Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Gitte Juel Friis"'
Publikováno v:
Wound Repair and Regeneration. 14:233-239
Wound pain is a serious problem for elderly patients suffering from chronic leg ulcers, and it may lead to reduced wound healing rates and reduced quality of life. Biatain-Ibu Non-adhesive (Coloplast A/S), a new pain-reducing moist wound healing dres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0edd91ae09476dce6f5258ac3b34273c
https://doi.org/10.1111/j.1743-6109.2006.00116.x
https://doi.org/10.1111/j.1743-6109.2006.00116.x
Autor:
Charlotte Adrian, Lene Just, Susan Weng, Dorrit Høj Larsen, Bernie Moss, Gitte Juel Friis, Karin Fredholt
Publikováno v:
Journal of Controlled Release. 63:261-273
The Leu-enkephalin analogue (Tyr-D-Ala-Gly-Phe-Leu-NH(2)) was synthesized together with three esters prodrugs hereof. The prodrugs synthesized were the O-acetyl, O-propionyl and O-pivaloyl99%) and in good yields (60-75%). The chemical and enzymatic s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e647025e08d3b8f6b64c402f906ad5de
https://doi.org/10.1016/s0168-3659(99)00196-0
https://doi.org/10.1016/s0168-3659(99)00196-0
Publikováno v:
European Journal of Pharmaceutical Sciences. 7:317-323
Four N-terminal 4-imidazolidinone prodrugs of Leu-enkephalin are prepared and characterized. Their enzymatic and chemical stability are assessed using high-performance liquid chromatography. The prodrug derivatives are shown to degrade stoichiometric
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94a1f87a1ad10233cb7b5eae5ab6f996
https://doi.org/10.1016/s0928-0987(98)00044-x
https://doi.org/10.1016/s0928-0987(98)00044-x
Publikováno v:
International Journal of Pharmaceutics. 178:223-229
Desmopressin [1-(mercaptopropanoic acid)-8-D-arginine vasopressin; dDAVP] is a vasopressin analogue with a selective antidiuretic effect. The oral bioavailability of desmopressin is limited due both to its high hydrophilicity leading to a low intesti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f457c02fbea72af55bfde668426c2927
https://doi.org/10.1016/s0378-5173(98)00377-9
https://doi.org/10.1016/s0378-5173(98)00377-9
Publikováno v:
Pharmaceutical Research. 16:24-29
Purpose. To evaluate the chemical and enzymatic stability, as well as the cellular permeation characteristics, of the acyloxyalkoxy-based cyclic prodrugs \(\underset{\raise0.3em\hbox{$\smash{\scriptscriptstyle-}$}}{1} \) and \(\underset{\raise0.3em\h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::78a1d649c6c2e06fcf74abfb47d1475f
https://doi.org/10.1023/a:1018854308829
https://doi.org/10.1023/a:1018854308829
Publikováno v:
International Journal of Pharmaceutics. 172:97-101
In this study, the stability in and transport across a cell culture model of the blood–brain barrier (BBB) is investigated for leucine–enkephalin (Leu–enkephalin) and four 4-imidazolidinone prodrugs of Leu–enkephalin. The results show that Le
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::36041337c65a4c6a7cd29524c28165e2
https://doi.org/10.1016/s0378-5173(98)00192-6
https://doi.org/10.1016/s0378-5173(98)00192-6
Publikováno v:
International Journal of Pharmaceutics. 154:157-165
The feasibility of achieving buccal delivery of morphine using the prodrug approach was assessed by studies of bioactivation, in vitro permeation and in vivo absorption. The bioactivation of various morphine-3-esters was studied in human plasma and s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6ab4353169338edebe730afaab670998
https://doi.org/10.1016/s0378-5173(97)00128-2
https://doi.org/10.1016/s0378-5173(97)00128-2
Publikováno v:
International Journal of Pharmaceutics. 136:61-69
Two N-Z-protected dipeptides were N-hydroxymethylated at the C-terminal peptide bond. The stability of the derivatives was investigated in aqueous buffer solutions as a function of pH. The compounds degraded quantitatively to their parent N-Z-protect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::528646aba183e7cf11fe3a5e55df1e61
https://doi.org/10.1016/0378-5173(95)04481-7
https://doi.org/10.1016/0378-5173(95)04481-7
Autor:
Gitte Juel Friis, Hans Bundgaard
Publikováno v:
European Journal of Pharmaceutical Sciences. 4:49-59
Using phenyl phoshonate and phenyl phosphate as model compounds for drugs containing these moieties a new type of α-acyloxyalkyl ester derivatives of the OH-groups are introduced. The derivatives both mask the negative charge of these compounds and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2dce8e8bb473080de735dc248e095680
https://doi.org/10.1016/0928-0987(95)00031-3
https://doi.org/10.1016/0928-0987(95)00031-3
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 3:809-812
N-Hydroxymethylation of the N-terminal peptide bond in N-acetyl-L-phenylalanine amides was found to protect the C-terminal amide bond against cleavage by α-chymotrypsin. The N-hydroxymethyl derivatives are readily bioreversible, undergoing spontaneo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cc2d0f243232d9e3fcc1122c62750ae6
https://doi.org/10.1016/s0960-894x(00)80671-x
https://doi.org/10.1016/s0960-894x(00)80671-x