Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Gitta Anne, Heinz"'
Autor:
Patrick J. Dörner, Harithaa Anandakumar, Ivo Röwekamp, Facundo Fiocca Vernengo, Belén Millet Pascual-Leone, Marta Krzanowski, Josua Sellmaier, Ulrike Brüning, Raphaela Fritsche-Guenther, Lennart Pfannkuch, Florian Kurth, Miha Milek, Vanessa Igbokwe, Ulrike Löber, Birgitt Gutbier, Markus Holstein, Gitta Anne Heinz, Mir-Farzin Mashreghi, Leon N. Schulte, Ann-Brit Klatt, Sandra Caesar, Sandra-Maria Wienhold, Stefan Offermanns, Matthias Mack, Martin Witzenrath, Stefan Jordan, Dieter Beule, Jennifer A. Kirwan, Sofia K. Forslund, Nicola Wilck, Hendrik Bartolomaeus, Markus M. Heimesaat, Bastian Opitz
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Hospital-acquired pneumonia (HAP) is associated with high mortality and costs, and frequently caused by multidrug-resistant (MDR) bacteria. Although prior antimicrobial therapy is a major risk factor for HAP, the underlying mechanism remains
Externí odkaz:
https://doaj.org/article/41a8a643c26b41c0b66352c312b98b9b
Autor:
Peter K Jani, Georg Petkau, Yohei Kawano, Uwe Klemm, Gabriela Maria Guerra, Gitta Anne Heinz, Frederik Heinrich, Pawel Durek, Mir-Farzin Mashreghi, Fritz Melchers
Publikováno v:
PLoS Biology, Vol 21, Iss 11, p e3002015 (2023)
Throughout life, hematopoietic stem cells (HSCs), residing in bone marrow (BM), continuously regenerate erythroid/megakaryocytic, myeloid, and lymphoid cell lineages. This steady-state hematopoiesis from HSC and multipotent progenitors (MPPs) in BM c
Externí odkaz:
https://doaj.org/article/f5721978d1074d5487f1c9dc30066fbd
Autor:
Christopher M. Skopnik, René Riedel, Richard K. Addo, Gitta Anne Heinz, Frederik Heinrich, Kazuhito Honjo, Pawel Durek, Philipp Enghard, Mir-Farzin Mashreghi, Andreas Radbruch, Hiromi Kubagawa
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-4 (2022)
Externí odkaz:
https://doaj.org/article/80337a67e08f4afe87d3f3623dc97933
Autor:
Marta Ferreira-Gomes, Andrey Kruglov, Pawel Durek, Frederik Heinrich, Caroline Tizian, Gitta Anne Heinz, Anna Pascual-Reguant, Weijie Du, Ronja Mothes, Chaofan Fan, Stefan Frischbutter, Katharina Habenicht, Lisa Budzinski, Justus Ninnemann, Peter K. Jani, Gabriela Maria Guerra, Katrin Lehmann, Mareen Matz, Lennard Ostendorf, Lukas Heiberger, Hyun-Dong Chang, Sandy Bauherr, Marcus Maurer, Günther Schönrich, Martin Raftery, Tilmann Kallinich, Marcus Alexander Mall, Stefan Angermair, Sascha Treskatsch, Thomas Dörner, Victor Max Corman, Andreas Diefenbach, Hans-Dieter Volk, Sefer Elezkurtaj, Thomas H. Winkler, Jun Dong, Anja Erika Hauser, Helena Radbruch, Mario Witkowski, Fritz Melchers, Andreas Radbruch, Mir-Farzin Mashreghi
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Our understanding on the humoral immunity induced by SARS-CoV-2 is still lacking. Here the authors analyze B cell responses at the single cell level to find that, in severe COVID-19 patients, plasmablasts shift from IFN to TGFβ instruction to produc
Externí odkaz:
https://doaj.org/article/58a67a60b8ae4622829438abe4d63e7c
Autor:
René Riedel, Richard Addo, Marta Ferreira-Gomes, Gitta Anne Heinz, Frederik Heinrich, Jannis Kummer, Victor Greiff, Daniel Schulz, Cora Klaeden, Rebecca Cornelis, Ulrike Menzel, Stefan Kröger, Ulrik Stervbo, Ralf Köhler, Claudia Haftmann, Silvia Kühnel, Katrin Lehmann, Patrick Maschmeyer, Mairi McGrath, Sandra Naundorf, Stefanie Hahne, Özen Sercan-Alp, Francesco Siracusa, Jonathan Stefanowski, Melanie Weber, Kerstin Westendorf, Jakob Zimmermann, Anja E. Hauser, Sai T. Reddy, Pawel Durek, Hyun-Dong Chang, Mir-Farzin Mashreghi, Andreas Radbruch
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Memory B cells are important for protecting the host from pathogen rechallenge, but their properties and locations remain ill-defined. Here the authors show, using single-cell transcriptomics and repertoire analyses, that mouse spleen and bone marrow
Externí odkaz:
https://doaj.org/article/d1c99a7f8c7f4d7ab186f53fdfc1db4e
Autor:
Markus Bardua, Claudia Haftmann, Pawel Durek, Kerstin Westendorf, Antje Buttgereit, Cam Loan Tran, Mairi McGrath, Melanie Weber, Katrin Lehmann, Richard Kwasi Addo, Gitta Anne Heinz, Anna-Barbara Stittrich, Patrick Maschmeyer, Helena Radbruch, Michael Lohoff, Hyun-Dong Chang, Andreas Radbruch, Mir-Farzin Mashreghi
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Proinflammatory type 1 T helper (Th1) cells are enriched in inflamed tissues and contribute to the maintenance of chronic inflammation in rheumatic diseases. Here we show that the microRNA- (miR-) 31 is upregulated in murine Th1 cells with a history
Externí odkaz:
https://doaj.org/article/3a3f2b7eb4ae4c198d432b833a7419c0
Autor:
Peter K. Jani, Georg Petkau, Yohei Kawano, Uwe Klemm, Gabriela Maria Guerra, Gitta Anne Heinz, Frederik Heinrich, Pawel Durek, Mir-Farzin Mashreghi, Fritz Melchers
The microRNA cluster-221/222 is expressed in hematopoietic stem cells (HSC) and multipotent progenitors (MPP). To study its function in hematopoiesis, we generated mice, in which this cluster is selectively deleted by Vav-cre in HSC and, thus, in all
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7700e0686ea238d5b279846330ade0e7
https://doi.org/10.1101/2023.01.30.526397
https://doi.org/10.1101/2023.01.30.526397
Autor:
Gitta Anne Heinz, Josefine Radke, Sophie Mc Ewen, V. Moos, Jobst Roehmel, Tilmann Kallinich, Pawel Durek, Daniela Niemeyer, Leif G. Hanitsch, Florian Kurth, Thordis Hohnstein, Uwe Kölsch, Mario Witkowski, Philipp Nawrath, Marcus A. Mall, Frederik Heinrich, Leif E. Sander, Stefan Frischbutter, Mir-Farzin Mashreghi, Tom Aschman, Emanuela Marcenaro, Victor M. Corman, Edoardo Viviano, Sascha Treskatsch, Andreas Diefenbach, Marta Ferreira-Gomes, Marcus Maurer, Christian Meisel, Caroline Tizian, Robert Lorenz Chua, Claudia U. Duerr, Stefan Angermair, Andrey Kruglov, Helena Radbruch, Birgit Sawitzki, Silvia Zocche, Christian Conrad, Andreas Radbruch, Irene Mattiola, Joseph A. Trapani, Thomas Schneider, Christian Drosten, Terry Jones, Kristina Allers
Publikováno v:
Nature. 600:295-301
SARS-CoV-2 is a single-stranded RNA virus that causes coronavirus disease 2019 (COVID-19). Given its acute and often self-limiting course, components of the innate immune system are likely central in controlling virus replication thereby determining
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8ef4688f094e8d16773050add62ca69
https://doi.org/10.1038/s41586-021-04142-6
https://doi.org/10.1038/s41586-021-04142-6
Autor:
Frederik F. Heinrich, Pawel Durek, Vikram Sunkara, Annemarie Lang, Gitta Anne Heinz, Mir-Farzin Mashreghi, Ali Mobasheri
Publikováno v:
Osteoarthritis and Cartilage. 29:905-914
ObjectiveDue to the small size of the murine knee joint, extracting the chondrocyte transcriptome from articular cartilage (AC) is a major technical challenge. In this study, we demonstrate a new and pragmatic approach of combining bulk RNA-sequencin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50b640984b2c8da059e03d3ebe471950
https://doi.org/10.1016/j.joca.2021.03.007
https://doi.org/10.1016/j.joca.2021.03.007
Autor:
Bas Vastert, Alessio Mazzoni, Lorenz Elias Wirth, Tilmann Kallinich, Francesco Giudici, Francesco Annunziato, Pawel Durek, Philipp Enghard, Patrick Maschmeyer, Mir-Farzin Mashreghi, Katrin Lehmann, Sae Lim von Stuckrad, Femke van Wijk, Cam Loan Tran, Andreas Radbruch, Imme Sakwa, Christopher Mark Skopnik, Marcus A. Mall, René Riedel, Hyun-Dong Chang, Lisanne Lutter, Gitta Anne Heinz, Rolando Cimaz, Frederik Heinrich
Publikováno v:
European Journal of Immunology. 51:915-929
T lymphocytes accumulate in inflamed tissues of patients with chronic inflammatory diseases (CIDs) and express pro-inflammatory cytokines upon re-stimulation in vitro. Further, a significant genetic linkage to MHC genes suggests that T lymphocytes pl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c9b482eaf17704a2c3f5070387a87625
https://doi.org/10.1002/eji.202048797
https://doi.org/10.1002/eji.202048797