Improving Target and Suspect Screening High-Resolution Mass Spectrometry Workflows in Environmental Analysis by Ion Mobility Separation

Autor: Jeff Goshawk, Juan V. Sancho, Alberto Celma, Emma L. Schymanski, Lubertus Bijlsma, Félix Hernández, Gitte Barknowitz, María Ibáñez, David Fabregat-Safont

Publikováno v: Repositori Universitat Jaume I
Universitat Jaume I

Currently, the most powerful approach to monitor organic micropollutants (OMPs) in environmental samples is the combination of target, suspect, and nontarget screening strategies using high-resolution mass spectrometry (HRMS). However, the high compl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c4502400ec25f121242fec124b66baf
https://pubmed.ncbi.nlm.nih.gov/33207875

Interlaboratory and Interplatform Study of Steroids Collision Cross Section by Traveling Wave Ion Mobility Spectrometry

Autor: Evelyne Vigneau, Bruno Le Bizec, Serge Rudaz, Davy Guillarme, David Ropartz, Maykel Hernández-Mesa, Mathieu Fanuel, Hélène Rogniaux, Nicola Dreolin, Fabrice Monteau, Julian Pezzatti, Valentina D'Atri, Sara Stead, Gaud Dervilly, Gitte Barknowitz

Publikováno v: Analytical Chemistry
Analytical Chemistry, American Chemical Society, 2020, 92 (7), pp.5013-5022. ⟨10.1021/acs.analchem.9b05247⟩
Analytical Chemistry, Vol. 92, No 7 (2020) pp. 5013-5022

International audience; Collision cross section (CCS) databases based on single-laboratory measurements must be cross-validated to extend their use in peak annotation. This work addresses the validation of the first comprehensive TWCCSN2 database for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bbff5fb4d8e91bec6f2e3895d6548df
https://hal.inrae.fr/hal-03191081

1-Methoxy-3-indolylmethyl DNA adducts in six tissues, and blood protein adducts, in mice under pak choi diet: time course and persistence

Autor: Melanie, Wiesner-Reinhold, Gitte, Barknowitz, Simone, Florian, Inga, Mewis, Fabian, Schumacher, Monika, Schreiner, Hansruedi, Glatt

Publikováno v: Archives of toxicology. 93(6)

We previously showed that purified 1-methoxy-3-indolylmethyl (1-MIM) glucosinolate, a secondary plant metabolite in Brassica species, is mutagenic in various in vitro systems and forms DNA and protein adducts in mouse models. In the present study, we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::05c95b09f17b0eb2faf96ebe596c5d4f
https://pubmed.ncbi.nlm.nih.gov/30993378

Identification and Quantification of Protein Adducts Formed by Metabolites of 1-Methoxy-3-indolylmethyl Glucosinolate in Vitro and in Mouse Models

Autor: Stephan Schmidt, Mareike Bernau, Simone Florian, Wolfram Engst, Bernhard H. Monien, Hansruedi Glatt, Markus Kramer, Gitte Barknowitz

Publikováno v: Chemical Research in Toxicology. 27:188-199

1-Methoxy-3-indolylmethyl (1-MIM) glucosinolate (GLS) occurring in cabbage, broccoli, and other cruciferous plants is a potent mutagen requiring metabolic activation by myrosinase present in plant cells and intestinal bacteria. We previously reported

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71b7531109ae233f49be1cbcb7828de9
https://doi.org/10.1021/tx400277w

Mutagenicity of 5-hydroxymethylfurfural in V79 cells expressing human SULT1A1: identification and mass spectrometric quantification of DNA adducts formed

Autor: Wolfram Engst, Albrecht Seidel, Gitte Barknowitz, Bernhard H. Monien, Hansruedi Glatt

Publikováno v: Chemical research in toxicology. 25(7)

5-Hydroxymethylfurfural (HMF), a heterocyclic product of the Maillard reaction, is a ubiquitous food contaminant. It has demonstrated hepatocarcinogenic activity in female mice. This effect may originate from sulfo conjugation of the benzylic alcohol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e38def1b34b48730e7a2df3623d4b5e1
https://pubmed.ncbi.nlm.nih.gov/22563731