Atypical cofilin signaling drives dendritic cell migration through the extracellular matrix via nuclear deformation

Autor: Harry Warner, Giulia Franciosa, Guus van der Borg, Britt Coenen, Felix Faas, Claire Koenig, Rinse de Boer, René Classens, Sjors Maassen, Maksim V. Baranov, Shweta Mahajan, Deepti Dabral, Frans Bianchi, Niek van Hilten, Herre Jelger Risselada, Wouter H. Roos, Jesper Velgaard Olsen, Laia Querol Cano, Geert van den Bogaart

Publikováno v: Cell Reports, Vol 43, Iss 3, Pp 113866- (2024)

Summary: To mount an adaptive immune response, dendritic cells must migrate to lymph nodes to present antigens to T cells. Critical to 3D migration is the nucleus, which is the size-limiting barrier for migration through the extracellular matrix. Her

Externí odkaz: https://doaj.org/article/9c2fb1e58e4947c0a6fa89aaeb80c8a8

Proteomics of resistance to Notch1 inhibition in acute lymphoblastic leukemia reveals targetable kinase signatures

Autor: Giulia Franciosa, Jos G. A. Smits, Sonia Minuzzo, Ana Martinez-Val, Stefano Indraccolo, Jesper V. Olsen

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)

NOTCH1 is a driver of T-cell acute lymphoblastic leukemia that can be inhibited by γ-secretase inhibitors (GSIs), but their clinical efficacy is limited. Here, the authors compare the phosphoproteomes of GSI resistant and sensitive models, and ident

Externí odkaz: https://doaj.org/article/fb005241b37140cb8b362c5dec3d935a

Supplementary Table from Phosphorylation of SHP2 at Tyr62 Enables Acquired Resistance to SHP2 Allosteric Inhibitors in FLT3-ITD–Driven AML

Autor: Jesper V. Olsen, Lars J. Jensen, Kim Theilgaard-Mönch, Stephen C. Blacklow, Vidyasiri Vemulapalli, Kristian Reckzeh, Ilaria Piga, Marie Locard-Paulet, Giulia Franciosa, Anamarija Pfeiffer

Supplementary Table from Phosphorylation of SHP2 at Tyr62 Enables Acquired Resistance to SHP2 Allosteric Inhibitors in FLT3-ITD–Driven AML

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3670270ef0f89fb2bad014be2a715886
https://doi.org/10.1158/0008-5472.22430254.v1

Data from Phosphorylation of SHP2 at Tyr62 Enables Acquired Resistance to SHP2 Allosteric Inhibitors in FLT3-ITD–Driven AML

Autor: Jesper V. Olsen, Lars J. Jensen, Kim Theilgaard-Mönch, Stephen C. Blacklow, Vidyasiri Vemulapalli, Kristian Reckzeh, Ilaria Piga, Marie Locard-Paulet, Giulia Franciosa, Anamarija Pfeiffer

The protein tyrosine phosphatase SHP2 is crucial for oncogenic transformation of acute myeloid leukemia (AML) cells expressing mutated receptor tyrosine kinases. SHP2 is required for full RAS-ERK activation to promote cell proliferation and survival

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::78e5a2bf99c8efb8cfecfca5df859849
https://doi.org/10.1158/0008-5472.c.6513577.v1

Proteomics to study cancer immunity and improve treatment

Autor: Giulia Franciosa, Anders H. Kverneland, Agnete W. P. Jensen, Marco Donia, Jesper V. Olsen

Publikováno v: Franciosa, G, Kverneland, A H, Jensen, A W P, Donia, M & Olsen, J V 2023, ' Proteomics to study cancer immunity and improve treatment ', Seminars in Immunopathology, vol. 45, 241–251 . https://doi.org/10.1007/s00281-022-00980-2

Cancer survival and progression depend on the ability of tumor cells to avoid immune recognition. Advances in the understanding of cancer immunity and tumor immune escape mechanisms enabled the development of immunotherapeutic approaches. In patients

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de96e84827ac809cb31f98b050d8736b
https://curis.ku.dk/ws/files/355255870/s00281_022_00980_2.pdf