Výsledky vyhledávání - "Gitte Berkers"

Akademický článek

The impact of ivacaftor on sinonasal pathology in S1251N-mediated cystic fibrosis patients.

Autor: Romee Gostelie, Inge Stegeman, Gitte Berkers, Joost Bittermann, Ivonne Ligtenberg-van der Drift, Peter-Jan van Kipshagen, Karin de Winter-de Groot, Lucienne Speleman

Publikováno v: PLoS ONE, Vol 15, Iss 7, p e0235638 (2020)

ImportanceSinonasal symptoms in patients suffering from cystic fibrosis can negatively influence the quality of life and sinuses can be a niche for pathogens causing infection and inflammation leading to a decrease of lung function. Ivacaftor, a pote

Externí odkaz: https://doaj.org/article/2594187a4dbf46f992083e3a0e93febc

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Akademický článek

Rectal Organoids Enable Personalized Treatment of Cystic Fibrosis

Publikováno v: Cell Reports, Vol 26, Iss 7, Pp 1701-1708.e3 (2019)

Summary: In vitro drug tests using patient-derived stem cell cultures offer opportunities to individually select efficacious treatments. Here, we provide a study that demonstrates that in vitro drug responses in rectal organoids from individual patie

Externí odkaz: https://doaj.org/article/dc8d3a11cbb948418c73a2e8f5b11051

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Breast development in a 7 year old girl with CF treated with ivacaftor: An indication for personalized dosing?

Autor: Harry G.M. Heijerman, Renske van der Meer, Jeffrey M. Beekman, Gitte Berkers, Cornelis K. van der Ent, Joshena Jeyaratnam

Publikováno v: Journal of Cystic Fibrosis. 20:e63-e66

Substantial progress has been made in the treatment of Cystic fibrosis due to introduction of CFTR modulators. However, little is known about the long term side effects of treatment with these drugs. We here present a 7 year old girl with CF who pres

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c77acc1feca60a43625a4b9228e2bac9
https://doi.org/10.1016/j.jcf.2021.06.001

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Lumacaftor/ivacaftor in people with cystic fibrosis with an A455E–CFTR mutation

Autor: C. Kors van der Ent, Renske van der Meer, Sylvia F. Boj, Robert G.J. Vries, Harry G.M. Heijerman, Peter van Mourik, Paul K. Audhya, Jamie R Doyle, Jeffrey M. Beekman, Zheng Jason Yuan, N. Kinnman, Gitte Berkers

Publikováno v: Journal of Cystic Fibrosis. 20:761-767

Background Previous in vitro organoid data showed A455E–CFTR, a rare CFTR mutation with 4.1% prevalence in the Netherlands, responds to lumacaftor/ivacaftor (LUM/IVA). We explored LUM/IVA's clinical efficacy in people with CF and ≥1 A455E–CFTR

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39e7cd4bc1b9aa6bdfa4cf0c9c20123f
https://doi.org/10.1016/j.jcf.2020.11.007

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Forskolin-induced swelling of intestinal organoids correlates with disease severity in adults with cystic fibrosis and homozygous F508del mutations

Autor: Sjoerd G. Elias, Gitte Berkers, Harry G.M. Heijerman, Rozemarijn E.P. Marck – van der Wilt, Renske van der Meer, Margot Geerdink, E. Kruisselbrink, S. Michel, Cornelis K. van der Ent, Jeffrey M. Beekman, Hans Clevers, Karin de Winter-de Groot, Rob Vries, Johanna F. Dekkers, Frank P. Vleggaar, Annelotte M. Vonk

Publikováno v: Journal of Cystic Fibrosis. Elsevier B.V.

Background CFTR function measurements in intestinal organoids may help to better characterise individual disease expression in F508del homozygous people. Our objective was to study correlations between CFTR function as measured with forskolin-induced

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75f95b46e1ca9cbf12935229cbcfd59a
https://doi.org/10.1016/j.jcf.2019.10.022

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Long‐term effects of ivacaftor on nonpulmonary outcomes in individuals with cystic fibrosis, heterozygous for a S1251N mutation

Autor: Hj Erik Hulzebos, Hgm Harry Heijerman, Tim Takken, Fm Francis Hollander-Kraaijeveld, Ck Kors van der Ent, M. Burghard, S Sophie Ghijsen, Gitte Berkers, Km Karin de Winter-de Groot

Publikováno v: Pediatric Pulmonology

Objectives To describe the long-term effects of ivacaftor (Kalydeco®) in individuals with cystic fibrosis (CF) on body mass index (BMI), body composition (BC), pulmonary function (PF), resting energy expenditure (REE), and exercise capacity (EC) aft

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eabc236942aa694fdb9ee0430dcee979
https://doi.org/10.1002/ppul.24745

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Individual and Group Response of Treatment with Ivacaftor on Airway and Gut Microbiota in People with CF and a S1251N Mutation

Autor: Renske van der Meer, Harry G.M. Heijerman, Hubertus G.M. Arets, Gitte Berkers, Karin M. de Winter-de Groot, Mei Ling J N Chu, Hettie M. Janssens, Kayleigh Arp, Christof J. Majoor, Debby Bogaert, S Sophie Ghijsen, Cornelis K. van der Ent, Maartje I Kristensen

Publikováno v: Journal of Personalized Medicine
Journal of Personalized Medicine, Vol 11, Iss 350, p 350 (2021)
Volume 11
Issue 5
Journal of Personalized Medicine, 11(5):350. Multidisciplinary Digital Publishing Institute (MDPI)

Ivacaftor has been shown to restore the functionality of the S1251N (also known as c.3752G>
A) mutated CFTR, which may cause alterations in both airway and gut physiology and micro-environment, resulting in a change of microbiota in these orga

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::555a169e32259d36e05bdbe59e12885d
http://europepmc.org/articles/PMC8146888

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Forskolin-induced organoid swelling is associated with long-term cystic fibrosis disease progression

Publikováno v: European Respiratory Journal, 60
European Respiratory Journal, 60, 2
European Respiratory Journal, 60(2):2100508. European Respiratory Society
European respiratory journal, 60(2):2100508. European Respiratory Society
Muilwijk, D, de Poel, E, van Mourik, P, Suen, S W F, Vonk, A M, Brunsveld, J E, Kruisselbrink, E, Oppelaar, H, Hagemeijer, M C, Berkers, G, de Winter-de Groot, K M, Heida-Michel, S, Jans, S R, van Panhuis, H, van der Eerden, M M, van der Meer, R, Roukema, J, Dompeling, E, Weersink, E J M, Koppelman, G H, Vries, R, Zomer-van Ommen, D D, Eijkemans, M J C, van der Ent, C K & Beekman, J M 2022, ' Forskolin-induced organoid swelling is associated with long-term cystic fibrosis disease progression ', European Respiratory Journal, vol. 60, no. 2, 2100508 . https://doi.org/10.1183/13993003.00508-2021

RationaleCystic fibrosis (CF) is a monogenic life-shortening disease associated with highly variable individual disease progression which is difficult to predict. Here we assessed the association of forskolin-induced swelling (FIS) of patient-derived

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cf9da16f7bb9568249c8cf57a8787cc
https://pubmed.ncbi.nlm.nih.gov/35086832

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