Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Giulia Bottoni"'
Autor:
Sandro Goruppi, Andrea Clocchiatti, Giulia Bottoni, Emery Di Cicco, Min Ma, Beatrice Tassone, Victor Neel, Shadhmer Demehri, Christian Simon, G. Paolo Dotto
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)
The identification of kinases that control epigenetic mechanisms in squamous cell carcinomas (SCCs) can be of therapeutic relevance. Here the authors show that loss of nuclear kinase ULK3 impairs the recruitment of two histone arginine methyltransfer
Externí odkaz:
https://doaj.org/article/5292438042014403911172968fc98647
Autor:
Atul Katarkar, Giulia Bottoni, Andrea Clocchiatti, Sandro Goruppi, Pino Bordignon, Francesca Lazzaroni, Ilaria Gregnanin, Paola Ostano, Victor Neel, G. Paolo Dotto
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
The presence of genomic alterations in cancer associated fibroblasts (CAFs) is largely unexplored. The authors show that frequent NOTCH1 gene amplification and overexpression render CAFs resistant to the UVA-induced DNA damage response (DDR) and prom
Externí odkaz:
https://doaj.org/article/50d8fbca5759425c9fb107d5441047f8
Autor:
Giulia Bottoni, Atul Katarkar, Beatrice Tassone, Soumitra Ghosh, Andrea Clocchiatti, Sandro Goruppi, Pino Bordignon, Paris Jafari, Fabio Tordini, Thomas Lunardi, Wolfram Hoetzenecker, Victor Neel, Joachim Lingner, G. Paolo Dotto
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Conversion of dermal fibroblasts into Cancer Associated Fibroblasts (CAFs) can play an important role in keratinocyte tumour development. Here the authors reveal that CSL plays a role in maintenance of telomeres and genomic integrity in both dermal f
Externí odkaz:
https://doaj.org/article/82b5056962d14041aae036cba6d017e3
Autor:
Pino Bordignon, Giulia Bottoni, Xiaoying Xu, Alma S. Popescu, Zinnia Truan, Emmanuella Guenova, Lukas Kofler, Paris Jafari, Paola Ostano, Martin Röcken, Victor Neel, G. Paolo Dotto
Publikováno v:
Cell Reports, Vol 28, Iss 9, Pp 2358-2372.e6 (2019)
Summary: Heterogeneity of cancer-associated fibroblasts (CAFs) can result from activation of distinct signaling pathways. We show that in primary human dermal fibroblasts (HDFs), fibroblast growth factor (FGF) and transforming growth factor β (TGF-
Externí odkaz:
https://doaj.org/article/16e7573a3e1445219de1a405631deb3f
Autor:
G. Paolo Dotto, Soumitra Ghosh, Pino Bordignon, Maria-Giuseppina Procopio, Atul Katarkar, Mitchell P. Levesque, Luigi Mazzeo, Andrea Clocchiatti, Victor A. Neel, Sandro Goruppi, Berna C. Özdemir, Giulia Bottoni, Paola Ostano, Peter Kölblinger, Reinhard Dummer
Publikováno v:
Journal of Clinical Investigation. 128:5531-5548
The aging-associated increase of cancer risk is linked with stromal fibroblast senescence and concomitant cancer-associated fibroblast (CAF) activation. Surprisingly little is known about the role of androgen receptor (AR) signaling in this context.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd1bfc740805a5caf063b398b1acdc9c
https://doi.org/10.1172/jci99159
https://doi.org/10.1172/jci99159
Autor:
Lidia Sacchetto, Ilaria Gregnanin, Marco Oderda, Giovanna Chiorino, Barbara Pardini, Andrea Zitella, Alessio Naccarati, Giancarlo Marra, Paolo Gontero, Giulia Bottoni, Maurizia Mello-Grand, Stefania Munegato, Paola Ostano, Mauro Gasparini
The dosage of prostate-specific antigen (PSA), an easily evaluable and non-invasive biomarker, has made early detection of prostate cancer (PCa) possible. However, it leads to high percentages of unnecessary biopsies and may miss aggressive tumors in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::990b2323c49fae974b64d9fd4014056f
http://hdl.handle.net/11583/2788199
http://hdl.handle.net/11583/2788199
Autor:
Pino Bordignon, Giulia Bottoni, Xiaoying Xu, Alma S. Popescu, Zinnia Truan, Emmanuella Guenova, Lukas Kofler, Paris Jafari, Paola Ostano, Martin Röcken, Victor Neel, G. Paolo Dotto
Publikováno v:
Cell Reports
Cell Reports, Vol 28, Iss 9, Pp 2358-2372.e6 (2019)
Cell Reports, Vol 28, Iss 9, Pp 2358-2372.e6 (2019)
Summary Heterogeneity of cancer-associated fibroblasts (CAFs) can result from activation of distinct signaling pathways. We show that in primary human dermal fibroblasts (HDFs), fibroblast growth factor (FGF) and transforming growth factor β (TGF-β
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::8ac3aa0565d6ff3736dfc7e41cd3f3a1
https://pubmed.ncbi.nlm.nih.gov/31461652
https://pubmed.ncbi.nlm.nih.gov/31461652
Autor:
Atul Katarkar, Giulia Bottoni, Andrea Clocchiatti, Sandro Goruppi, Pino Bordignon, Francesca Lazzaroni, Ilaria Gregnanin, Paola Ostano, Victor Neel, G. Paolo Dotto
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Cancer associated fibroblasts (CAFs) are a key component of the tumor microenvironment. Genomic alterations in these cells remain a point of contention. We report that CAFs from skin squamous cell carcinomas (SCCs) display chromosomal alterations, wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::00674319123dc73f943675fdc54dc1d3