Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Gitta K. Kuipers"'
Autor:
Irene V. Bijnsdorp, Johannes van Rijn, Ben J. Slotman, Jaap van den Berg, Gitta K. Kuipers, Laurine E. Wedekind, M. Vincent M. Lafleur, Peter Sminia
Publikováno v:
Bijnsdorp, I, van den Berg, J, Kuipers, G, Wedekind, L, Slotman, B, van Rijn, J, Lafleur, M & Sminia, P 2007, ' Radiosensitizing potential of the selective cyclooygenase-2 (COX-2) inhibitor meloxicam on human glioma cells ', Journal of Neuro-Oncology, vol. 85, no. 1, pp. 25-31 .
Journal of Neuro-Oncology, 85(1), 25-31. Kluwer Academic Publishers
Bijnsdorp, I, Kuipers, G, Lafleur, M, Slotman, B, Sminia, P, van de Berg, J, van Rijn, J & Wedekind, L 2007, ' Radiosensitizing potential of the selective cyclooygenase-2 (COX-2) inhibitor meloxicam on human glioma cells ', Journal of Neuro-Oncology, vol. 85, no. 1, pp. 25-31 .
Bijnsdorp, I V, van den Berg, J, Kuipers, G K, Wedekind, L E, Slotman, B J, van Rijn, J, Lafleur, M V M & Sminia, P 2007, ' Radiosensitizing potential of the selective cyclooygenase-2 (COX-2) inhibitor meloxicam on human glioma cells ', Journal of Neuro-Oncology, vol. 85, no. 1, pp. 25-31 . https://doi.org/10.1007/s11060-007-9385-4
Journal of Neuro-Oncology, 85(1), 25-31. Kluwer Academic Publishers
Bijnsdorp, I, Kuipers, G, Lafleur, M, Slotman, B, Sminia, P, van de Berg, J, van Rijn, J & Wedekind, L 2007, ' Radiosensitizing potential of the selective cyclooygenase-2 (COX-2) inhibitor meloxicam on human glioma cells ', Journal of Neuro-Oncology, vol. 85, no. 1, pp. 25-31 .
Bijnsdorp, I V, van den Berg, J, Kuipers, G K, Wedekind, L E, Slotman, B J, van Rijn, J, Lafleur, M V M & Sminia, P 2007, ' Radiosensitizing potential of the selective cyclooygenase-2 (COX-2) inhibitor meloxicam on human glioma cells ', Journal of Neuro-Oncology, vol. 85, no. 1, pp. 25-31 . https://doi.org/10.1007/s11060-007-9385-4
The COX-2 protein is frequently overexpressed in human malignant gliomas. This expression has been associated with their aggressive growth characteristics and poor prognosis for patients. Targeting the COX-2 pathway might improve glioma therapy. In t
Autor:
T. Rianne Stoter, M. Vincent M. Lafleur, Frank J. P. Hoebers, Ben J. Slotman, Michiel W. M. van den Brekel, R. Dubbelman, Marcel Verheij, Gitta K. Kuipers, Shuraila F. Zerp
Publikováno v:
Zerp, S F, Stoter, R, Hoebers, F J P, van den Brekel, M W M, Dubbelman, R, Kuipers, G K, Lafleur, M V M, Slotman, B J & Verheij, M 2015, ' Targeting anti-apoptotic Bcl-2 by AT-101 to increase radiation efficacy: data from in vitro and clinical pharmacokinetic studies in head and neck cancer ', Radiation Oncology, vol. 10, 158 . https://doi.org/10.1186/s13014-015-0474-9
Radiation Oncology, 10:158. BioMed Central Ltd
Radiation Oncology, 10:158. BioMed Central
Radiation Oncology (London, England)
Radiation Oncology, 10:158. BioMed Central Ltd
Radiation Oncology, 10:158. BioMed Central
Radiation Oncology (London, England)
BackgroundPro-survival Bcl-2 family members can promote cancer development and contribute to treatment resistance. Head and neck squamous cell carcinoma (HNSCC) is frequently characterized by overexpression of anti-apoptotic Bcl-2 family members. Inc
Autor:
Peter Sminia, Paul van der Valk, W. Peter Vandertop, Thea M. Tadema, Paula H.M. Elkhuizen, M. Vincent M. Lafleur, Ben J. Slotman, T. Rianne Stoter, Gitta K. Kuipers
Publikováno v:
Journal of Cancer Research and Clinical Oncology, 131(10), 653-61. Springer Verlag
Journal of cancer research and clinical oncology, 131(10), 653-661. Springer Verlag
Sminia, P, Stoter, T R, van der Valk, P, Elkhuizen, P H M, Tadema, T M, Kuipers, G K, Vandertop, W P, Lafleur, M V M & Slotman, B J 2005, ' Expression of cyclooxygenase-2 and epidermal growth factor receptor in primary and recurrent glioblastoma multiforme ', Journal of Cancer Research and Clinical Oncology, vol. 131, no. 10, pp. 653-61 . https://doi.org/10.1007/s00432-005-0020-5
Journal of cancer research and clinical oncology, 131(10), 653-661. Springer Verlag
Sminia, P, Stoter, T R, van der Valk, P, Elkhuizen, P H M, Tadema, T M, Kuipers, G K, Vandertop, W P, Lafleur, M V M & Slotman, B J 2005, ' Expression of cyclooxygenase-2 and epidermal growth factor receptor in primary and recurrent glioblastoma multiforme ', Journal of Cancer Research and Clinical Oncology, vol. 131, no. 10, pp. 653-61 . https://doi.org/10.1007/s00432-005-0020-5
PURPOSE: To investigate the pattern and level of cyclooxygenase-2 (COX-2) expression in a series of high grade primary and recurrent glioblastoma multiforme (GBM) and correlation with time to recurrence and patients' survival following therapy. The r
Autor:
Rob J. van Andel, Gitta K. Kuipers, M. Vincent M. Lafleur, Carola A. Reitsma-Wijker, Ben J. Slotman, Hester A. Poldervaart
Publikováno v:
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 568(2), 171-7. Elsevier
Kuipers, G K, Slotman, B J, Reitsma-Wijker, CA, Andel, R J, Poldervaart, H A & Lafleur, M V M 2004, ' Influence of anoxia on the induction of mutations by phenylalanine radicals during gamma-irradiation of plasmid DNA in aqueous solution. ', Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, vol. 568, no. 2, pp. 171-7 . https://doi.org/10.1016/j.mrfmmm.2004.08.005
Kuipers, G K, Slotman, B J, Reitsma-Wijker, CA, Andel, R J, Poldervaart, H A & Lafleur, M V M 2004, ' Influence of anoxia on the induction of mutations by phenylalanine radicals during gamma-irradiation of plasmid DNA in aqueous solution. ', Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, vol. 568, no. 2, pp. 171-7 . https://doi.org/10.1016/j.mrfmmm.2004.08.005
When DNA is irradiated in aqueous solution, most of the damage is inflicted by water-derived radicals. This is called the indirect effect of ionizing radiation. However in whole cells not only the primary formed water radicals play a role, because so
Publikováno v:
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 479:95-99
Because damage to the cellular DNA is very hazardous for a cell, it is important to identify compounds, which can cause DNA damage. To investigate the mutagenic effect of a particular agent of interest, usually mutation spectra are determined in a se
Autor:
Gitta K. Kuipers, Hester A Poldervaart, M. Vincent M. Lafleur, Ben J. Slotman, Carola A Reitsma-Wijker
Publikováno v:
Mutation Research/DNA Repair. 461:189-195
One of the most predominating oxidative DNA damages, both spontaneously formed and after gamma-radiation is 7, 8-dihydro-8-oxoguanine (8oxoG). This 8oxoG is a mutagenic lesion because it can mispair with adenine instead of the correct cytosine leadin
Autor:
Gitta K. Kuipers, Hester A Poldervaart, Ben J. Slotman, Carola A Reitsma-Wijker, Ingrid M.J van Vilsteren, M. Vincent M. Lafleur
Publikováno v:
Mutation Research/DNA Repair. 460:117-125
Base excision repair (BER) is a very important repair mechanism to remove oxidative DNA damage. A major oxidative DNA damage after exposure to ionizing radiation is 7,8-dihydro-8-oxoguanine (8oxoG). 8oxoG is a strong mutagenic lesion, which may cause
Autor:
Jacqueline Cloos, Gitta K. Kuipers, Laurine E. Wedekind, Dannis G. van Vuurden, ertop, Esther Hulleman, W Peter, Gertjan J.L. Kaspers, David P. Noske, Shruti Shukla, Ben J. Slotman, M. Vincent M. Lafleur
Publikováno v:
Journal of cancer science and therapy, 5(7), 249-255. OMICS Publishing Group
Journal of Cancer Science & Therapy, 249-255. OMICS Publishing Group
ISSUE=5;STARTPAGE=249;ENDPAGE=255;ISSN=1948-5956;TITLE=Journal of Cancer Science & Therapy
van Vuurden, D G, Shukla, S, Kuipers, G K, Noske, D P, Vandertop, W P, Lafleur, M V M, Slotman, B J, Hulleman, E, Kaspers, G J L & Cloos, J 2013, ' Cytotoxicity and Radiosensitization of High Grade Glioma Cells by CI-1033, an Irreversible Pan-ErbB Inhibitor ', Journal of Cancer Science & Therapy, no. 5, pp. 249-255 . https://doi.org/10.4172/1948-5956.1000213
Journal of Cancer Science & Therapy, 249-255. OMICS Publishing Group
ISSUE=5;STARTPAGE=249;ENDPAGE=255;ISSN=1948-5956;TITLE=Journal of Cancer Science & Therapy
van Vuurden, D G, Shukla, S, Kuipers, G K, Noske, D P, Vandertop, W P, Lafleur, M V M, Slotman, B J, Hulleman, E, Kaspers, G J L & Cloos, J 2013, ' Cytotoxicity and Radiosensitization of High Grade Glioma Cells by CI-1033, an Irreversible Pan-ErbB Inhibitor ', Journal of Cancer Science & Therapy, no. 5, pp. 249-255 . https://doi.org/10.4172/1948-5956.1000213
Background: High-grade gliomas (HGG) are highly infiltrative malignancies, causing considerable mortality in child- and adulthood, necessitating new therapies. Novel therapies directed against multiple epidermal growth factor family (ErbB) members ar
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https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd522ad2186c2fe2cab4f21cb5b79bdf
https://pure.amc.nl/en/publications/cytotoxicity-and-radiosensitization-of-high-grade-glioma-cells-by-ci1033-an-irreversible-panerbb-inhibitor(d1e1d8f3-7d9c-491c-b937-82f2b7818c27).html
https://pure.amc.nl/en/publications/cytotoxicity-and-radiosensitization-of-high-grade-glioma-cells-by-ci1033-an-irreversible-panerbb-inhibitor(d1e1d8f3-7d9c-491c-b937-82f2b7818c27).html
Autor:
Rianne Stoter, Gitta K. Kuipers, M. Verheij, Marc E. Lippman, Shuraila F. Zerp, Wim J. van Blitterswijk, Dajun Yang, Harry Bartelink, Vincent Lafleur, Rogier W. Rooswinkel
Publikováno v:
Radiation Oncology, Vol 4, Iss 1, p 47 (2009)
Radiation Oncology, 4:47. BioMed Central
Zerp, S F, Stoter, T R, Kuipers, G K, Yang, D, Lippman, L E, van Blitterswijk, W J, Bartelink, H, Rooswinkel, R, Lafleur, M V M & Verheij, M 2009, ' AT-101, a small molecule inhibitor of anti-apoptotic Bcl-2 family members, activates the SAPK/JNK pathway and enhances radiation-induced apoptosis ', Radiation Oncology, vol. 4, 47 . https://doi.org/10.1186/1748-717X-4-47
Radiation Oncology (London, England)
Radiation Oncology, 4:47. BioMed Central
Zerp, S F, Stoter, T R, Kuipers, G K, Yang, D, Lippman, L E, van Blitterswijk, W J, Bartelink, H, Rooswinkel, R, Lafleur, M V M & Verheij, M 2009, ' AT-101, a small molecule inhibitor of anti-apoptotic Bcl-2 family members, activates the SAPK/JNK pathway and enhances radiation-induced apoptosis ', Radiation Oncology, vol. 4, 47 . https://doi.org/10.1186/1748-717X-4-47
Radiation Oncology (London, England)
BackgroundGossypol, a naturally occurring polyphenolic compound has been identified as a small molecule inhibitor of anti-apoptotic Bcl-2 family proteins. It induces apoptosis in a wide range of tumor cell lines and enhances chemotherapy- and radiati
Autor:
T. Rianne Stoter, Gitta K. Kuipers, Peter Sminia, M. Vincent M. Lafleur, Laurine E. Wedekind, Ben J. Slotman, Jaap van den Berg
Publikováno v:
International Journal of Radiation Biology, 83(10), 677-85. Informa Healthcare
Kuipers, G K, Slotman, B J, Wedekind, L E, Stoter, T R, Berg, J V D, Sminia, P & Lafleur, M V M 2007, ' Radiosensitization of human glioma cells by cyclooxygenase-2 (COX-2) inhibition : independent on COX-2 expression and dependent on the COX-2 inhibitor and sequence of administration ', International Journal of Radiation Biology, vol. 83, no. 10, pp. 677-85 . https://doi.org/10.1080/09553000701558985
Kuipers, G K, Slotman, B J, Wedekind, L E, Stoter, T R, Berg, J V D, Sminia, P & Lafleur, M V M 2007, ' Radiosensitization of human glioma cells by cyclooxygenase-2 (COX-2) inhibition : independent on COX-2 expression and dependent on the COX-2 inhibitor and sequence of administration ', International Journal of Radiation Biology, vol. 83, no. 10, pp. 677-85 . https://doi.org/10.1080/09553000701558985
PURPOSE: Patients with a malignant glioma have a very poor prognosis. Cyclooxygenase-2 (COX-2) protein is regularly upregulated in gliomas and might be a potential therapeutic target. The effects of three selective COX-2 inhibitors were studied on th