Identifying multiscale translational safety biomarkers using a network-based systems approach

Autor: Giulia Callegaro, Johannes P. Schimming, Janet Piñero González, Steven J. Kunnen, Lukas Wijaya, Panuwat Trairatphisan, Linda van den Berk, Kim Beetsma, Laura I. Furlong, Jeffrey J. Sutherland, Jennifer Mollon, James L. Stevens, Bob van de Water

Publikováno v: iScience, Vol 26, Iss 3, Pp 106094- (2023)

Summary: Animal testing is the current standard for drug and chemicals safety assessment, but hazards translation to human is uncertain. Human in vitro models can address the species translation but might not replicate in vivo complexity. Herein, we

Externí odkaz: https://doaj.org/article/c1ec17ac979040d09bc96f5bae7f9e91

The eTRANSAFE Project on Translational Safety Assessment through Integrative Knowledge Management: Achievements and Perspectives

Autor: François Pognan, Thomas Steger-Hartmann, Carlos Díaz, Niklas Blomberg, Frank Bringezu, Katharine Briggs, Giulia Callegaro, Salvador Capella-Gutierrez, Emilio Centeno, Javier Corvi, Philip Drew, William C. Drewe, José M. Fernández, Laura I. Furlong, Emre Guney, Jan A. Kors, Miguel Angel Mayer, Manuel Pastor, Janet Piñero, Juan Manuel Ramírez-Anguita, Francesco Ronzano, Philip Rowell, Josep Saüch-Pitarch, Alfonso Valencia, Bob van de Water, Johan van der Lei, Erik van Mulligen, Ferran Sanz

Publikováno v: Pharmaceuticals, Vol 14, Iss 3, p 237 (2021)

eTRANSAFE is a research project funded within the Innovative Medicines Initiative (IMI), which aims at developing integrated databases and computational tools (the eTRANSAFE ToxHub) that support the translational safety assessment of new drugs by usi

Externí odkaz: https://doaj.org/article/6d356b4a5992408987f2d8a0131d3981

Mapping the cellular response to electron transport chain inhibitors reveals selective signaling networks triggered by mitochondrial perturbation

Autor: Paul Jennings, Giada Carta, Johannes P Schimming, Erik H.J. Danen, Marcel Leist, Giulia Callegaro, Nanette G Vrijenhoek, Joost B. Beltman, Anna Forsby, Johannes Delp, Andrew White, Bob van de Water, Sylvia E. Le Dévédec, Huan Yang, Wanda van der Stel, Salihanur Darici

Publikováno v: van der Stel, W, Yang, H, Vrijenhoek, N G, Schimming, J P, Callegaro, G, Carta, G, Darici, S, Delp, J, Forsby, A, White, A, le Dévédec, S, Leist, M, Jennings, P, Beltman, J B, van de Water, B & Danen, E H J 2022, ' Mapping the cellular response to electron transport chain inhibitors reveals selective signaling networks triggered by mitochondrial perturbation ', Archives of Toxicology, vol. 96, no. 1, pp. 259-285 . https://doi.org/10.1007/s00204-021-03160-7
Archives of Toxicology, 96
Archives of Toxicology
Archives of Toxicology, 96(1), 259-285. Springer Verlag

Mitochondrial perturbation is a key event in chemical-induced organ toxicities that is incompletely understood. Here, we studied how electron transport chain (ETC) complex I, II, or III (CI, CII and CIII) inhibitors affect mitochondrial functionality

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31e5ec3b4fb4c6608dfe265e2934a630
https://hdl.handle.net/1871.1/e0b19077-5a27-48fb-bc1b-0dc3bbb415f8

The human hepatocyte TXG-MAPr: WGCNA transcriptomic modules to support mechanism-based risk assessment

Autor: Emre Guney, van de Water B, Julio Saez-Rodriguez, Laura I. Furlong, Steven J. Kunnen, Mollon J, den Hollander W, Giulia Callegaro, Janet Piñero Gonzalez, Yue Webster, Panuwat Trairatphisan, James L. Stevens, Solène Grosdidier, Jeffrey J. Sutherland, Marije Niemeijer

Mechanism-based risk assessment is urged to advance and fully permeate into current safety assessment practices, possibly at early phases of drug safety testing. Toxicogenomics is a promising source of comprehensive and mechanisms-revealing data, but

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c1eb37b5fdb99fe44d4150d637b7f307
https://doi.org/10.1101/2021.05.17.444463

In vitro and bioinformatics mechanistic-based approach for cadmium carcinogenicity understanding

Autor: P. Melchioretto, Giulia Callegaro, Matilde Forcella, Chiara Urani, Paola Fusi, Marco Fabbri, Monica Oldani, Laura Gribaldo

Publikováno v: Toxicology in Vitro

Cadmium is a toxic metal able to enter the cells through channels and transport pathways dedicated to essential ions, leading, among others, to the dysregulation of divalent ions homeostasis. Despite its recognized human carcinogenicity, the mechanis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::258fd5cf20aa23670c1546276a4bc4f5
http://hdl.handle.net/10281/270468