In vivo trafficking of a tumor-targeting IgE antibody: molecular imaging demonstrates rapid hepatobiliary clearance compared to IgG counterpart

Autor: Giulia Chiarruttini, Alexander Koers, Margaret S. Cooper, Francis Man, Panagiotis Karagiannis, Julia E. Blower, James Spicer, Amy E. Gilbert, Tihomir Dodev, Philip J. Blower, Jitesh Chauhan, Sophia N. Karagiannis, Silvia Mele, Silvia Crescioli, Heather J. Bax, Debra H. Josephs

Publikováno v: OncoImmunology, Vol 10, Iss 1 (2021)
Oncoimmunology
article-version (VoR) Version of Record
Man, F, Koers, A, Karagiannis, P, Josephs, D H, Bax, H J, Gilbert, A E, Dodev, T S, Mele, S, Chiarruttini, G, Crescioli, S, Chauhan, J, Blower, J E, Cooper, M S, Spicer, J, Karagiannis, S N & Blower, P J 2021, ' In vivo trafficking of a tumor-targeting IgE antibody : molecular imaging demonstrates rapid hepatobiliary clearance compared to IgG counterpart ', OncoImmunology, vol. 10, no. 1, 1966970 . https://doi.org/10.1080/2162402X.2021.1966970

IgE antibodies elicit powerful immune responses, recruiting effector cells to tumors more efficiently and with greater cytotoxicity than IgG antibodies. Consequently, IgE antibodies are a promising alternative to conventional IgG-based therapies in o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0856e17177e24d0a8d9af14a41fc2d39
https://doi.org/10.1080/2162402x.2021.1966970