Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Giulia, Lunghi"'
Autor:
Giulia Lunghi, Erika Di Biase, Emma Veronica Carsana, Alexandre Henriques, Noelle Callizot, Laura Mauri, Maria Grazia Ciampa, Luigi Mari, Nicoletta Loberto, Massimo Aureli, Sandro Sonnino, Michael Spedding, Elena Chiricozzi, Maria Fazzari
Publikováno v:
FEBS Open Bio, Vol 13, Iss 12, Pp 2324-2341 (2023)
Alterations in glycosphingolipid metabolism have been linked to the pathophysiological mechanisms of amyotrophic lateral sclerosis (ALS), a neurodegenerative disease affecting motor neurons. Accordingly, administration of GM1, a sialic acid‐contain
Externí odkaz:
https://doaj.org/article/bc90ee2630b94cd7baec16a20f019b9f
Autor:
Dorina Dobi, Nicoletta Loberto, Rosaria Bassi, Anna Pistocchi, Giulia Lunghi, Anna Tamanini, Massimo Aureli
Publikováno v:
FEBS Open Bio, Vol 13, Iss 9, Pp 1601-1614 (2023)
Cystic fibrosis (CF) is the most common inherited, life‐limiting disorder in Caucasian populations. It is caused by mutations in the gene encoding the cystic fibrosis transmembrane conductance regulator (CFTR), which lead to an impairment of protei
Externí odkaz:
https://doaj.org/article/cf41b81ef2a64b609a257945b0ae668e
Autor:
Andrea C. Kakouri, Christina Votsi, Anastasis Oulas, Paschalis Nicolaou, Massimo Aureli, Giulia Lunghi, Maura Samarani, Giacomo M. Compagnoni, Sabrina Salani, Alessio Di Fonzo, Thalis Christophides, George A. Tanteles, Eleni Zamba-Papanicolaou, Marios Pantzaris, George M. Spyrou, Kyproula Christodoulou
Publikováno v:
Cell & Bioscience, Vol 12, Iss 1, Pp 1-22 (2022)
Abstract Background Spastic ataxias (SAs) encompass a group of rare and severe neurodegenerative diseases, characterized by an overlap between ataxia and spastic paraplegia clinical features. They have been associated with pathogenic variants in a nu
Externí odkaz:
https://doaj.org/article/de99e0b0ac504981bfdd3b7a8d50c5f7
Publikováno v:
FEBS Open Bio, Vol 11, Iss 12, Pp 3193-3200 (2021)
Gangliosides are particularly abundant in the central nervous system, where they are mainly associated with the synaptic membranes. Their structure underlies a specific role in determining several cell physiological processes of the nervous system. T
Externí odkaz:
https://doaj.org/article/eb22c8b319e8439896d7dc9d57e2ea93
Autor:
Maria Fazzari, Giulia Lunghi, Alexandre Henriques, Noëlle Callizot, Maria Grazia Ciampa, Laura Mauri, Simona Prioni, Emma Veronica Carsana, Nicoletta Loberto, Massimo Aureli, Luigi Mari, Sandro Sonnino, Elena Chiricozzi, Erika Di Biase
Publikováno v:
Biomedicines, Vol 11, Iss 5, p 1305 (2023)
Past evidence has shown that the exogenous administration of GM1 ganglioside slowed neuronal death in preclinical models of Parkinson’s disease, a neurodegenerative disorder characterized by the progressive loss of dopamine-producing neurons: howev
Externí odkaz:
https://doaj.org/article/8a1943fc716f42f4923a8d9f878d1326
Autor:
Emma Veronica Carsana, Matteo Audano, Silvia Breviario, Silvia Pedretti, Massimo Aureli, Giulia Lunghi, Nico Mitro
Publikováno v:
Biomedicines, Vol 10, Iss 9, p 2069 (2022)
In recent years, the availability of induced pluripotent stem cell-based neuronal models has opened new perspectives on the study and therapy of neurological diseases such as Parkinson’s disease. In particular, P. Zhang set up a protocol to efficie
Externí odkaz:
https://doaj.org/article/817e3feb8c644c4a86a3f17d0da40b98
Autor:
Giulia Lunghi, Emma Veronica Carsana, Nicoletta Loberto, Laura Cioccarelli, Simona Prioni, Laura Mauri, Rosaria Bassi, Stefano Duga, Letizia Straniero, Rosanna Asselta, Giulia Soldà, Alessio Di Fonzo, Emanuele Frattini, Manuela Magni, Nara Liessi, Andrea Armirotti, Elena Ferrari, Maura Samarani, Massimo Aureli
Publikováno v:
Cells, Vol 11, Iss 15, p 2343 (2022)
β-glucocerebrosidase is a lysosomal hydrolase involved in the catabolism of the sphingolipid glucosylceramide. Biallelic loss of function mutations in this enzyme are responsible for the onset of Gaucher disease, while monoallelic β-glucocerebrosid
Externí odkaz:
https://doaj.org/article/0c02205b205142f68964b014a1490b02
Publikováno v:
Biomedicines, Vol 10, Iss 2, p 363 (2022)
Gangliosides are glycosphingolipids which are particularly abundant in the plasma membrane of mammalian neurons. The knowledge of their presence in the human brain dates back to the end of 19th century, but their structure was determined much later,
Externí odkaz:
https://doaj.org/article/214647c3fe6a49b388335d7598109068
Autor:
Giulia Lunghi, Maria Fazzari, Maria Grazia Ciampa, Laura Mauri, Erika Di Biase, Elena Chiricozzi, Sandro Sonnino
Publikováno v:
FEBS Letters. 596:3124-3132
The interactions between gangliosides and proteins belonging to the same or different lipid domains and their influence on physiological and pathological states have been analysed in detail. A well-known factor impacting on lipid-protein interactions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12198c9ad56391755f760ab1b111ac02
https://doi.org/10.1002/1873-3468.14532
https://doi.org/10.1002/1873-3468.14532
Publikováno v:
Glycoconjugate Journal. 39:27-38
GM1 is a crucial component of neuronal membrane residing both in the soma and nerve terminals. As reported in Parkinson’s disease patients, the reduction of GM1 determines the failure of fundamental functional processes leading to cumulative cell d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3645d74bb2fdc159a1657c98bbf843e
https://doi.org/10.1007/s10719-021-10019-7
https://doi.org/10.1007/s10719-021-10019-7