Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Giselle R, Wiggin"'
Autor:
Elvira Diamantopoulou, Sarah Baxendale, Antonio de la Vega de León, Anzar Asad, Celia J Holdsworth, Leila Abbas, Valerie J Gillet, Giselle R Wiggin, Tanya T Whitfield
Publikováno v:
eLife, Vol 8 (2019)
Adgrg6 (Gpr126) is an adhesion class G protein-coupled receptor with a conserved role in myelination of the peripheral nervous system. In the zebrafish, mutation of adgrg6 also results in defects in the inner ear: otic tissue fails to down-regulate v
Externí odkaz:
https://doaj.org/article/700193cc045e4c5a9b04838d6cdce800
Publikováno v:
Genesis (New York, N.Y. : 2000)REFERENCES. 59(4)
Adhesion GPCRs are important regulators of conserved developmental processes and represent an untapped pool of potential targets for drug discovery. The adhesion GPCR Adgrg6 (Gpr126) has critical developmental roles in Schwann cell maturation and inn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de5f76e6bac5bd10d73bc779362759cb
https://pubmed.ncbi.nlm.nih.gov/33735533
https://pubmed.ncbi.nlm.nih.gov/33735533
Autor:
Gabriele Stephan, Caroline Wilde, Norbert Sträter, Niklas Ravn-Boess, Dimitris G. Placantonakis, Giselle R. Wiggin, Devin Bready, Ines Liebscher, Torsten Schöneberg, Joshua D. Frenster, Jordan Wilcox, Bjoern Kieslich
SUMMARYGPR133 (ADGRD1), an adhesion G protein-coupled receptor (GPCR), is necessary for growth of glioblastoma (GBM), a brain malignancy. The extracellular N-terminus of GPR133 is thought to be autoproteolytically cleaved into an N-terminal and a C-t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::444de5b90da68873a1b5b185058e3f33
https://doi.org/10.1101/2020.12.08.415398
https://doi.org/10.1101/2020.12.08.415398
Autor:
Rajan Jain, Matija Snuderl, Danielle Golub, Matt Barnes, Christopher Y. Park, Luis Chiriboga, Michael Kader, Robert H. Newman, Torsten Schöneberg, Dimitris G. Placantonakis, David Fenyö, David Zagzag, Ines Liebscher, Nadim Shohdy, Joshua D. Frenster, Jonathan Serrano, Gabriele Stephan, Niklas Ravn-Boess, Giselle R. Wiggin, James Sun, Devin Bready, Xinyan Huang, Scott Kamen, Douglas MacNeil, John K. Dickson, Sylvia Kurz, Andrew S. Chi
Publikováno v:
Neuro-oncology Advances
Background Glioma is a family of primary brain malignancies with limited treatment options and in need of novel therapies. We previously demonstrated that the adhesion G protein-coupled receptor GPR133 (ADGRD1) is necessary for tumor growth in adult
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1fa72e5b1181bae55e35d07958d0a5a
http://europepmc.org/articles/PMC7262742
http://europepmc.org/articles/PMC7262742
Autor:
Eric A. Sigel, Paolo A. Centrella, Ying Zhang, Stefan Geschwindner, Niek Dekker, Sevan Habeshian, Matthew A. Clark, Cédric Fiez-Vandal, Dawn M. Troast, John W. Cuozzo, Marie-Aude Guié, Linda Sundström, Christoph E. Dumelin, Giselle R. Wiggin, Jing Zhang, Robert M. Cooke, Kaan Certel, Dean G. Brown, Arjan Snijder, Giles A. Brown, Anthony D. Keefe, Oliver Schlenker, Andrew D. Ferguson, Holly T Soutter
Publikováno v:
SLAS Discovery. 23:429-436
The discovery of ligands via affinity-mediated selection of DNA-encoded chemical libraries is driven by the quality and concentration of the protein target. G-protein-coupled receptors (GPCRs) and other membrane-bound targets can be difficult to isol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dd9ba51dee67187363a091e9a4ccc26
https://doi.org/10.1177/2472555217749847
https://doi.org/10.1177/2472555217749847
Autor:
Louis Leong, Benjamin Tehan, Dean G. Brown, Dawn M. Troast, Giles A. Brown, Nils-Olov Hermansson, Peter E. Thornton, Cédric Fiez-Vandal, Holly H. Soutter, Oliver Schlenker, Fiona H. Marshall, Robert M. Cooke, Arjan Snijder, Karl Edman, Christoph Grebner, Giselle R. Wiggin, A.S. Dore, Stefan Geschwindner, Andrei Zhukov, Birte Aggeler, Christoph E. Dumelin, Niek Dekker, Patrik Johansson, Robert K. Y. Cheng, Mathieu Rappas, Ali Jazayeri, Linda Sundström, Rudi Prihandoko
Publikováno v:
Nature. 545:112-115
Crystal structures of protease-activated receptor 2 (PAR2) in complex with two different antagonist ligands and with a blocking antibody reveal binding sites that are distinct from those found on PAR1, offering new leads for structure-based drug desi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60ed03d801965b48c5792271544c4222
https://doi.org/10.1038/nature22309
https://doi.org/10.1038/nature22309
Autor:
Antonio de la Vega de León, Anzar Asad, Sarah Baxendale, Tanya T. Whitfield, Leila Abbas, Valerie J. Gillet, Celia J. Holdsworth, Giselle R. Wiggin, Elvira Diamantopoulou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2c19f1e10cdf4e56a59eca6d7d5b5233
https://doi.org/10.7554/elife.44889.030
https://doi.org/10.7554/elife.44889.030
Autor:
Celia J. Holdsworth, Antonio de la Vega de León, Anzar Asad, Elvira Diamantopoulou, Sarah Baxendale, Tanya T. Whitfield, Leila Abbas, Valerie J. Gillet, Giselle R. Wiggin
Publikováno v:
eLife, Vol 8 (2019)
Adgrg6 (Gpr126) is an adhesion class G protein-coupled receptor with a conserved role in myelination of the peripheral nervous system. In the zebrafish, mutation of adgrg6 also results in defects in the inner ear: otic tissue fails to down-regulate v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82e21de08fe130659f993a6b3e34b21a
https://doi.org/10.1101/520056
https://doi.org/10.1101/520056
Autor:
Dimitris G. Placantonakis, Jordan Wilcox, Joshua D. Frenster, Devin Bready, Torsten Schöneberg, Caroline Wilde, Niklas Ravn-Boess, Ines Liebscher, Giselle R. Wiggin, Bjoern Kieslich, Gabriele Stephan, Norbert Sträter
Publikováno v:
The Journal of Biological Chemistry
GPR133 (ADGRD1), an adhesion G protein–coupled receptor (GPCR) whose canonical signaling activates GαS-mediated generation of cytosolic cAMP, has been shown to be necessary for the growth of glioblastoma (GBM), a brain malignancy. The extracellula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::868791b62042e6e859e70141150a513a
https://doi.org/10.1016/j.jbc.2021.100798
https://doi.org/10.1016/j.jbc.2021.100798
Autor:
John A. Christopher, Maria Josefa Serrano-Vega, James C. Errey, Sarah Joanne Aves, K.A. Bennett, A.S. Dore, Miles Congreve, Fiona H. Marshall, Giselle R. Wiggin, Ali Jazayeri, Krzysztof Okrasa, Benjamin G. Tehan
Publikováno v:
Journal of Medicinal Chemistry. 58:6653-6664
Fragment screening of a thermostabilized mGlu5 receptor using a high-concentration radioligand binding assay enabled the identification of moderate affinity, high ligand efficiency (LE) pyrimidine hit 5. Subsequent optimization using structure-based
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9dbd455d84754902949f45b3890ec17
https://doi.org/10.1021/acs.jmedchem.5b00892
https://doi.org/10.1021/acs.jmedchem.5b00892