Zobrazeno 1 - 10
of 66
pro vyhledávání: '"Gitali Ganguli-Indra"'
Autor:
Kelsey Pinkham, David Jaehyun Park, Arsalan Hashemiaghdam, Aleksandar B. Kirov, Isam Adam, Kamila Rosiak, Cintia C. da Hora, Jian Teng, Pike See Cheah, Litia Carvalho, Gitali Ganguli-Indra, Avalon Kelly, Arup K. Indra, Christian E. Badr
Publikováno v:
Stem Cell Reports, Vol 12, Iss 4, Pp 712-727 (2019)
Summary: Inherent plasticity and various survival cues allow glioblastoma stem-like cells (GSCs) to survive and proliferate under intrinsic and extrinsic stress conditions. Here, we report that GSCs depend on the adaptive activation of ER stress and
Externí odkaz:
https://doaj.org/article/9886afc7efdb4b3aba3936f75349e152
Publikováno v:
Cells, Vol 11, Iss 13, p 2106 (2022)
Transcriptional regulator BCL11A plays a crucial role in coordinating a suite of developmental processes including skin morphogenesis, barrier functions and lipid metabolism. There is little or no reports so far documenting the role of BCL11A in post
Externí odkaz:
https://doaj.org/article/7a4e4c96733143afa898f9caaa74a5a4
Publikováno v:
Pharmaceutics, Vol 14, Iss 2, p 319 (2022)
Models of skin diseases, such as psoriasis and scleroderma, must accurately recapitulate the complex microenvironment of human skin to provide an efficacious platform for investigation of skin diseases. Skin disease research has been shifting from le
Externí odkaz:
https://doaj.org/article/81726b2dbe1346daaba2f4dd5c01288f
Autor:
Sharmeen Chagani, Rong Wang, Evan L. Carpenter, Christiane V. Löhr, Gitali Ganguli-Indra, Arup K. Indra
Publikováno v:
BMC Cancer, Vol 17, Iss 1, Pp 1-13 (2017)
Abstract Background Understanding the underlying molecular mechanisms involved in the formation of cutaneous malignant melanoma is critical for improved diagnosis and treatment. Keratinocytic nuclear receptor Retinoid X Receptor α (RXRα) has a prot
Externí odkaz:
https://doaj.org/article/7e25df122d754e87b799ae02f27491f5
Autor:
Evan L. Carpenter, Mai N. Le, Cristobal L. Miranda, Ralph L. Reed, Jan F. Stevens, Arup K. Indra, Gitali Ganguli-Indra
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2018)
Exposure to ultraviolet B (UVB) irradiation of the skin leads to numerous dermatological concerns including skin cancer and accelerated aging. Natural product glucosinolate derivatives, like sulforaphane, have been shown to exhibit chemopreventive an
Externí odkaz:
https://doaj.org/article/1a1002b1e5844daab387547eb09a8eac
Autor:
Gunjan Guha, Wanli Lu, Shan Li, Xiaobo Liang, Molly F Kulesz-Martin, Taifo Mahmud, Arup Kumar Indra, Gitali Ganguli-Indra
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0125322 (2015)
Pactamycin, although putatively touted as a potent antitumor agent, has never been used as an anticancer drug due to its high cytotoxicity. In this study, we characterized the effects of two novel biosynthetically engineered analogs of pactamycin, de
Externí odkaz:
https://doaj.org/article/de5c4922ef1041b488ddceb25db2c7fc
Autor:
Daniel J Coleman, Gloria Garcia, Stephen Hyter, Hyo Sang Jang, Sharmeen Chagani, Xiaobo Liang, Lionel Larue, Gitali Ganguli-Indra, Arup K Indra
Publikováno v:
PLoS Genetics, Vol 10, Iss 5, p e1004321 (2014)
Understanding the molecular mechanisms of ultraviolet (UV) induced melanoma formation is becoming crucial with more reported cases each year. Expression of type II nuclear receptor Retinoid-X-Receptor α (RXRα) is lost during melanoma progression in
Externí odkaz:
https://doaj.org/article/18b00d63fbc44ced826febc29a56939a
Autor:
Zhixing Wang, Ling-Juan Zhang, Gunjan Guha, Shan Li, Kateryna Kyrylkova, Chrissa Kioussi, Mark Leid, Gitali Ganguli-Indra, Arup K Indra
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e51262 (2012)
Ctip2 is crucial for epidermal homeostasis and protective barrier formation in developing mouse embryos. Selective ablation of Ctip2 in epidermis leads to increased transepidermal water loss (TEWL), impaired epidermal proliferation, terminal differen
Externí odkaz:
https://doaj.org/article/bba6b08d25ff4a878c356d361da7f0de
Autor:
Xiaobo Liang, Shreya Bhattacharya, Gaurav Bajaj, Gunjan Guha, Zhixing Wang, Hyo-Sang Jang, Mark Leid, Arup Kumar Indra, Gitali Ganguli-Indra
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e29999 (2012)
COUP-TF interacting protein 2 [(Ctip2), also known as Bcl11b] is an important regulator of skin homeostasis, and is overexpressed in head and neck cancer. Ctip2(ep-/-) mice, selectively ablated for Ctip2 in epidermal keratinocytes, exhibited impaired
Externí odkaz:
https://doaj.org/article/281d343037ca4ffb92abddc2bcbc5ff1
Autor:
Gitali Ganguli-Indra, Christine Wasylyk, Xiaobo Liang, Regine Millon, Mark Leid, Bohdan Wasylyk, Joseph Abecassis, Arup K Indra
Publikováno v:
PLoS ONE, Vol 4, Iss 4, p e5367 (2009)
We have demonstrated earlier that CTIP2 is highly expressed in mouse skin during embryogenesis and in adulthood. CTIP2 mutant mice die at birth with epidermal differentiation defects and a compromised epidermal permeability barrier suggesting its rol
Externí odkaz:
https://doaj.org/article/f5f0e9c068d445c5be04dd8f6a87aa4f