Výsledky vyhledávání - "Githavani Kummari"

Protein kinase A mediates novel serine-584 phosphorylation of HDAC4

Autor: Shanmukha Kumar Doddi, M V Jagannadham, Githavani Kummari, Arunasree M. Kalle

Publikováno v: Biochemistry and Cell Biology. 97:526-535

Given the well-established diversified signaling pathways for histone deacetylase 4 (HDAC4) and the regulation of HDAC4 by several post-translational modifications (PTMs), including phosphorylation, sumoylation, and ubiquitination, an unbiased and de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b8ab2abf92b2d1606424f9a09d8c3c8
https://doi.org/10.1139/bcb-2018-0208

Zobrazit plný text záznamu

Abstract 6368: Discovery of potent, orally bioavailable, SOS1 inhibitors for KRAS-driven tumors

Autor: Sanjita Sasmal, Sukanya Patra, Venkatesham Boorgu, Mahesh Yanamadra, Ashok Ettam, Nagaraju Dunaboyina, Githavani Kummari, Ram Mohan Yengala, Balakrishna Lakhavath, Jayita Das, Satheesh Sunkanapally, Pravalika Reddy, Megha Mariam Mathew

Publikováno v: Cancer Research. 82:6368-6368

KRAS is an oncogene implicated in a wide variety of tumors (~21% of solid tumors harbor KRAS mutations). KRAS interaction with Guanidine Exchange Factors (GEFs) is crucial for its activation, with SOS1 being the predominant GEF. SOS1 inhibition is th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::71ca54c5f437299e08db495e9d7b56ce
https://doi.org/10.1158/1538-7445.am2022-6368

Zobrazit plný text záznamu

Celecoxib potentiates antibiotic uptake by altering membrane potential and permeability in Staphylococcus aureus

Autor: Arunasree M. Kalle, Githavani Kummari, Gajapati Y. N. Varma, Pradip Paik

Publikováno v: The Journal of antimicrobial chemotherapy. 74(12)

Background We have shown previously that celecoxib enhances the antibacterial effect of antibiotics and has sensitized drug-resistant bacteria to antibiotics at low concentrations using in vitro and in vivo model systems and also using clinically iso

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fc0131a54bb882ec77e727e051f4fdd
https://pubmed.ncbi.nlm.nih.gov/31586409

Zobrazit plný text záznamu

HDAC6 promotes PMA-induced megakaryocyte differentiation of K562 cells by regulating ROS levels via NOX4 and repressing Glycophorin A

Autor: Githavani Kummari, Ravi Kumar Gutti, Arunasree M. Kalle

The human erythroleukemia (K562) cells are considered as bipotent megakaryocyte-erythroid progenitor cells and the differentiation of these cells to megakaryocytes (MK) in the presence of phorbol 12-myristate 13-acetate (PMA) mimicsin vivodifferentia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93303dd44d8d8ff55453113bbcc5c1b7

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání