Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Giuditta Guerrini"'
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 11, p 5718 (2024)
The approval of safe and effective LNP-mRNA vaccines during the SARS-CoV-2 pandemic is catalyzing the development of the next generation of mRNA therapeutics. Proper characterization methods are crucial for assessing the quality and efficacy of these
Externí odkaz:
https://doaj.org/article/f2809379453e408b890b40b89b39c6be
Autor:
Giuditta Guerrini, Dora Mehn, Francesco Fumagalli, Sabrina Gioria, Mattia Pedotti, Luca Simonelli, Filippo Bianchini, Davide F. Robbiani, Luca Varani, Luigi Calzolai
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 19, p 14875 (2023)
Analytical ultracentrifugation (AUC) analysis shows that the SARS-CoV-2 trimeric Spike (S) protein adopts different quaternary conformations in solution. The relative abundance of the “open” and “close” conformations is temperature-dependent,
Externí odkaz:
https://doaj.org/article/3670807af04b42c0a8a5ab04efead400
Autor:
Vladimir Ciobanu, Francesco Roncari, Giacomo Ceccone, Tudor Braniste, Jessica Ponti, Alessia Bogni, Giuditta Guerrini, Domenico Cassano, Pascal Colpo, Ion Tiginyanu
Publikováno v:
Journal of Applied Biomaterials & Functional Materials, Vol 20 (2022)
The interaction of semiconductor nanoparticles with bio-molecules attracts increasing interest of researchers, considering the reactivity of nanoparticles and the possibility to control their properties remotely giving mechanical, thermal, or electri
Externí odkaz:
https://doaj.org/article/29809ce929ea47dd95a9384da97e1413
Autor:
Giuditta Guerrini, Sabrina Gioria, Aisha V. Sauer, Simone Lucchesi, Francesca Montagnani, Gabiria Pastore, Annalisa Ciabattini, Donata Medaglini, Luigi Calzolai
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 16, p 8838 (2022)
PEGylated lipids are one of the four constituents of lipid nanoparticle mRNA COVID-19 vaccines. Therefore, various concerns have been raised on the generation of anti-PEG antibodies and their potential role in inducing hypersensitivity reactions foll
Externí odkaz:
https://doaj.org/article/df0f9c641e144575bc452b6e0ba1cb2c
Autor:
Giuditta Guerrini, Antonio Vivi, Sabrina Gioria, Jessica Ponti, Davide Magrì, Arnd Hoeveler, Donata Medaglini, Luigi Calzolai
Publikováno v:
Vaccines, Vol 9, Iss 6, p 544 (2021)
Adjuvants have been used for decades to enhance the immune response to vaccines, in particular for the subunit-based adjuvants. Physicochemical properties of the adjuvant-protein antigen complexes, such as size, morphology, protein structure and bind
Externí odkaz:
https://doaj.org/article/7768763efee349628d3a1bf42806378c
Publikováno v:
Nature Nanotechnology. 17:570-576
Several vaccines against COVID-19 use nanoparticles to protect the antigen cargo (either proteins or nucleic acids), increase the immunogenicity and ultimately the efficacy. The characterization of these nanomedicines is challenging due to their intr
Autor:
Linda Tognetti, Camilla Marrocco, Andrea Carraro, Giuditta Guerrini, GIancarlo Mariotti, Elisa Cinotti, Pietro Rubegni
Publikováno v:
Photodermatology, Photoimmunology & Photomedicine. 38:531-540
Localized scleroderma (LS) is a rare disease leading to progressive hardening and induration of the skin and subcutaneous tissues. LS is responsive to UVA-1 phototherapy, though its exact mechanism of action dermal fibrosis is yet to be fully elucida
Autor:
Filippo Bianchini, Virginia Crivelli, Morgan E. Abernathy, Concetta Guerra, Martin Palus, Jonathan Muri, Harold Marcotte, Antonio Piralla, Mattia Pedotti, Raoul De Gasparo, Luca Simonelli, Milos Matkovic, Chiara Toscano, Maira Biggiogero, Veronica Calvaruso, Pavel Svoboda, Tomás Cervantes Rincón, Tommaso Fava, Lucie Podešvová, Akanksha A. Shanbhag, Andrea Celoria, Jacopo Sgrignani, Michal Stefanik, Vaclav Hönig, Veronika Pranclova, Tereza Michalcikova, Jan Prochazka, Giuditta Guerrini, Dora Mehn, Annalisa Ciabattini, Hassan Abolhassani, David Jarrossay, Mariagrazia Uguccioni, Donata Medaglini, Qiang Pan-Hammarström, Luigi Calzolai, Daniel Fernandez, Fausto Baldanti, Alessandra Franzetti-Pellanda, Christian Garzoni, Radislav Sedlacek, Daniel Ruzek, Luca Varani, Andrea Cavalli, Christopher O. Barnes, Davide F. Robbiani
Publikováno v:
Science Immunology
Emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants diminishes the efficacy of vaccines and antiviral monoclonal antibodies. Continued development of immunotherapies and vaccine immunogens resilient to viral evolution i
Autor:
Filippo Bianchini, Virginia Crivelli, Morgan E. Abernathy, Concetta Guerra, Martin Palus, Jonathan Muri, Harold Marcotte, Antonio Piralla, Mattia Pedotti, Raoul De Gasparo, Luca Simonelli, Milos Matkovic, Chiara Toscano, Maira Biggiogero, Veronica Calvaruso, Pavel Svoboda, Tomás Cervantes Rincón, Tommaso Fava, Lucie Podešvová, Akanksha A. Shanbhag, Andrea Celoria, Jacopo Sgrignani, Michal Stefanik, Vaclav Hönig, Veronika Pranclova, Tereza Michalcikova, Jan Prochazka, Giuditta Guerrini, Dora Mehn, Annalisa Ciabattini, Hassan Abolhassani, David Jarrossay, Mariagrazia Uguccioni, Donata Medaglini, Qiang Pan-Hammarström, Luigi Calzolai, Daniel Fernandez, Fausto Baldanti, Alessandra Franzetti-Pellanda, Christian Garzoni, Radislav Sedlacek, Daniel Ruzek, Luca Varani, Andrea Cavalli, Christopher O. Barnes, Davide F. Robbiani
Publikováno v:
bioRxiv
Emergence of SARS-CoV-2 variants diminishes the efficacy of vaccines and antiviral monoclonal antibodies. Continued development of immunotherapies and vaccine immunogens resilient to viral evolution is therefore necessary. Using coldspot-guided antib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e02f1c0f5dfbea0eb6b483dbfb44eaa
https://doi.org/10.1101/2022.11.24.515932
https://doi.org/10.1101/2022.11.24.515932
Autor:
Donata Medaglini, Giuditta Guerrini, Jessica Ponti, Arnd Hoeveler, Luigi Calzolai, Sabrina Gioria, Davide Magrì, Antonio Vivi
Publikováno v:
Vaccines
Volume 9
Issue 6
Vaccines, Vol 9, Iss 544, p 544 (2021)
Volume 9
Issue 6
Vaccines, Vol 9, Iss 544, p 544 (2021)
Adjuvants have been used for decades to enhance the immune response to vaccines, in particular for the subunit-based adjuvants. Physicochemical properties of the adjuvant-protein antigen complexes, such as size, morphology, protein structure and bind