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pro vyhledávání: '"Gitte Lauritzen"'
Supplementary figure 2: Inhibition of ATM and knockdown of noxa, caspase-9, μ-calpain and cathepsin B. MCF-7 vector (V) and ΔNErbB2 (ΔN) cells were washed free of tetracycline 72 h before the experiment. Cells were exposed to KU-55933 (10
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a597788977ff7bb5da257e69c7f6838
https://doi.org/10.1158/1541-7786.22511089
https://doi.org/10.1158/1541-7786.22511089
Supplementary figure 3: Working model. Pathways involved in cisplatin-induced death in MCF-7 breast cancer cells, and their relation to ΔNErbB2 expression.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29919a1bfdc67b80f4a723bd2afcb067
https://doi.org/10.1158/1541-7786.22511086
https://doi.org/10.1158/1541-7786.22511086
Supplementary figure 1: Effects of cisplatin treatment on expression of ΔNErbB2 and NHE1, and subcellular localization of cytochrome c. MCF-7 vector (V) and ΔNErbB2 (ΔN) cells were washed free of tetracycline 48 h before the experiment, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e9dc4e3558593f84469b3ac87e6fb10
https://doi.org/10.1158/1541-7786.22511092
https://doi.org/10.1158/1541-7786.22511092
Autor:
Maria Wiwel, M. B. F. Jensen, Christian-Martin Stock, Justine Lemaire, Britt Damsgaard, Albrecht Schwab, Stine F. Pedersen, Gitte Lauritzen, Katrine Seide Petersen, Lone Rønnov-Jessen, Stine Lund
Publikováno v:
Cancer Letters. 317:172-183
We and others have shown central roles of the Na(+)/H(+) exchanger NHE1 in cell motility. The aim of this study was to determine the roles of NHE1 and of the Na(+), HCO(3)(-) cotransporter NBCn1 in motility of serum-starved MCF-7 breast cancer cells
Publikováno v:
Molecular cancer research : MCR. 13(1)
Despite the frequent expression of N-terminally truncated ErbB2 (ΔNErbB2/p95HER2) in breast cancer and its association with Herceptin resistance and poor prognosis, it remains poorly understood how ΔNErbB2 affects chemotherapy-induced cell death. P
Publikováno v:
The FASEB Journal. 27
Autor:
Gitte Lauritzen, Rie Dybboe, Stine F. Pedersen, Haraldur Heidar Sigurdsson, Christina W. Olesen
Publikováno v:
The FASEB Journal. 27
Publikováno v:
The FASEB Journal. 26
Autor:
Stine F. Pedersen, Jesper Nylandsted, Rie Dybboe, Ebbe Boedtkjer, M. B. F. Jensen, Gitte Lauritzen, Christian Aalkjaer
Publikováno v:
Experimental cell research. 316(15)
Altered pH-regulatory ion transport is characteristic of many cancers; however, the mechanisms and consequences are poorly understood. Here, we investigate how a truncated, constitutively active ErbB2 receptor (DeltaNErbB2) common in breast cancer im
Autor:
Niels Krogsgaard-Larsen, Christina W. Olesen, Gitte Lauritzen, Stine F. Pedersen, Ebbe Boedtkjer, Steen Honoré Hansen, Ann M. Larsen, Lennart Bunch
Publikováno v:
Aarhus University
Larsen, A M, Krogsgaard-Larsen, N, Lauritzen, G, Olesen, C W, Hansen, S H, Boedtkjer, E, Pedersen, S F & Bunch, L 2012, ' Gram-Scale Solution-Phase Synthesis of Selective Sodium Bicarbonate Cotransport Inhibitor S0859: In Vitro Efficacy Studies in Breast Cancer Cells ', ChemMedChem, vol. 7, no. 10, pp. 1808-1814 .
Larsen, A M, Krogsgaard-Larsen, N, Lauritzen, G, Olesen, C W, Hansen, S H, Boedtkjer, E, Pedersen, S F & Bunch, L 2012, ' Gram-Scale Solution-Phase Synthesis of Selective Sodium Bicarbonate Cotransport Inhibitor S0859: In Vitro Efficacy Studies in Breast Cancer Cells ', ChemMedChem, vol. 7, no. 10, pp. 1808-1814 .
Na(+)-coupled HCO(3)(-) transporters (NBCs) mediate the transport of bicarbonate ions across cell membranes and are thus ubiquitous regulators of intracellular pH. NBC dysregulation is associated with a range of diseases; for instance, NBCn1 is stron
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c669007c3b953bf1412a4339c8049f4
https://pure.au.dk/portal/en/publications/gramscale-solutionphase-synthesis-of-selective-sodium-bicarbonate-cotransport-inhibitor-s0859-in-vitro-efficacy-studies-in-breast-cancer-cells(7d0a0ba2-8104-48eb-8130-33706c17d9e8).html
https://pure.au.dk/portal/en/publications/gramscale-solutionphase-synthesis-of-selective-sodium-bicarbonate-cotransport-inhibitor-s0859-in-vitro-efficacy-studies-in-breast-cancer-cells(7d0a0ba2-8104-48eb-8130-33706c17d9e8).html