AT1-receptor blockade: Protective effects of irbesartan in cardiomyocytes under hypoxic stress.

Autor: Mariarosaria Boccellino, Marina Di Domenico, Maria Donniacuo, Giuseppe Bitti, Giulia Gritti, Pasqualina Ambrosio, Lucio Quagliuolo, Barbara Rinaldi

Publikováno v: PLoS ONE, Vol 13, Iss 10, p e0202297 (2018)

Hypoxia induces myocardial injury through the activation of inflammatory and oxidative processes. The pivotal role of the renin angiotensin system (RAS) in the pathogenesis of cardiovascular diseases has been firmly established in clinical trials and

Externí odkaz: https://doaj.org/article/f0d68552eccd49fcab6d3cf587281d9e

Effects of sildenafil on the gastrocnemius and cardiac muscles of rats in a model of prolonged moderate exercise training.

Autor: Barbara Rinaldi, Maria Donniacuo, Loredana Sodano, Giulia Gritti, Simona Signoriello, Elisabetta Parretta, Liberato Berrino, Konrad Urbanek, Annalisa Capuano, Francesco Rossi

Publikováno v: PLoS ONE, Vol 8, Iss 7, p e69954 (2013)

Moderate exercise training improves energetic metabolism, tissue perfusion and induces cardiac and skeletal muscle remodeling. Sildenafil, a potent phosphodiesterase-5 inhibitor used to treat erectile dysfunction, reduces infarct size and increases t

Externí odkaz: https://doaj.org/article/a33ba69c381749b48404ab2ebf2bb748

Adult cardiac stem cells are multipotent and robustly myogenic: c-kit expression is necessary but not sufficient for their identification

Autor: Bernardo Nadal-Ginard, Teresa Mancuso, Carla Vicinanza, Liam Couch, Pierangelo Veltri, Mariangela Scalise, Domenico Britti, Georgina M. Ellison-Hughes, Francesca Cristiano, Andrew J. Smith, Cesare M. Terracciano, Eleonora Cianflone, Pina Marotta, Victoria Shone, Walter Sacco, Daniele Torella, Fiona C. Lewis, Iolanda Aquila, Fabiola Marino, Ciro Indolfi, Annalaura Torella, Giulia Gritti

Publikováno v: Vicinanza, C, Aquila, I, Scalise, M, Cristiano, F, Marino, F, Cianflone, E, Mancuso, T, Marotta, P, Sacco, W, Lewis, F C, Couch, L, Shone, V, Gritti, G, Torella, A, Smith, A J, Terracciano, C M, Britti, D, Veltri, P, Indolfi, C, Nadal-Ginard, B, Ellison-Hughes, G & Torella, D 2017, ' Adult cardiac stem cells are multipotent and robustly myogenic : c-kit expression is necessary but not sufficient for their identification ', CELL DEATH AND DIFFERENTIATION, vol. 24, no. 12, pp. 2101-2116 . https://doi.org/10.1038/cdd.2017.130
Cell Death and Differentiation

Multipotent adult resident cardiac stem cells (CSCs) were first identified by the expression of c-kit, the stem cell factor receptor. However, in the adult myocardium c-kit alone cannot distinguish CSCs from other c-kit-expressing (c-kitpos) cells. T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6394ca0cb91889bd77800d365b0f3716
https://doi.org/10.1038/cdd.2017.130

Role of statins and mevalonate pathway on impaired HDAC2 activity induced by oxidative stress in human airway epithelial cells

Autor: Paola Rogliani, Maria Donniacuo, Laura Gallo, Maria Gabriella Matera, Mario Cazzola, Luigino Calzetta, Barbara Rinaldi, Giulia Gritti, Brunella Perfetto, Giovanna Donnarumma

In patients with chronic obstructive pulmonary disease (COPD) the inflammatory response is often steroid-resistant, likely since oxidative stress and cigarette smoking impair histone deacetylase 2 (HDAC2) activity. Since it has been demonstrated that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a99b49a7fe31813e84e241c62fdaed0e
http://hdl.handle.net/11591/398750

Effects of chronic treatment with the new ultra-long-acting β2-adrenoceptor agonist indacaterol alone or in combination with the β1-adrenoceptor blocker metoprolol on cardiac remodelling

Autor: Luigino Calzetta, Maria Donniacuo, Loredana Sodano, Augusto Orlandi, Eugenio Martuscelli, Annalisa Capuano, Giulia Gritti, Francesco Rossi, Concetta Rafaniello, Barbara Rinaldi, Maria Gabriella Matera

Publikováno v: British Journal of Pharmacology. 172:3627-3637

Background and Purpose The ability of a chronic treatment with indacaterol, a new ultra-long-acting β2-adrenoceptor agonist, to reverse cardiac remodelling and its effects in combination with metoprolol, a selective β1-adrenoceptor antagonist, were

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9cf5aea8a6d365122ff82bb52ca82252
https://doi.org/10.1111/bph.13148