Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Giulia Fragola"'
Autor:
Giulia Fragola, Angela M. Mabb, Bonnie Taylor-Blake, Jesse K. Niehaus, William D. Chronister, Hanqian Mao, Jeremy M. Simon, Hong Yuan, Zibo Li, Michael J. McConnell, Mark J. Zylka
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Topoisomerase 1 (TOP1) relieves DNA torsional stress during transcription and facilitates the expression of long neuronal genes. Here we show that deletion of Top1 in excitatory neurons leads to early onset neurodegeneration that is partially depende
Externí odkaz:
https://doaj.org/article/0fddde2332ce490c801aa1485380dfc3
Autor:
Brandon L. Pearson, Jeremy M. Simon, Eric S. McCoy, Gabriela Salazar, Giulia Fragola, Mark J. Zylka
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
This study presents gene expression responses of cultured brain cells to hundreds of chemicals found in the environment and in food. The authors identified chemicals that induce transcriptomic profiles that overlap those seen in human brains affected
Externí odkaz:
https://doaj.org/article/40eab20cb9c14472bd55674dbc22b4f9
Autor:
Giulia Fragola, Pierre-Luc Germain, Pasquale Laise, Alessandro Cuomo, Alessandro Blasimme, Fridolin Gross, Elena Signaroldi, Gabriele Bucci, Cesar Sommer, Giancarlo Pruneri, Giovanni Mazzarol, Tiziana Bonaldi, Gustavo Mostoslavsky, Stefano Casola, Giuseppe Testa
Publikováno v:
PLoS Genetics, Vol 9, Iss 2, p e1003292 (2013)
Transcription factor (TF)-induced reprogramming of somatic cells into induced pluripotent stem cells (iPSC) is associated with genome-wide changes in chromatin modifications. Polycomb-mediated histone H3 lysine-27 trimethylation (H3K27me3) has been p
Externí odkaz:
https://doaj.org/article/2c49370df92c4602afaa012c6b3686cd
Autor:
Mark J. Zylka, Angela M. Mabb, Bonnie Taylor-Blake, William D. Chronister, Jeremy M. Simon, Hong Yuan, Zibo Li, Michael J. McConnell, Giulia Fragola, Jesse K. Niehaus, Hanqian Mao
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Nature Communications
Nature Communications
Topoisomerase 1 (TOP1) relieves torsional stress in DNA during transcription and facilitates the expression of long (>100 kb) genes, many of which are important for neuronal functions. To evaluate how loss of Top1 affected neurons in vivo, we conditi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd9917856ceea64db8f49013740259b5
https://doaj.org/article/0fddde2332ce490c801aa1485380dfc3
https://doaj.org/article/0fddde2332ce490c801aa1485380dfc3
Autor:
Oleh Krupa, Giulia Fragola, Ellie Hadden-Ford, Jessica T. Mory, Tianyi Liu, Zachary Humphrey, Benjamin W. Rees, Ashok Krishnamurthy, William D. Snider, Mark J. Zylka, Guorong Wu, Lei Xing, Jason L. Stein
Tissue clearing methods allow every cell in the mouse brain to be imaged without physical sectioning. However, the computational tools currently available for cell quantification in cleared tissue images have been limited to counting sparse cell popu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::981501f55d5f74537aba8be7bc5ba555
https://doi.org/10.1101/2020.09.11.293399
https://doi.org/10.1101/2020.09.11.293399
Autor:
Jason L. Stein, Lei Xing, Tianyi Liu, Mark J. Zylka, Benjamin W. Rees, Guorong Wu, Oleh Krupa, Giulia Fragola, Jessica T. Mory, Ellie Hadden-Ford, Ashok Krishnamurthy, William D. Snider, Zachary Humphrey
Publikováno v:
Cell reports
SUMMARY Tissue-clearing methods allow every cell in the mouse brain to be imaged without physical sectioning. However, the computational tools currently available for cell quantification in cleared tissue images have been limited to counting sparse c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d2bcebc10aea1fdc0ea700290b91f8a
https://doi.org/10.1016/j.celrep.2021.109802
https://doi.org/10.1016/j.celrep.2021.109802
Autor:
Matthew P. Walker, Justin M. Wolter, Michael B. Major, Michael J. Emanuele, Mark J. Zylka, Jason J. Yi, Smita R. Paranjape, Rajarshi Choudhury, Giulia Fragola
Publikováno v:
Journal of Biological Chemistry. 292:12503-12515
UBE3A is a HECT domain E3 ubiquitin ligase whose dysfunction is linked to autism, Angelman syndrome, and cancer. Recently, we characterized a de novo autism-linked UBE3A mutant (UBE3AT485A) that disrupts phosphorylation control of UBE3A activity. Thr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::859717dd2ceacf9de70bc065153abe59
https://doi.org/10.1074/jbc.m117.788448
https://doi.org/10.1074/jbc.m117.788448
Autor:
Justin M. Wolter, Baris Oztemiz, Hannah O. Bazick, James L. Krantz, Hanqian Mao, Giulia Fragola, Jeremy M. Simon, Jason L. Stein, Mark J. Zylka
Publikováno v:
Nature
Angelman syndrome (AS) is a severe neurodevelopmental disorder caused by a mutation or deletion of the maternally inherited UBE3A allele. In neurons, the paternally inherited UBE3A allele is silenced in cis by a long non-coding RNA called UBE3A-ATS.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40883cd100a3582a9e85200490ff735d
https://pubmed.ncbi.nlm.nih.gov/33087932
https://pubmed.ncbi.nlm.nih.gov/33087932
Autor:
Ashok Krishnamurthy, Qian Wang, Jason L. Stein, Mike Conway, Shaoyu Wang, Vladimir Ghukasyan, Kira Bradford, Giulia Fragola, Erik Scott, Guorong Wu, Tianyi Liu, Zachary Humphrey, Mark J. Zylka, Xiaofeng Zhu
Publikováno v:
Patch-Based Techniques in Medical Imaging ISBN: 9783319674339
Patch-MI@MICCAI
Patch-MI@MICCAI
Recent innovations in tissue clearing and light sheet microscopy allow rapid acquisition of three-dimensional micron resolution images in fluorescently labeled brain samples. These data allow the observation of every cell in the brain, necessitating
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ef429f108ceee0f88dfe2f2d160601cd
https://doi.org/10.1007/978-3-319-67434-6_7
https://doi.org/10.1007/978-3-319-67434-6_7
Autor:
Eric S. McCoy, Gabriela Salazar, Mark J. Zylka, Jeremy M. Simon, Giulia Fragola, Brandon L. Pearson
Publikováno v:
Nature Communications
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
Environmental factors, including pesticides, have been linked to autism and neurodegeneration risk using retrospective epidemiological studies. Here we sought to prospectively identify chemicals that share transcriptomic signatures with neurological
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0c5dc26f720c316befeb8499c155830
https://doi.org/10.1038/ncomms11173
https://doi.org/10.1038/ncomms11173