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pro vyhledávání: '"Giulia Chiapparini"'
Autor:
Emmanuele Crespan, Antonia Furrer, Marcel Rösinger, Federica Bertoletti, Elisa Mentegari, Giulia Chiapparini, Ralph Imhof, Nathalie Ziegler, Shana J. Sturla, Ulrich Hübscher, Barbara van Loon, Giovanni Maga
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
Oxidative stress is a common source of DNA damage and is repaired by the base excision repair machinery, including polymerase beta. Here the authors find that polymerase beta, and to a lesser extent lambda, can mistakenly incorporate ribonucleotides
Externí odkaz:
https://doaj.org/article/763387984e1f4e0ab862ad33d073b020
Autor:
Ulrich Hübscher, Federica Bertoletti, Barbara van Loon, Emmanuele Crespan, Nathalie Ziegler, Giulia Chiapparini, Marcel Rösinger, Ralph Imhof, Giovanni Maga, Elisa Mentegari, Antonia Furrer, Shana J. Sturla
Publikováno v:
Nature Communications
Nature Communications, 7
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
Nature Communications, 7
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
Oxidative stress is a very frequent source of DNA damage. Many cellular DNA polymerases (Pols) can incorporate ribonucleotides (rNMPs) during DNA synthesis. However, whether oxidative stress-triggered DNA repair synthesis contributes to genomic rNMPs