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of 33
pro vyhledávání: '"Giso Feussner"'
Autor:
Winfried März, Michael M. Hoffmann, Hubert Scharnagl, Eva Fisher, Minchun Chen, Markus Nauck, Giso Feussner, Heinrich Wieland
Publikováno v:
Journal of Lipid Research, Vol 39, Iss 3, Pp 658-669 (1998)
Using apoE phenotyping by immunoblotting and apoE genotyping we identified four heterozygous carriers of a rare apolipoprotein (apo) E2 variant, apoE2 (Arg136 → Cys). ApoE2 (Arg136 → Cys) was not distinct from apoE2 (Arg158 → Cys) by phenotypin
Externí odkaz:
https://doaj.org/article/2424f9dbbea84e0a8185faeec7d002b7
Autor:
Giso Feussner, H. Schuster
Publikováno v:
Clinical Genetics. 42:302-305
Forty-three patients with clinically and biochemically unequivocally defined type III hyperlipoproteinemia (HLP) were screened for the presence of the apolipoprotein (apo) B-100 arginine3500-->glutamine mutation. This receptor-binding defective apoli
Autor:
Jörg Kreuzer, Egon Werle, Lutz Edler, Konstantinos Cafaltzis, Falk Röder, Ralf Kinscherf, Raoul Breitkreutz, Jürgen Metz, Wulf Hildebrandt, Hans-Peter Deigner, Wulf Dröge, Giso Feussner, Gerd Michel
Publikováno v:
Free Radical Biology and Medicine. 35:1286-1292
Treatment of hyperlipidemic patients with the thiol compound N-acetylcysteine (NAC) was previously shown to cause a significant dose-related increase in the high-density lipoprotein (HDL)-cholesterol serum level, suggesting the possibility that its d
Autor:
Giso Feussner, Ernst J. Schaefer, James R. Barnard, Carl DeLuca, Ilona A. Larson, Jose M. Ordovas
Publikováno v:
Atherosclerosis. 148:327-335
The purpose of this study was to investigate the effects of apolipoprotein (apo) E genotype on plasma apo E levels as well as serum total, low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, triglyceride, and glucos
Autor:
Giso Feussner, Rita Rossol, Martin Rexin, Stefan Klein, Thomas S. Dobmeyer, Jürgen M Dobmeyer
Publikováno v:
Clinica Chimica Acta. 274:119-137
A simple method of obtaining semiquantitative and reliable data on apolipoprotein (apo) sigma gene expression is described. We detected apo sigma specific sequences by reverse transcription (rT)-PCR. For quantitative measurement, an apo sigma DNA sta
Autor:
Martin Rexin, Giso Feussner
Publikováno v:
Clinical Chemistry. 44:773-778
We developed a rapid and simple competitive reverse transcription-polymerase chain reaction for the quantification of apoε mRNA in human monocyte-derived macrophages. The method was applied, and its reliability was shown in patients with the familia
Autor:
Winfried März, Giso Feussner, Jens Lohrmann, Michael M. Hoffmann, Vera Feussner, Heinrich Wieland
Publikováno v:
Human Mutation. 11:417-423
Type III hyperlipoproteinemia (HLP) is usually associated with homozygosity for apolipoprotein (apo) E2 (Arg112 --> Cys, Arg158 --> Cys). This common apo E isoform is defective in its binding to lipoprotein receptors. However, other rare mutations in
Publikováno v:
Genetic Epidemiology. 14:283-297
One hundred forty-seven relatives of 43 patients with "classical" type III hyperlipoproteinemia (HLP) having the apolipoprotein (apo) E2/2 phenotype were studied to determine the occurrence of hyperlipidemia and the presence of further possible genes
Publikováno v:
American Journal of Medical Genetics. 65:149-154
We report on a 20-year-old man with the combination of two independent familial lipoprotein disorders: heterozygous familial hypercholesterolemia (FH) and type III hyperlipoproteinemia (HLP). Familial hypercholesterolemia was diagnosed by elevated to
Autor:
J. Acar, Winfried März, C Scherbaum, J Dobmeyer, H. Scharnagl, Heinrich Wieland, J Lohrmann, Giso Feussner
Publikováno v:
Journal of Lipid Research, Vol 37, Iss 8, Pp 1632-1645 (1996)
A new apolipoprotein (apo) E variant, apoE5 (Glu212–>Lys) was identified in a Turkish family. The variant was due to a point mutation (CAG–>AAG) at the first nucleotide position of the codon encoding amino acid residue 212 of the mature apoE. The