Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Giulia De Conti"'
Autor:
Ziva Pogacar, Jackie L Johnson, Lenno Krenning, Giulia De Conti, Fleur Jochems, Cor Lieftink, Arno Velds, Leyma Wardak, Kelvin Groot, Arnout Schepers, Liqin Wang, Ji-Ying Song, Marieke van de Ven, Olaf van Tellingen, Rene H Medema, Roderick L Beijersbergen, Rene Bernards, Rodrigo Leite de Oliveira
Publikováno v:
PLoS ONE, Vol 17, Iss 9, p e0273182 (2022)
Inducing senescence in cancer cells is emerging as a new therapeutic strategy. In order to find ways to enhance senescence induction by palbociclib, a CDK4/6 inhibitor approved for treatment of metastatic breast cancer, we performed functional geneti
Externí odkaz:
https://doaj.org/article/6f29ef7b9b734b128186d1949fb65c09
Autor:
Fleur Jochems, Bram Thijssen, Giulia De Conti, Robin Jansen, Ziva Pogacar, Kelvin Groot, Liqin Wang, Arnout Schepers, Cun Wang, Haojie Jin, Roderick L. Beijersbergen, Rodrigo Leite de Oliveira, Lodewyk F.A. Wessels, René Bernards
Publikováno v:
Cell Reports, Vol 36, Iss 4, Pp 109441- (2021)
Summary: Cellular senescence is characterized as a stable proliferation arrest that can be triggered by multiple stresses. Most knowledge about senescent cells is obtained from studies in primary cells. However, senescence features may be different i
Externí odkaz:
https://doaj.org/article/e5885b546531426bb7c25ec795372518
Publikováno v:
Cancers, Vol 13, Iss 5, p 1118 (2021)
Designing specific therapies for drug-resistant cancers is arguably the ultimate challenge in cancer therapy. While much emphasis has been put on the study of genetic alterations that give rise to drug resistance, much less is known about the non-gen
Externí odkaz:
https://doaj.org/article/3b762ed69f7c47fd8229d3dfda206c68
Autor:
Giulia De Conti, Alicja M. Gruszka, Debora Valli, Andrea Umberto Cammarata, Matteo Righi, Massimiliano Mazza, Pier Giuseppe Pelicci
Publikováno v:
Cancers, Vol 12, Iss 12, p 3768 (2020)
The increased usage of high-throughput technologies in cancer research, including genetic and drug screens, generates large sets of candidate targets that need to be functionally validated for their roles in tumor development. Thus, reliable and robu
Externí odkaz:
https://doaj.org/article/55fafb28dbc14f79b893b567e7b1335c
Autor:
Matheus Henrique Dias, Anoek Friskes, Siying Wang, Joao M. Fernandes Neto, Frank van Gemert, Soufiane Mourragui, Hendrik J. Kuiken, Sara Mainardi, Daniel Alvarez-Villanueva, Cor Lieftink, Ben Morris, Anna Dekker, Emma van Dijk, Chrysa Papagianni, Marcelo S. da Silva, Robin Jansen, Antonio Mulero-Sánchez, Elke Malzer, August Vidal, Cristina Santos, Ramón Salazar, Rosangela A. M. Wailemann, Thompson E. P. Torres, Giulia De Conti, Jonne A. Raaijmakers, Petur Snaebjornsson, Shengxian Yuan, Wenxin Qin, John S. Kovach, Hugo A. Armelin, Hein te Riele, Alexander van Oudenaarden, Haojie Jin, Roderick L. Beijersbergen, Alberto Villanueva, Rene H. Medema, Rene Bernards
Cancer homeostasis depends on a balance between activated oncogenic pathways driving tumorigenesis and engagement of stress-response programs that counteract the inherent toxicity of such aberrant signaling. While inhibition of oncogenic signaling pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7a1e3875a49631c0a488ddbe547c772b
https://doi.org/10.1101/2023.02.06.527335
https://doi.org/10.1101/2023.02.06.527335
Autor:
Liqin Wang, Haojie Jin, Fleur Jochems, Siying Wang, Cor Lieftink, Isabel Mora Martinez, Giulia De Conti, Finn Edwards, Rodrigo Leite de Oliveira, Arnout Schepers, Yangyang Zhou, Jiaojiao Zheng, Wei Wu, Xingling Zheng, Shengxian Yuan, Jing Ling, Kathy Jastrzebski, Matheus Dos Santos Dias, Ji-Ying Song, Patrick N. H. Celie, Hideo Yagita, Ming Yao, Weiping Zhou, Roderick L. Beijersbergen, Wenxin Qin, René Bernards
Publikováno v:
Nature Cancer, 3(11), 1284-1299. Nature Research
Wang, L, Jin, H, Jochems, F, Wang, S, Lieftink, C, Martinez, I M, de Conti, G, Edwards, F, de Oliveira, R L, Schepers, A, Zhou, Y, Zheng, J, Wu, W, Zheng, X, Yuan, S, Ling, J, Jastrzebski, K, Santos Dias, M D, Song, J-Y, Celie, P N H, Yagita, H, Yao, M, Zhou, W, Beijersbergen, R L, Qin, W & Bernards, R 2022, ' cFLIP suppression and DR5 activation sensitize senescent cancer cells to senolysis ', Nature Cancer, vol. 3, no. 11, pp. 1284-1299 . https://doi.org/10.1038/s43018-022-00462-2
Wang, L, Jin, H, Jochems, F, Wang, S, Lieftink, C, Martinez, I M, de Conti, G, Edwards, F, de Oliveira, R L, Schepers, A, Zhou, Y, Zheng, J, Wu, W, Zheng, X, Yuan, S, Ling, J, Jastrzebski, K, Santos Dias, M D, Song, J-Y, Celie, P N H, Yagita, H, Yao, M, Zhou, W, Beijersbergen, R L, Qin, W & Bernards, R 2022, ' cFLIP suppression and DR5 activation sensitize senescent cancer cells to senolysis ', Nature Cancer, vol. 3, no. 11, pp. 1284-1299 . https://doi.org/10.1038/s43018-022-00462-2
Senolytics, drugs that kill senescent cells, have been proposed to improve the response to pro-senescence cancer therapies; however, this remains challenging due to a lack of broadly acting senolytic drugs. Using CRISPR/Cas9-based genetic screens in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a515cd48bd69c79c04ef44ba3703733
https://research.vumc.nl/en/publications/5cb78c17-95c0-4a56-91e6-59542f1c1a54
https://research.vumc.nl/en/publications/5cb78c17-95c0-4a56-91e6-59542f1c1a54
Autor:
René Bernards, Giulia De Conti, Lenno Krenning, Ziva Pogacar, Marieke van de Ven, Cor Lieftink, Arnout Schepers, Jackie Johnson, Arno Velds, Olaf van Tellingen, Kelvin Groot, Roderick L. Beijersbergen, Rodrigo Leite de Oliveira, Ji-Ying Song, Fleur Jochems, René H. Medema, Leyma Wardak, Liqin Wang
Publikováno v:
PLoS ONE, 17(9 September):e0273182. Public Library of Science
Pogacar, Z, Johnson, J L, Krenning, L, de Conti, G, Jochems, F, Lieftink, C, Velds, A, Wardak, L, Groot, K, Schepers, A, Wang, L, Song, J-Y, van de Ven, M, van Tellingen, O, Medema, R H, Beijersbergen, R L, Bernards, R & Leite de Oliveira, R 2022, ' Indisulam synergizes with palbociclib to induce senescence through inhibition of CDK2 kinase activity ', PLoS ONE, vol. 17, no. 9 September, e0273182, pp. e0273182 . https://doi.org/10.1371/journal.pone.0273182
Pogacar, Z, Johnson, J L, Krenning, L, de Conti, G, Jochems, F, Lieftink, C, Velds, A, Wardak, L, Groot, K, Schepers, A, Wang, L, Song, J-Y, van de Ven, M, van Tellingen, O, Medema, R H, Beijersbergen, R L, Bernards, R & Leite de Oliveira, R 2022, ' Indisulam synergizes with palbociclib to induce senescence through inhibition of CDK2 kinase activity ', PLoS ONE, vol. 17, no. 9 September, e0273182, pp. e0273182 . https://doi.org/10.1371/journal.pone.0273182
Inducing senescence in cancer cells is emerging as a new therapeutic strategy. In order to find ways to enhance senescence induction by palbociclib, a CDK4/6 inhibitor approved for treatment of metastatic breast cancer, we performed functional geneti
Autor:
Rodrigo Leite de Oliveira, Giulia De Conti, Cor Lieftink, Arnout Schepers, Roderick L. Beijersbergen, René Bernards, Ziva Pogacar, Fleur Jochems, Liqin Wang
Publikováno v:
Mol Cancer Res
Pro-senescence therapies are increasingly being considered for the treatment of cancer. Identifying additional targets to induce senescence in cancer cells could further enable such therapies. However, screening for targets whose suppression induces
Autor:
Cecilia Restelli, Giulia De Conti, Roman Hillje, Andrea Polazzi, Maria Elena Boggio Merlo, Giorgio Melloni, Lucilla Luzi, Emanuela Colombo, Pier Guiseppe Pelicci
Publikováno v:
Blood. 140:1279-1280
Autor:
Ziva Pogacar, Kelvin Groot, Fleur Jochems, Matheus Dos Santos Dias, Ben Morris, Mieke Roosen, Leyma Wardak, Giulia De Conti, Arno Velds, Cor Lieftink, Roderick L. Beijersbergen, René Bernards, Rodrigo Leite de Oliveira
Discovering biomarkers of drug response and finding powerful drug combinations can support the reuse of previously abandoned cancer drugs in the clinic. Indisulam is an abandoned drug that acts as a molecular glue, inducing degradation of splicing fa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::07406f3dd0e5b275179fb50e99060e7b
https://doi.org/10.1101/2021.12.20.473451
https://doi.org/10.1101/2021.12.20.473451