Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Giti, Garthwaite"'
Publikováno v:
Glia. 63:383-399
In the central nervous system, nitric oxide (NO) transmits signals from one neurone to another, or from neurones to astrocytes or blood vessels, but the possibility of oligodendrocytes being physiological NO targets has been largely ignored. By explo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::422513fcd3be7dbff065020c232f760d
https://doi.org/10.1002/glia.22759
https://doi.org/10.1002/glia.22759
Publikováno v:
Molecular Pharmacology. 61:97-104
In the rat isolated optic nerve, nitric oxide (NO) activates soluble guanylyl cyclase (sGC), resulting in a selective accumulation of cGMP in the axons. The axons are also selectively vulnerable to NO toxicity. The experiments initially aimed to dete
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb7d695aaec9010677b7069270ef089a
https://doi.org/10.1124/mol.61.1.97
https://doi.org/10.1124/mol.61.1.97
Publikováno v:
Neuroscience. 109:145-155
Excessive nitric oxide formation may contribute to the pathology occurring in diseases affecting central white matter. such as multiple sclerosis. The rat isolated optic nerve preparation was used to investigate the potential toxicity of the molecule
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a57f1f23e3a7ea669c9f75cf275834c
https://doi.org/10.1016/s0306-4522(01)00447-x
https://doi.org/10.1016/s0306-4522(01)00447-x
Publikováno v:
Glia
In the central nervous system, nitric oxide (NO) transmits signals from one neurone to another, or from neurones to astrocytes or blood vessels, but the possibility of oligodendrocytes being physiological NO targets has been largely ignored. By explo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e4708f603124b6d457f5adc150c359c8
https://pubmed.ncbi.nlm.nih.gov/25327839
https://pubmed.ncbi.nlm.nih.gov/25327839
Publikováno v:
European Journal of Neuroscience. 11:4367-4372
A major transduction pathway for nitric oxide (NO) is stimulation of soluble guanylyl cyclase and the generation of cyclic GMP (cGMP). In the central nervous system, the NO–cGMP pathway has previously been associated primarily with synapses, partic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4c3707bf0abfd394fb8f773695927c97
https://doi.org/10.1046/j.1460-9568.1999.00874.x
https://doi.org/10.1046/j.1460-9568.1999.00874.x
Autor:
Jeffrey Vernon, Giti Garthwaite, Andrew M. Batchelor, Katalin Bartus, Kathryn L. Harris, Katherine C. Wood, John Garthwaite
Publikováno v:
The Journal of Biological Chemistry
Background: The biological actions of NO depend critically on its concentration, which is very difficult to measure. Results: Recorded using the most sensitive detectors yet described, NO levels synthesized by activated brain neurons generally were i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70aaab11d6d22dd41733eaf59a364809
https://pubmed.ncbi.nlm.nih.gov/22016390
https://pubmed.ncbi.nlm.nih.gov/22016390
Autor:
John Garthwaite, Giti Garthwaite
Publikováno v:
European Journal of Neuroscience. 3:715-728
Excitatory amino acid-induced death of central neurons may be mediated by at least two receptor types, the so-called NMDA (N-methyl-d-aspartate) and AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazoleproprionate) receptors. We have studied the neurodege
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::965de49e629c7fc92aa866ab44a34461
https://doi.org/10.1111/j.1460-9568.1991.tb01668.x
https://doi.org/10.1111/j.1460-9568.1991.tb01668.x
Autor:
Giti Garthwaite, John Garthwaite
Publikováno v:
European Journal of Neuroscience. 3:729-736
The mechanisms underlying the neurodegenerative effects of the glutamate receptor agonist, AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate), were studied using brain slice preparations of young rat (8 - 9 days old) cerebellum and hippocamp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f240020b3346c2b9ac9ad2b7905b3b35
https://doi.org/10.1111/j.1460-9568.1991.tb01669.x
https://doi.org/10.1111/j.1460-9568.1991.tb01669.x
Autor:
Martha Kollb-Sielecka, David A. Goodwin, Chaminda Dooldeniya, Giti Garthwaite, Denise S. Malcolm, Katalin Bartus, John Garthwaite
Brain function is usually perceived as being performed by neurons with the support of glial cells, the network of blood vessels situated nearby serving simply to provide nutrient and to dispose of metabolic waste. Revising this view, we find from exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89697cfdf7ed85865f00f9b7cf4129eb
https://europepmc.org/articles/PMC6674268/
https://europepmc.org/articles/PMC6674268/
Publikováno v:
The European journal of neuroscience. 15(6)
Nitric oxide (NO) may act as a toxin in several neuropathologies, including the brain damage resulting from cerebral ischaemia. Rat striatal slices were used to determine the mechanism of enhanced NO release following simulated ischaemia and, for est
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0044b4d1d22a51aab1d134ef0109076e
https://pubmed.ncbi.nlm.nih.gov/11918655
https://pubmed.ncbi.nlm.nih.gov/11918655