Human NMD ensues independently of stable ribosome stalling

Autor: Evangelos D. Karousis, Lukas-Adrian Gurzeler, Giuditta Annibaldis, René Dreos, Oliver Mühlemann

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)

Nonsense-mediated mRNA decay (NMD) was thought to ensue when ribosomes fail to terminate translation properly. However, the authors observe similar ribosome occupancy at stop codons of NMD sensitive and insensitive mRNAs, showing that human NMD is no

Externí odkaz: https://doaj.org/article/e2ad888a263f4904912b1414bd2a56cf

Resurgence of Ebola Virus in 2021 in Guinea Suggests a New Paradigm for Outbreaks

Autor: Fodé B. Sako, Jacob Camara, Amadou A. Sall, Ariane Düx, Giuditta Annibaldis, Meike Pahlmann, Abdoulaye Toure, Ousmane Faye, Mamadou Condé, Haby Diallo, Steven T. Pullan, Amadou Sidibe, Moriba Povogui, Fara Raymond Koundouno, Christophe Peyrefitte, Liana E. Kafetzopoulou, Alpha Kabinet Keita, Saa L. Millimono, Mandiou Diakite, Ahmadou Doré, Karla Pietro, N'. Faly Magassouba, Fabian H. Leendertz, Nicole Vidal, Stephan Günther, Anke Thielebein, Julia Hinzmann, Dembo Diakite, Ahidjo Ayouba, Cheikh Loucoubar, Kaka Kourouma, Martin Faye, Philippe Lemey, Moussa Moïse Diagne, Mamadou D. Barry, Fodé Y. Soumah, Annick Renevey, Georges Ki-Zerbo, Kékoura Ifono, Andrew Rambaut, Abdoul K. Soumah, Miles W. Carroll, Mamadou S. Bah, Joseph Akoi Bore, Ibrahima Camara, Mamadou S. Sow, Sébastien Calvignac-Spencer, Fodé A. Traore, Sophie Duraffour, Assaïtou Bah, John T. McCrone, Nathalie J. Vielle, Joshua Quick, Noël Tordo, Moussa Baldé, Mamadou Diop, Youssouf Sidibé, Martine Peeters, Madeleine Kourouma, Sakoba Keita, Mamadou B. Keita, Frédéric Le Marcis, Cé D. Saouromou, Anais Legand, Amadou Diallo, Pierre Formenty, Almudena Mari-Saez, Michael R. Wiley, Karifa Kourouma, Eric Delaporte, Barré Soropogui

Publikováno v: Nature
Nature, 2021, Published 15 sept. 2021, ⟨10.1038/s41586-021-03901-9⟩
Nature, Nature Publishing Group, 2021, ⟨10.1038/s41586-021-03901-9⟩
Keita, A K, Koundouno, F R, Faye, M, Düx, A, Hinzmann, J, Diallo, H, Ayouba, A, Le Marcis, F, Soropogui, B, Ifono, K, Diagne, M M, Sow, M S, Bore, J A, Calvignac-Spencer, S, Vidal, N, Camara, J, Keita, M B, Renevey, A, Diallo, A, Soumah, A K, Millimono, S L, Mari-Saez, A, Diop, M, Doré, A, Soumah, F Y, Kourouma, K, Vielle, N J, Loucoubar, C, Camara, I, Kourouma, K, Annibaldis, G, Bah, A, Thielebein, A, Pahlmann, M, Pullan, S T, Carroll, M W, Quick, J, Formenty, P, Legand, A, Pietro, K, Wiley, M R, Tordo, N, Peyrefitte, C, McCrone, J T, Rambaut, A, Sidibé, Y, Barry, M D, Kourouma, M, Saouromou, C D, Condé, M, Baldé, M, Povogui, M, Keita, S, Diakite, M, Bah, M S, Sidibe, A, Diakite, D, Sako, F B, Traore, F A, Ki-Zerbo, G A, Lemey, P, Günther, S, Kafetzopoulou, L E, Sall, A A, Delaporte, E, Duraffour, S, Faye, O, Leendertz, F H, Peeters, M, Toure, A & Magassouba, N F 2021, ' Resurgence of Ebola virus in 2021 in Guinea suggests a new paradigm for outbreaks ', Nature, vol. 597, no. 7877, pp. 539-543 . https://doi.org/10.1038/s41586-021-03901-9

Seven years after the declaration of the first epidemic of Ebola virus disease in Guinea, the country faced a new outbreak—between 14 February and 19 June 2021—near the epicentre of the previous epidemic1,2. Here we use next-generation sequencing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4443684e4a88bbbab1c4d08949bf4373
https://shs.hal.science/halshs-03351513

Ribosome recycling factor ABCE1 depletion inhibits nonsense-mediated mRNA decay by promoting stop codon readthrough

Autor: Sarah H. Carl, Oliver Mühlemann, René Dreos, Michal Domanski, Giuditta Annibaldis

SUMMARYNonsense-mediated mRNA decay (NMD) is an essential post-transcriptional surveillance pathway in vertebrates that appears to be mechanistically linked with translation termination. To gain more insight into this connection, we interfered with t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d3429ffaab11867523bcf08dc0efede