Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Giulia Escobar"'
Autor:
Adele Mucci, Gabriele Antonarelli, Carolina Caserta, Francesco Maria Vittoria, Giacomo Desantis, Riccardo Pagani, Beatrice Greco, Monica Casucci, Giulia Escobar, Laura Passerini, Nico Lachmann, Francesca Sanvito, Matteo Barcella, Ivan Merelli, Luigi Naldini, Bernhard Gentner
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 10, Pp 1-18 (2021)
Abstract The immunosuppressive microenvironment surrounding tumor cells represents a key cause of treatment failure. Therefore, immunotherapies aimed at reprogramming the immune system have largely spread in the past years. We employed gene transfer
Externí odkaz:
https://doaj.org/article/4821b3ab509044fab1a533167e0978e3
Autor:
Giulia Escobar, Luigi Barbarossa, Giulia Barbiera, Margherita Norelli, Marco Genua, Anna Ranghetti, Tiziana Plati, Barbara Camisa, Chiara Brombin, Davide Cittaro, Andrea Annoni, Attilio Bondanza, Renato Ostuni, Bernhard Gentner, Luigi Naldini
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
An immune suppressive tumor microenvironment (TME) is a limitation for immunotherapy. Here the authors show that, in a B cell acute lymphoblastic leukemia mouse model, gene-based delivery of IFNα reprograms the leukemia-induced immunosuppressive TME
Externí odkaz:
https://doaj.org/article/d5447487f0d9463493bef78ed95681ca
Autor:
Mario Catarinella, Andrea Monestiroli, Giulia Escobar, Amleto Fiocchi, Ngoc Lan Tran, Roberto Aiolfi, Paolo Marra, Antonio Esposito, Federica Cipriani, Luca Aldrighetti, Matteo Iannacone, Luigi Naldini, Luca G Guidotti, Giovanni Sitia
Publikováno v:
EMBO Molecular Medicine, Vol 8, Iss 2, Pp 155-170 (2016)
Abstract Colorectal cancer (CRC) metastatic dissemination to the liver is one of the most life‐threatening malignancies in humans and represents the leading cause of CRC‐related mortality. Herein, we adopted a gene transfer strategy into mouse he
Externí odkaz:
https://doaj.org/article/72326cef96b64b368da85c5f40530022
Publikováno v:
Trends in Cancer. 8:642-654
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::926f1421abf76db9058318628fe1fb33
https://doi.org/10.1016/j.trecan.2022.04.003
https://doi.org/10.1016/j.trecan.2022.04.003
Autor:
Giulia Escobar, Katherine Tooley, Joan Pagès Oliveras, Cheng Hanning, Xue Chang, Davide Mangani, Hazel Natanael, Carola Rutigliani, Luca Biasco, Ana Carrizosa Anderson
Publikováno v:
Regular and Young Investigator Award Abstracts.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1608b1639bba656c3ed87d2d00e24f88
https://doi.org/10.1136/jitc-2022-sitc2022.0514
https://doi.org/10.1136/jitc-2022-sitc2022.0514
Autor:
Giulia Escobar, Katherine Tooley, Joan Pages Oliveras, Linglin Huang, Hanning Cheng, Chang Xue, Davide Mangani, Natanael Hazel, Carola Rutigliani, Luca Biasco, Ana C. Anderson
Publikováno v:
Cancer Research. 83:4157-4157
Stem-like CD8 T cells are regulated by the transcription factor TCF1 and are key players in the response to immune checkpoint blockade (ICB). However, recent findings indicate that the dependance on TCF1+ stem-like T cells for ICB efficacy may not be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d201b57397826dd9b4ab01325e38dca0
https://doi.org/10.1158/1538-7445.am2023-4157
https://doi.org/10.1158/1538-7445.am2023-4157
Autor:
Giulia Escobar, Katherine Tooley, Joan Pagès Oliveras, Cheng Hanning, Xue Chang, Davide Mangani, Hazel Natanael, Carola Rutigliani, Luca Biasco, Ana Carrizosa Anderson
Publikováno v:
Cancer Immunology Research. 10:B35-B35
Stem-like CD8 T cells that are regulated by the transcription factor TCF1 are key players in the response to immune checkpoint blockade (ICB). However, recent findings indicate that the dependance on TCF1+ stem-like T cells for ICB efficacy may not b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8f5a1951d236728adabf01a0f902d48d
https://doi.org/10.1158/2326-6074.tumimm22-b35
https://doi.org/10.1158/2326-6074.tumimm22-b35
Autor:
Orit Rozenblatt-Rosen, Katherine Tooley, Gitanjali Dandekar, Asaf Madi, Ana C. Anderson, Giulia Escobar, Aviv Regev, Conner Lambden, Livnat Jerby, Ella Goldschmidt
Unleashing cytotoxic CD8+ T cells for effective cancer treatment requires understanding T cell states across different tumor microenvironments. Here, we developed an algorithm to recover both shared and tumor type specific programs and used it to ana
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::92c6eb06bf4ad229e73b47187e3f2d2f
https://doi.org/10.1101/2021.10.31.466532
https://doi.org/10.1101/2021.10.31.466532
Publikováno v:
Science Immunology. 5
Recent advances have redefined a role for T cell factor 1 (TCF1) that goes beyond T cell development and T memory formation and encompasses new functions in the regulation of T cell biology. Here, we discuss the multifaceted and context-dependent rol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::788702989dd979707c921a10e656a285
https://doi.org/10.1126/sciimmunol.abb9726
https://doi.org/10.1126/sciimmunol.abb9726
Autor:
Giulia Escobar, Nandini Acharya, Meromit Singer, Huiyuan Zhang, Marcus Bosenberg, Vijay K. Kuchroo, Karen O. Dixon, Davide Mangani, Aviv Regev, Geoffrey Fell, Elena Christian, Junrong Xia, Donna Neuberg, Orit Rozenblatt-Rosen, Michelle Ferreira, Asaf Madi, Shai Dulberg, Katherine Tooley, Max Klapholz, Ana C. Anderson
Publikováno v:
PMC
Summary Identifying signals in the tumor microenvironment (TME) that shape CD8+ T cell phenotype can inform novel therapeutic approaches for cancer. Here, we identified a gradient of increasing glucocorticoid receptor (GR) expression and signaling fr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b28f52a69ee51295058c26393d17ad06
https://hdl.handle.net/1721.1/133832
https://hdl.handle.net/1721.1/133832