Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Giulia Giandalia"'
Publikováno v:
Current Pharmaceutical Design. 18:5405-5410
The aim of this study was to investigate the potential for systemic administration of Methimazole (MMI) through the buccal mucosa as an alternative route for drug delivery. Considering that the most important restriction in buccal drug delivery could
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79ed96eb70f23b39e9f3925dca0a5eeb
https://doi.org/10.2174/138161212803307563
https://doi.org/10.2174/138161212803307563
Autor:
Maria Gabriella Siragusa, Vito Marcianò, Domenico Compilato, Fabio Bucchieri, Giulia Giandalia, Antonella Marino Gammazza, Viviana De Caro, Libero Italo Giannola, Giovanni Zummo, Alessandro Pitruzzella, Donna E. Davies, Alberto Fucarino, Carlo Paderni, Stephen T. Holgate, Felicia Farina, Giuseppina Campisi
Publikováno v:
Current Pharmaceutical Design. 18:5411-5420
Since the activity of several conventional anticancer drugs is restricted by resistance mechanisms and dose-limiting side-effects, the design of formulations for local application on malignant lesions seems to be an efficient and promising drug deliv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c47e6e906249b1a51a245f551605b987
https://doi.org/10.2174/138161212803307536
https://doi.org/10.2174/138161212803307536
Autor:
Maria Gabriella Siragusa, Flavia Maria Sutera, Libero Italo Giannola, V. De Caro, Giulia Giandalia
Publikováno v:
International Journal of Pharmaceutics. 429:78-83
The aptitude of ropinirole to permeate the buccal tissue was tested using porcine mucosa mounted on Franz-type diffusion cells as ex vivo model. Drug permeation was also evaluated in presence of various penetration enhancers and in iontophoretic cond
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb2714e2fabe558ebaed6e1d12f045c7
https://doi.org/10.1016/j.ijpharm.2012.03.022
https://doi.org/10.1016/j.ijpharm.2012.03.022
Autor:
Ada Maria Florena, Libero Italo Giannola, Giuseppina Campisi, Giulia Giandalia, Carlo Paderni, Maria Gabriella Siragusa, Viviana De Caro
Publikováno v:
Scopus-Elsevier
5-Fluorouracil (5-FU) is currently used for treatment of oral squamous cell carcinoma (OSCC). 5-FU is given by i.v. although the systemic administration is associated with severe toxic effects and no topical formulations of 5-FU for buccal drug deliv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::331eafef64c40566099ffd2d0dcfe66a
https://doi.org/10.2174/156720110791011792
https://doi.org/10.2174/156720110791011792
Autor:
Giulia Giandalia, Luisa Di Marzio, Libero Italo Giannola, Viviana De Caro, Carlotta Marianecci, E. Santucci, Maria Carafa
Publikováno v:
Journal of Liposome Research. 20:250-257
Dopamine delivery to the central nervous system (CNS) undergoes the permeability limitations of the blood-brain barrier (BBB). Condensation of dopamine with neutral amino acids could afford potential pro- drugs able to interact with the BBB endogenou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4206381c00118ea9e9dbb7a3370b467a
https://doi.org/10.3109/08982100903384129
https://doi.org/10.3109/08982100903384129
Autor:
Viviana De Caro, Giuseppina Campisi, Giulia Giandalia, Maria Gabriella Siragusa, Ada Maria Florena, Claudio Tripodo, Libero Italo Giannola
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 67:425-433
Transbuccal drug delivery has got several well-known advantages especially with respect to peroral way. Since a major limitation in buccal drug delivery could be the low permeability of the epithelium, the aptitude of NLX to penetrate the mucosal bar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c7e431e866f8e6171b023f55c558610
https://doi.org/10.1016/j.ejpb.2007.02.020
https://doi.org/10.1016/j.ejpb.2007.02.020
Autor:
E. Calderaro, Maria Brai, Giulia Giandalia, V. De Caro, Libero Italo Giannola, Monica Campisi, Antonio Bartolotta, Maria Cristina D'Oca
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 59:139-146
Ionizing radiation can be used as a drug sterilization technique, provided that the drug itself is not modified and that no toxic products are produced; moreover, if the irradiated product is a drug delivery system, the drug release characteristics m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c0e50409b69b1b39e9ed7ae7fb7c284
https://doi.org/10.1016/j.ejpb.2004.06.011
https://doi.org/10.1016/j.ejpb.2004.06.011
Autor:
Viviana De Caro, Fabio Carletti, Valerio Rizzo, Giuseppe Ferraro, Giulia Giandalia, Anna Lisa Scaturro, Libero Italo Giannola, Pierangelo Sardo, Simonetta Friscia
Publikováno v:
Journal of neural transmission (Vienna, Austria : 1996). 119(11)
N-valproyl-l-tryptophan (VPA-Tryp), new antiepileptic drug, was tested on CA1 hippocampal epileptiform bursting activity obtained by increasing potassium and lowering calcium and magnesium concentrations in the fluid perfusing rat brain slices. Each
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3386ce560feb8d913dbc9b47acf40f52
https://pubmed.ncbi.nlm.nih.gov/22573145
https://pubmed.ncbi.nlm.nih.gov/22573145
Autor:
Pierangelo Sardo, Viviana De Caro, Giuseppe Ferraro, Liliana Lamartina, Valerio Rizzo, Maria Gabriella Siragusa, Fabio Carletti, Simonetta Friscia, Giulia Giandalia, Libero Italo Giannola
Publikováno v:
Medicinal chemistry (Shariqah (United Arab Emirates)). 7(1)
A new aminoacidic derivative of valproic acid (VPA) has been synthesized and characterized by analytical and spectral data. The rationale for the preparation of such potential antiepileptic agent is based on the observation that chemical combination
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d80529da26dd35fd11003cf029f1bed2
https://pubmed.ncbi.nlm.nih.gov/21235514
https://pubmed.ncbi.nlm.nih.gov/21235514
Autor:
Giulia Giandalia, Liliana Lamartina, V. De Caro, Libero Italo Giannola, Maria Gabriella Siragusa
Publikováno v:
ChemInform. 40
Dopamine delivery to the central nervous system (CNS) undergoes the permeability limitations of blood-brain barrier (BBB) which is a selective interface that excludes most water-soluble molecules from entering the brain. Neutral amino acids permeate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f0377b39c4a91abe9a84bf806077e46b
https://doi.org/10.1002/chin.200903221
https://doi.org/10.1002/chin.200903221