factors are key regulators of many cellular processes, with Myc target genes crucially implicated in the management of cell proliferation and stem pluripotency, energy metabolism, protein synthesis, angiogenesis, DNA damage response
Externí odkaz:
https://doaj.org/article/0fded9612d154b43a245f7fd182dfd13
Autor:
Giacomo Janson, Alessandro Grottesi, Marco Pietrosanto, Gabriele Ausiello, Giulia Guarguaglini, Alessandro Paiardini
Publikováno v:
PLoS Computational Biology, Vol 15, Iss 12, p e1007219 (2019)
The most frequently used approach for protein structure prediction is currently homology modeling. The 3D model building phase of this methodology is critical for obtaining an accurate and biologically useful prediction. The most widely employed tool
Externí odkaz:
https://doaj.org/article/3ce97145313e404489004dd073fa08c1
Autor:
Dalila Boi, Fani Souvalidou, Davide Capelli, Federica Polverino, Grazia Marini, Roberta Montanari, Giorgio Pochetti, Angela Tramonti, Roberto Contestabile, Daniela Trisciuoglio, Patrizia Carpinelli, Camilla Ascanelli, Catherine Lindon, Alessandro De Leo, Michele Saviano, Roberto Di Santo, Roberta Costi, Giulia Guarguaglini, Alessandro Paiardini
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 23, p 13122 (2021)
Neuroblastoma is a severe childhood disease, accounting for ~10% of all infant cancers. The amplification of the MYCN gene, coding for the N-Myc transcription factor, is an essential marker correlated with tumor progression and poor prognosis. In neu
Externí odkaz:
https://doaj.org/article/95ae0f8e2a4a42f28065143f67055798
Autor:
Maria Di Bari, Vanessa Tombolillo, Francesco Alessandrini, Claudia Guerriero, Mario Fiore, Italia Anna Asteriti, Emilia Castigli, Miriam Sciaccaluga, Giulia Guarguaglini, Francesca Degrassi, Ada Maria Tata
Publikováno v:
Cells, Vol 10, Iss 7, p 1727 (2021)
Background: Glioblastoma multiforme (GBM) is characterized by several genetic abnormalities, leading to cell cycle deregulation and abnormal mitosis caused by a defective checkpoint. We previously demonstrated that arecaidine propargyl ester (APE), a
Externí odkaz:
https://doaj.org/article/4efaad0827cb4138b8b9aaf9c2272d2e
Publikováno v:
Biomolecules, Vol 11, Iss 4, p 567 (2021)
The conformational state of the activation loop (A-loop) is pivotal for the activity of most protein kinases. Hence, the characterization of the conformational dynamics of the A-loop is important to increase our understanding of the molecular process
Externí odkaz:
https://doaj.org/article/f4f5f6391f29447b963397af38f59de3
Autor:
Francesco D. Naso, Valentina Sterbini, Elena Crecca, Italia A. Asteriti, Alessandra D. Russo, Maria Giubettini, Enrico Cundari, Catherine Lindon, Alessandro Rosa, Giulia Guarguaglini
Publikováno v:
Cells, Vol 9, Iss 2, p 374 (2020)
The microtubule-associated protein TPX2 is a key mitotic regulator that contributes through distinct pathways to spindle assembly. A well-characterised function of TPX2 is the activation, stabilisation and spindle localisation of the Aurora-A kinase.
Externí odkaz:
https://doaj.org/article/51c8cc23659f472a908112c8041e8986
Autor:
Marco De Santis Puzzonia, Angela Maria Cozzolino, Germana Grassi, Francesca Bisceglia, Raffaele Strippoli, Giulia Guarguaglini, Franca Citarella, Benedetto Sacchetti, Marco Tripodi, Alessandra Marchetti, Laura Amicone
Publikováno v:
PLoS ONE, Vol 11, Iss 11, p e0167158 (2016)
In all mammals, the adult liver shows binucleated as well as mononucleated polyploid hepatocytes. The hepatic polyploidization starts after birth with an extensive hepatocyte binucleation and generates hepatocytes of several ploidy classes. While the
Externí odkaz:
https://doaj.org/article/693844ab456f4a3ab3cc6cc55604f9eb
Autor:
Luciana Mosca, Elisabetta Falvo, Pierpaolo Ceci, Elena Poser, Ilaria Genovese, Giulia Guarguaglini, Gianni Colotti
Publikováno v:
Applied Sciences, Vol 7, Iss 1, p 101 (2017)
The ability of ferritin to bind and deliver metals and metal-based drugs to human neuroblastoma SH-SY5Y cells was studied. We used heavy chain (H) ferritin-based metal-containing nanocarriers to test whether these constructs, which are able to cross
Externí odkaz:
https://doaj.org/article/c73df262e3564987a80a026e246636c5