Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Giulia Culletta"'
Autor:
M. Akiful Haque, Akash Marathakam, Ritesh Rana, Samar J Almehmadi, Vishal B. Tambe, Manoj S. Charde, Fahadul Islam, Falak A. Siddiqui, Giulia Culletta, Anna Maria Almerico, Marco Tutone, Sharuk L. Khan
Publikováno v:
Molecules, Vol 28, Iss 2, p 501 (2023)
The present work describes the design and development of seventeen pyrimidine-clubbed benzimidazole derivatives as potential dihydrofolate reductase (DHFR) inhibitors. These compounds were filtered by using ADMET, drug-likeness characteristics calcul
Externí odkaz:
https://doaj.org/article/6190939685294e0bb355a7bcdf6a987b
Autor:
Mario Allegra, Marco Tutone, Luisa Tesoriere, Alessandro Attanzio, Giulia Culletta, Anna Maria Almerico
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Background: Indicaxanthin, a betaxanthin belonging to the betalain class of compounds, has been recently demonstrated to exert significant antiproliferative effects inducing apoptosis of human melanoma cells through the inhibition of NF-κB as the pr
Externí odkaz:
https://doaj.org/article/680010cce48644e7b17fc7c249d4b9f3
Publikováno v:
Pharmaceuticals, Vol 15, Iss 1, p 82 (2022)
Telomerase, a reverse transcriptase enzyme involved in DNA synthesis, has a tangible role in tumor progression. Several studies have evidenced telomerase as a promising target for developing cancer therapeutics. The main reason is due to the overexpr
Externí odkaz:
https://doaj.org/article/24b4a4d50f7c416d86734f422b9dee86
Publikováno v:
Molecules, Vol 26, Iss 13, p 4046 (2021)
The selective inhibition of immunoproteasome is a valuable strategy to treat autoimmune, inflammatory diseases, and hematologic malignancies. Recently, a new series of amide derivatives as non-covalent inhibitors of the β1i subunit with Ki values in
Externí odkaz:
https://doaj.org/article/3a71cdc7d7a94cc3b63ff20828046719
Autor:
Giulia Culletta, Maria Rita Gulotta, Ugo Perricone, Maria Zappalà, Anna Maria Almerico, Marco Tutone
Publikováno v:
Computation, Vol 8, Iss 3, p 77 (2020)
To date, SARS-CoV-2 infectious disease, named COVID-19 by the World Health Organization (WHO) in February 2020, has caused millions of infections and hundreds of thousands of deaths. Despite the scientific community efforts, there are currently no ap
Externí odkaz:
https://doaj.org/article/f53ecee9a4b245a988d577910469cfa8
Autor:
Zappalà, Giulia Culletta, Marco Tutone, Roberta Ettari, Ugo Perricone, Carla Di Chio, Anna Maria Almerico, Maria
Publikováno v:
International Journal of Molecular Sciences; Volume 24; Issue 13; Pages: 10504
Immunoproteasome inhibition is a promising strategy for the treatment of hematological malignancies, autoimmune diseases, and inflammatory diseases. The design of non-covalent inhibitors of the immunoproteasome β1i/β5i catalytic subunits could be a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::27d722987ae556c5b93334af0357d1ea
Autor:
Lentini, Pietro Salvatore Carollo, Marco Tutone, Giulia Culletta, Ignazio Fiduccia, Federica Corrao, Ivana Pibiri, Aldo Di Leonardo, Maria Grazia Zizzo, Raffaella Melfi, Andrea Pace, Anna Maria Almerico, Laura
Publikováno v:
International Journal of Molecular Sciences; Volume 24; Issue 11; Pages: 9609
Cystic Fibrosis (CF) is an autosomal recessive genetic disease caused by mutations in the CFTR gene, coding for the CFTR chloride channel. About 10% of the CFTR gene mutations are “stop” mutations that generate a premature termination codon (PTC)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::02572dabb4baa176d3e4760ea1d5c11b
Publikováno v:
Recent Advances in Inflammation & Allergy Drug Discovery. 17
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d58882c23a8a1d936ab4886351ed50a1
https://doi.org/10.2174/2772270817666230320124000
https://doi.org/10.2174/2772270817666230320124000
Publikováno v:
Current Drug Discovery Technologies. 17:740-747
Cyclin Dependent Kinases-2 (CDK2) are members of serine/threonine protein kinases family. They play an important role in the regulation events of the eukaryotic cell division cycle, especially during the G1 to S phase transition. Experimental evidenc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb9773a6fead91bccbd4112c25ec9a54
https://doi.org/10.2174/1570163816666190620113944
https://doi.org/10.2174/1570163816666190620113944
Autor:
Luisa Tesoriere, Anna Maria Almerico, Marco Tutone, Alessandro Attanzio, Giulia Culletta, Mario Allegra
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Frontiers in Pharmacology
Frontiers in Pharmacology
Background: Indicaxanthin, a betaxanthin belonging to the betalain class of compounds, has been recently demonstrated to exert significant antiproliferative effects inducing apoptosis of human melanoma cells through the inhibition of NF-κB as the pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::202cc68321814f324243011e574f1102
https://www.frontiersin.org/articles/10.3389/fphar.2021.701568/full
https://www.frontiersin.org/articles/10.3389/fphar.2021.701568/full