Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Giulia Bianco"'
Autor:
Claudia Melis, Rita Meleddu, Andrea Angeli, Simona Distinto, Giulia Bianco, Clemente Capasso, Filippo Cottiglia, Rossella Angius, Claudiu T. Supuran, Elias Maccioni
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 32, Iss 1, Pp 68-73 (2017)
The isatin scaffold is the constitutive fragment of several natural and synthetic bioactive molecules. Albeit several benzene sulphonamide-based carbonic anhydrase inhibitors (CAIs) have been reported, only recently isatin benzene sulphonamides have
Externí odkaz:
https://doaj.org/article/8e3c55a9ca1043289f5af1d682be8f71
Autor:
Rita Meleddu, Simona Distinto, Roberto Cirilli, Stefano Alcaro, Matilde Yanez, Maria Luisa Sanna, Angela Corona, Claudia Melis, Giulia Bianco, Peter Matyus, Filippo Cottiglia, Elias Maccioni
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 32, Iss 1, Pp 264-270 (2017)
3,5-Diaryl-4,5-dihydroisoxazoles were synthesized and evaluated as monoamine oxidase (MAO) enzyme inhibitors and iron chelators. All compounds exhibited selective inhibitory activity towards the B isoform of MAO in the nanomolar concentration range.
Externí odkaz:
https://doaj.org/article/b07e5ad6ad8d40859a635f489a18d193
Autor:
Rita Meleddu, Simona Distinto, Angela Corona, Enzo Tramontano, Giulia Bianco, Claudia Melis, Filippo Cottiglia, Elias Maccioni
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 32, Iss 1, Pp 130-136 (2017)
A series of 3-3-{2-[2-3-methyl-4-phenyl-2,3-dihydro-1,3-thiazol-2-ylidene]hydrazin-1-ylidene-2,3-dihydro-1H-indol-2-one derivatives has been designed and synthesized to study their activity on both HIV-1 (Human Immunodeficiency Virus type 1) RT (Reve
Externí odkaz:
https://doaj.org/article/564986064205413cbaec4df85feab6cb
Autor:
Angela Corona, Rita Meleddu, Francesca Esposito, Simona Distinto, Giulia Bianco, Takashi Masaoka, Elias Maccioni, Luis Menéndez-Arias, Stefano Alcaro, Stuart F J Le Grice, Enzo Tramontano
Publikováno v:
PLoS ONE, Vol 11, Iss 1, p e0147225 (2016)
The DNA polymerase and ribonuclease H (RNase H) activities of human immunodeficiency virus type 1 (HIV-1) are needed for the replication of the viral genome and are validated drug targets. However, there are no approved drugs inhibiting RNase H and t
Externí odkaz:
https://doaj.org/article/d990758b6bec47228f7c81f5c7d4f13a
Autor:
Giulia Bianco, Matthew Holcomb, Diogo Santos-Martins, Andreas Tillack, Althea Hansel-Harris, Stefano Forli
We describe the formalization of the reactive docking protocol, a method developed to model and predict reactions between small molecules and biological macromolecules. The method has been successfully used in a number of applications already, includ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7780ef9d6123710a3529710e0a989cf2
https://doi.org/10.26434/chemrxiv-2023-19v1v
https://doi.org/10.26434/chemrxiv-2023-19v1v
Autor:
Yunfei Cheng, Gencheng Li, Christopher J. Smedley, Marie-Claire Giel, Seiya Kitamura, Jordan L. Woehl, Giulia Bianco, Stefano Forli, Joshua A. Homer, John R. Cappiello, Dennis W. Wolan, John E. Moses, K. Barry Sharpless
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(37)
Diversity Oriented Clicking (DOC) is a discovery method geared toward the rapid synthesis of functional libraries. It combines the best attributes of both classical and modern click chemistries. DOC strategies center upon the chemical diversification
Autor:
Yunfei Cheng, Gencheng Li, Christopher J. Smedley, Marie-Claire Giel, Seiya Kitamura, Jordan L. Woehl, Giulia Bianco, Stefano Forli, Joshua A. Homer, John R. Cappiello, Dennis W. Wolan, John E. Moses, K. Barry Sharpless
Diversity Oriented Clicking (DOC) is a discovery method geared towards the rapid synthesis of functional libraries. It combines the best attributes of both classical and modern click chemistries. DOC strategies center upon the chemical diversificatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4802362397d21809a5ca8c9efe873c08
https://doi.org/10.26434/chemrxiv-2022-4dc71
https://doi.org/10.26434/chemrxiv-2022-4dc71
Autor:
Stefano Forli, Francesca Alessandra Ambrosio, Andreas Koch, Leonardo Solis-Vasquez, Giulia Bianco, Jerome Eberhardt, Diogo Santos-Martins
Publikováno v:
J Comput Aided Mol Des
In this paper we describe our approaches to predict the binding mode of twenty BACE1 ligands as part of Grand Challenge 4 (GC4), organized by the Drug Design Data Resource. Calculations for all submissions (except for one, which used AutoDock4.2) wer
Autor:
Gregory D. Vite, Melissa M. Dix, Benjamin F. Cravatt, Jarrett R. Remsberg, Hsinyu Lee, Steven P. Gygi, Yujia Wang, Giulia Bianco, Christopher G. Parker, R. Michael Lawrence, Marian Kalocsay, Stefano Forli
Publikováno v:
Nature Chemistry. 11:1113-1123
A fundamental challenge in chemical biology and medicine is to understand and expand the fraction of the human proteome that can be targeted by small molecules. We recently described a strategy that integrates fragment-based ligand discovery with che
Publikováno v:
Trends Pharmacol Sci
Targeted covalent inhibitors are currently showing great promise for systems that are normally difficult to target with small molecule therapies. This renewed interest has spurred the refinement of existing computational methods as well as the design
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26638b0c2ccacad1cb69bc6a8670788d
https://europepmc.org/articles/PMC7669701/
https://europepmc.org/articles/PMC7669701/