Intron retention and nuclear loss of SFPQ are molecular hallmarks of ALS

Autor: Raphaelle Luisier, Giulia E. Tyzack, Claire E. Hall, Jamie S. Mitchell, Helen Devine, Doaa M. Taha, Bilal Malik, Ione Meyer, Linda Greensmith, Jia Newcombe, Jernej Ule, Nicholas M. Luscombe, Rickie Patani

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)

Intron retention (IR) can increase protein diversity and function, and yet unregulated IR may be detrimental to cellular health. This study shows that aberrant IR occurs in ALS and finds nuclear loss of an RNA-binding protein called SFPQ as a new mol

Externí odkaz: https://doaj.org/article/9c63023a8964420da0433bba1c3207ac

A neuroprotective astrocyte state is induced by neuronal signal EphB1 but fails in ALS models

Autor: Giulia E. Tyzack, Claire E. Hall, Christopher R. Sibley, Tomasz Cymes, Serhiy Forostyak, Giulia Carlino, Ione F. Meyer, Giampietro Schiavo, Su-Chun Zhang, George M. Gibbons, Jia Newcombe, Rickie Patani, András Lakatos

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-17 (2017)

Astrocytes can have protective or detrimental effects on neurons during injury, but the molecular mechanisms that determine these different states are unresolved. Here the authors identify a pathway via neuronal EphB1 that induces neuroprotective sig

Externí odkaz: https://doaj.org/article/f2e3526b9f5c450291eab266e252c78a

Physiological intron retaining transcripts in the cytoplasm abound during human motor neurogenesis

Autor: Marija Petrić Howe, Hamish Crerar, Jacob Neeves, Jasmine Harley, Giulia E. Tyzack, Pierre Klein, Andres Ramos, Rickie Patani, Raphaëlle Luisier

Publikováno v: Genome Research.

Intron retention (IR) is now recognized as a dominant splicing event during motor neuron (MN) development; however, the role and regulation of intron-retaining transcripts (IRTs) localized to the cytoplasm remain particularly understudied. Here we sh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::969827fd0bfd567167a1942659da2d65
https://doi.org/10.1101/gr.276898.122

Astrocytes display cell autonomous and diverse early reactive states in familial amyotrophic lateral sclerosis

Autor: Doaa M Taha, Benjamin E Clarke, Claire E Hall, Giulia E Tyzack, Oliver J Ziff, Linda Greensmith, Bernadett Kalmar, Mhoriam Ahmed, Aftab Alam, Eric P Thelin, Nuria Marco Garcia, Adel Helmy, Christopher R Sibley, Rickie Patani

Publikováno v: Taha, D, Clarke, B, Hall, C, Tyzack, G, Ziff, O, Greensmith, L, Kalmar, B, Ahmed, M, Alam, A, Thelin, E P, Garcia, N, Helmy, A, Sibley, C R & Patani, R 2022, ' Astrocytes display cell autonomous and diverse early reactive states in familial amyotrophic lateral sclerosis ', Brain, vol. 145, no. 2, pp. 481-489 . https://doi.org/10.1093/brain/awab328

Amyotrophic lateral sclerosis is a rapidly progressive and fatal disease. Although astrocytes are increasingly recognized contributors to the underlying pathogenesis, the cellular autonomy and uniformity of astrocyte reactive transformation in differ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26c63121cb13970e6ca055888c04649a
https://www.pure.ed.ac.uk/ws/files/251644449/awab328.pdf

Automated and unbiased discrimination of ALS from control tissue at single cell resolution

Autor: Cathleen Hagemann, Raphaëlle Luisier, Giulia E. Tyzack, Linda Greensmith, Andrea Serio, Doaa M Taha, Rickie Patani, Jia Newcombe, Helen Devine

Publikováno v: Brain Pathology

Histopathological analysis of tissue sections is invaluable in neurodegeneration research. However, cell‐to‐cell variation in both the presence and severity of a given phenotype is a key limitation of this approach, reducing the signal to noise r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cacf5ce0ce5a1b5a3b587fa7b9fc49d
https://doi.org/10.1111/bpa.12937