Výsledky vyhledávání - "Gitta Maria Seleznik"

Serotonin uptake is required for Rac1 activation in Kras-induced acinar-to-ductal metaplasia in the pancreas

Autor: Gitta Maria Seleznik, Rossella Parrotta, Sabrina Sonda, Paola Martinelli, Amedeo Caflisch, Francesco Baschieri, Rolf Graf, Irene Esposito, Michele Visentin, Marta Bombardo, Ermanno Malagola, Johanna Buschmann, Hesso Farhan, Rong Chen, Nathalie Borgeaud, Enrica Saponara

Publikováno v: The Journal of Pathology. 246:352-365

Pancreatic ductal adenocarcinoma (PDAC), the primary cause of pancreatic cancer mortality, is poorly responsive to currently available interventions. Identifying new targets that drive PDAC formation and progression is critical to develop alternative

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e17b0940939d0363e46511478fac94f6
https://doi.org/10.1002/path.5147

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Class I histone deacetylase inhibition improves pancreatitis outcome by limiting leukocyte recruitment and acinar-to-ductal metaplasia

Autor: Enrica Saponara, Theresia Reding, Evans Quilichini, Anja Zabel, Rong Chen, Cécile Haumaitre, Gitta Maria Seleznik, Marta Bombardo, Ermanno Malagola, Rolf Graf, Sabrina Sonda

Publikováno v: British Journal of Pharmacology. 174:3865-3880

Background and Purpose Pancreatitis is a common inflammation of the pancreas with rising incidence in many countries. Despite improvements in diagnostic techniques, the disease is associated with high risk of severe morbidity and mortality and there

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0c77c22bc756960e1ded6cd72ecefabd
https://doi.org/10.1111/bph.13984

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Enhanced proliferation of pancreatic acinar cells in MRL/MpJ mice is driven by severe acinar injury but independent of inflammation

Autor: Rong Chen, Sabrina Sonda, Ermanno Malagola, Rolf Graf, Gitta Maria Seleznik, Marta Bombardo, Andrew P. Hills, Arcangelo F. Carta

Publikováno v: Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
Scientific Reports

Adult pancreatic acinar cells have the ability to re-enter the cell cycle and proliferate upon injury or tissue loss. Despite this mitotic ability, the extent of acinar proliferation is often limited and unable to completely regenerate the injured ti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a81e2188f9789bf2febe38b52b8ea99a
https://doi.org/10.5167/uzh-166051

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Inactivation of TGFβ receptor II signalling in pancreatic epithelial cells promotes acinar cell proliferation, acinar-to-ductal metaplasia and fibrosis during pancreatitis

Autor: Anja Zabel, Rolf Graf, Marta Bombardo, Enrica Saponara, Kamile Grabliauskaite, Theresia Reding, Carmen Faso, Gitta Maria Seleznik, Ermanno Malagola, Sabrina Sonda

Publikováno v: The Journal of Pathology. 238:434-445

Determining signalling pathways that regulate pancreatic regeneration following pancreatitis is critical for implementing therapeutic interventions. In this study we elucidated the molecular mechanisms underlying the effects of transforming growth fa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::112d72c24aedb06869f33bd7e09ba42c
https://doi.org/10.1002/path.4666

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Serotonin promotes acinar dedifferentiation following pancreatitis-induced regeneration in the adult pancreas

Autor: Adrian B. Hehl, Kamile Grabliauskaite, Theresia Reding, Rolf Graf, Enrica Saponara, Yinghua Tian, Alberto B. Silva, Elisabeth M. Schraner, Sabrina Sonda, Ermanno Malagola, Gitta Maria Seleznik, Raphael M Buzzi, Marta Bombardo, Anja Zabel

Publikováno v: The Journal of Pathology. 237:495-507

The exocrine pancreas exhibits a distinctive capacity for tissue regeneration and renewal following injury. This regenerative ability has important implications for a variety of disorders, including pancreatitis and pancreatic cancer, diseases associ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::952e26b9f9b0372e0228248534723678
https://doi.org/10.1002/path.4595

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NIK promotes tissue destruction independently of the alternative NF-κB pathway through TNFR1/RIP1-induced apoptosis

Publikováno v: Cell Death Differ. 22, 2020-2033 (2015)
Cell death and differentiation

NF-κB-inducing kinase (NIK) is well-known for its role in promoting p100/NF-κB2 processing into p52, a process defined as the alternative, or non-canonical, NF-κB pathway. Here we reveal an unexpected new role of NIK in TNFR1-mediated RIP1-depende

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8eca7c065b0fc4d9e0112acaf23025a
https://doi.org/10.1038/cdd.2015.69

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p21(WAF1/Cip1) limits senescence and acinar-to-ductal metaplasia formation during pancreatitis

Autor: Rolf Graf, Richard A. Zuellig, Kamile Grabliauskaite, Theresia Reding, Martha Bain, Kathryn Schlesinger, Anja Dittmann, Sabrina Sonda, Gitta Maria Seleznik, Enrica Saponara, Adrian B. Hehl

Publikováno v: JOURNAL OF PATHOLOGY

Trans-differentiation of pancreatic acinar cells into ductal-like lesions, a process defined as acinar-to-ductal metaplasia (ADM), is observed in the course of organ regeneration following pancreatitis. In addition, ADM is found in association with p

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The pancreas responds to remote damage and systemic stress by secretion of the pancreatic secretory proteins PSP/regI and PAP/regIII

Autor: Leandro Mancina, Clinsyjos Pazhepurackel, Ursula Süss, Sabrina Steiner, Marc Schiesser, Cristian Palmiere, Gitta Maria Seleznik, Andrea Schlegel, Rolf Graf, Daniel Bimmler, Theresia Reding

Publikováno v: Oncotarget
Oncotarget, vol. 8, no. 18, pp. 30162-30174

// Theresia Reding 1, * , Cristian Palmiere 2, * , Clinsyjos Pazhepurackel 1 , Marc Schiesser 1 , Daniel Bimmler 1 , Andrea Schlegel 1 , Ursula Suss 1 , Sabrina Steiner 1 , Leandro Mancina 1 , Gitta Seleznik 1 , Rolf Graf 1 1 Department of Visceral a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39b2f3a34866521242419f0fe7f5b909
https://www.zora.uzh.ch/id/eprint/139105/

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Nonredundant Function of Soluble LTα 3 Produced by Innate Lymphoid Cells in Intestinal Homeostasis

Autor: Dan R. Littman, Alexei V. Tumanov, Gitta Maria Seleznik, Caroline Winsauer, Sergei A. Nedospasov, Sergei I. Grivennikov, Sandra Prepens, Dmitry V. Kuprash, Mathias Heikenwalder, Andrey Kruglov, Gérard Eberl

Publikováno v: Science. 342:1243-1246

Command and Control Innate lymphoid cells are vital for the development of gut-associated lymphoid tissues, maintenance of the epithelial barrier, and protection against intestinal microbes; their dysfunction can promote immune pathology. Immunoglobu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f165cef1f5d532d66e4663de29e13d33
https://doi.org/10.1126/science.1243364

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