Zobrazeno 1 - 10
of 153
pro vyhledávání: '"Giulia Casorati"'
Autor:
Elisa Landoni, Mark G. Woodcock, Gabriel Barragan, Gabriele Casirati, Vincenzo Cinella, Simone Stucchi, Leah M. Flick, Tracy A. Withers, Hanna Hudson, Giulia Casorati, Paolo Dellabona, Pietro Genovese, Barbara Savoldo, Leonid S. Metelitsa, Gianpietro Dotti
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Human natural killer T cells (NKTs) are innate-like T lymphocytes increasingly used for cancer immunotherapy. Here we show that human NKTs expressing the pro-inflammatory cytokine interleukin-12 (IL-12) undergo extensive and sustained molecu
Externí odkaz:
https://doaj.org/article/a48e168e6afd41a0a78d021d474cf617
Autor:
Elisa Landoni, Mark G. Woodcock, Gabriel Barragan, Gabriele Casirati, Vincenzo Cinella, Simone Stucchi, Leah M. Flick, Tracy A. Withers, Hanna Hudson, Giulia Casorati, Paolo Dellabona, Pietro Genovese, Barbara Savoldo, Leonid S. Metelitsa, Gianpietro Dotti
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/472487173e704ef3ad30fb9dddbe2c08
Autor:
Gloria Delfanti, Giulia Casorati
Publikováno v:
Bio-Protocol, Vol 13, Iss 13 (2023)
Invariant natural killer T (iNKT) cells are a non-conventional T-cell population expressing a conserved semi-invariant T-cell receptor (TCR) that reacts to lipid antigens, such as α-galactosyl ceramide (α-GalCer), presented by the monomorphic molec
Externí odkaz:
https://doaj.org/article/b124587583de44f6914cee22de6d6b67
Autor:
Michela Consonni, Claudio Garavaglia, Andrea Grilli, Claudia de Lalla, Alessandra Mancino, Lucia Mori, Gennaro De Libero, Daniela Montagna, Monica Casucci, Marta Serafini, Chiara Bonini, Daniel Häussinger, Fabio Ciceri, Massimo Bernardi, Sara Mastaglio, Silvio Bicciato, Paolo Dellabona, Giulia Casorati
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Leukaemia therapy may benefit from the use of antigens that are less restricted to individual donors. Here the authors engineered T cells with a TCR specific for a CD1c restricted lipid leukaemia antigen and show that they can protect against disease
Externí odkaz:
https://doaj.org/article/a21e6ce293244d2e824f24fa9452ea8d
Autor:
Noemi Alejandra Saavedra-Avila, Paolo Dellabona, Giulia Casorati, Natacha Veerapen, Gurdyal S. Besra, Amy R. Howell, Steven A. Porcelli
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Invariant natural killer T (iNKT) cells mediate immune responses when stimulated by glycolipid agonists presented by CD1d. In extensive studies of synthetic analogues of α-galactosyl ceramides, we identified numerous examples of significant differen
Externí odkaz:
https://doaj.org/article/5d32e342b826403ea225e6efd39248ae
Publikováno v:
Frontiers in Medicine, Vol 9 (2022)
Invariant Natural Killer T (iNKT) cells are T lymphocytes expressing a conserved semi-invariant TCR specific for lipid antigens (Ags) restricted for the monomorphic MHC class I-related molecule CD1d. iNKT cells infiltrate mouse and human tumors and p
Externí odkaz:
https://doaj.org/article/2c8ab870042b49b0b0aed3cb8000c6ea
Autor:
Maddalena Noviello, Francesco Manfredi, Eliana Ruggiero, Tommaso Perini, Giacomo Oliveira, Filippo Cortesi, Pantaleo De Simone, Cristina Toffalori, Valentina Gambacorta, Raffaella Greco, Jacopo Peccatori, Monica Casucci, Giulia Casorati, Paolo Dellabona, Masahiro Onozawa, Takanori Teshima, Marieke Griffioen, Constantijn J. M. Halkes, J. H. F. Falkenburg, Friedrich Stölzel, Heidi Altmann, Martin Bornhäuser, Miguel Waterhouse, Robert Zeiser, Jürgen Finke, Nicoletta Cieri, Attilio Bondanza, Luca Vago, Fabio Ciceri, Chiara Bonini
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Allogeneic hematopoietic cell transplantation is the standard treatment of acute myeloid leukemia, but many patients relapse. Here the authors show increased markers of exhaustion and cancer antigen specificity within bone marrow-residing memory T ce
Externí odkaz:
https://doaj.org/article/2409f0f6f05e4b0d801cc71746493996
Autor:
Bella Guerrouahen, Muhammad Elnaggar, Anjud Al-Mohannadi, Dhanya Kizhakayil, Chiara Bonini, Reuben Benjamin, Renier Brentjens, Christian J. Buchholz, Giulia Casorati, Soldano Ferrone, Frederick L. Locke, Francisco Martin, Axel Schambach, Cameron Turtle, Paul Veys, Hans J. van der Vliet, Cristina Maccalli, The EICCI Faculty Group
Publikováno v:
Frontiers in Immunology, Vol 11 (2021)
The progress in the isolation and characterization of tumor antigen (TA)-specific T lymphocytes and in the genetic modification of immune cells allowed the clinical development of adoptive cell therapy (ACT). Several clinical studies highlighted the
Externí odkaz:
https://doaj.org/article/ae47105da2384cf2aac3a940c8293fae
Autor:
Maya Fedeli, Mirela Kuka, Annamaria Finardi, Francesca Albano, Valentina Viganò, Matteo Iannacone, Roberto Furlan, Paolo Dellabona, Giulia Casorati
Publikováno v:
Clinical & Translational Immunology, Vol 10, Iss 9, Pp n/a-n/a (2021)
Abstract Objective miR‐21 is highly expressed in iNKT and activated T cells, but its T‐cell autonomous functions are poorly defined. We sought to investigate the role of miR‐21 in the development and functions of T and iNKT cells, representing
Externí odkaz:
https://doaj.org/article/6945cde2c3e2426a802bc123cb63abe9
Autor:
Annamaria Finardi, Martina Diceglie, Luca Carbone, Caterina Arnò, Alessandra Mandelli, Giuseppe De Santis, Maya Fedeli, Paolo Dellabona, Giulia Casorati, Roberto Furlan
Publikováno v:
Frontiers in Neurology, Vol 11 (2020)
MicroRNAs (miRNAs) are single-stranded RNA that have key roles in the development of the immune system and are involved in the pathogenesis of various autoimmune diseases. We previously demonstrated that two members of the miR106b-25 cluster and the
Externí odkaz:
https://doaj.org/article/95e13686da3f4c6987593afe804488a2