Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Giselle M Boukhaled"'
Autor:
Dafna Gladman, Murray Urowitz, David Brooks, Zahi Touma, Joan Wither, Kieran Manion, Zoha Faheem, Carolina Munoz-Grajales, Giselle M Boukhaled, Carol Nassar, Mickael Kim
Publikováno v:
Lupus Science and Medicine, Vol 11, Iss Suppl 2 (2024)
Externí odkaz:
https://doaj.org/article/3a9227abc10e415eb96d334a7627ac2f
Publikováno v:
STAR Protocols, Vol 3, Iss 3, Pp 101643- (2022)
Summary: This is a cytometry by time-of-flight (CyTOF) staining protocol for hematopoietic-derived cells, that leverages live-cell barcoding using receptor-type tyrosine-protein phosphatase C (CD45) antibodies conjugated to metal isotopes in combinat
Externí odkaz:
https://doaj.org/article/317fbfb48ce149088f7a8eb4475eb616
Autor:
Brendan Cordeiro, Peter Jeon, Giselle M. Boukhaled, Mario Corrado, Orsolya Lapohos, Dominic G. Roy, Kelsey Williams, Russell G. Jones, Samantha Gruenheid, Selena M. Sagan, Connie M. Krawczyk
Publikováno v:
Cell Reports, Vol 31, Iss 5, Pp - (2020)
Summary: Dendritic cells, cells of the innate immune system, are found in a steady state poised to respond to activating stimuli. Once stimulated, they rapidly undergo dynamic changes in gene expression to adopt an activated phenotype capable of stim
Externí odkaz:
https://doaj.org/article/bdfb2ccc8fcf48c08209ddf4aa111659
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Epigenetics has widespread implications in a variety of cellular processes ranging from cell identity and specification, to cellular adaptation to environmental stimuli. While typically associated with heritable changes in gene expression, epigenetic
Externí odkaz:
https://doaj.org/article/831565f5182e4e93b425890159b30eba
Autor:
Mengdi Guo, Diala Abd-Rabbo, Bruna Bertol, Madeleine Carew, Sabelo Lukhele, Laura M Snell, Wenxi Xu, Giselle M Boukhaled, Heidi Elsaesser, Marie jo Halaby, Naoto Hirano, Tracy L McGaha, David G Brooks
Publikováno v:
bioRxiv
CD4 T cells are important effectors of anti-tumor immunity, yet the regulation of CD4 tumor-specific T (TTS) cells during cancer development is still unclear. We demonstrate that CD4 TTScells are initially primed in the tumor draining lymph node and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bc68d8039b703b05f19324e33bbb107
https://europepmc.org/articles/PMC10153152/
https://europepmc.org/articles/PMC10153152/
Autor:
Giselle M. Boukhaled, Brendan Cordeiro, Genevieve Deblois, Vassil Dimitrov, Swneke D. Bailey, Thomas Holowka, Anisa Domi, Hannah Guak, Huai-Hsuan Clare Chiu, Bart Everts, Edward J. Pearce, Mathieu Lupien, John H. White, Connie M. Krawczyk
Publikováno v:
Cell Reports, Vol 16, Iss 7, Pp 1829-1837 (2016)
Pro-inflammatory signals provided by the microenvironment are critical to activate dendritic cells (DCs), components of the innate immune system that shape both innate and adaptive immunity. However, to prevent inappropriate immune activation, mechan
Externí odkaz:
https://doaj.org/article/8c33a8fcc6be440dae00c85bc3811e39
Autor:
Dorian B. McGavern, David G. Brooks, Juan Carlos Zúñiga-Pflücker, Mahmood Mohtashami, Heidi Elsaesser, Cameron R. Cunningham, Laura M. Snell, Giselle M. Boukhaled, Ivan Osokine
Publikováno v:
Proc Natl Acad Sci U S A
Chronic infection provokes alterations in inflammatory and suppressive pathways that potentially affect the function and integrity of multiple tissues, impacting both ongoing immune control and restorative immune therapies. Here we demonstrate that c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d65686c934f204a03cf55fc76bf05929
https://doi.org/10.1073/pnas.1913776117
https://doi.org/10.1073/pnas.1913776117
Autor:
Giselle M. Boukhaled, Ramy Gadalla, Heidi J. Elsaesser, Diala Abd-Rabbo, Rene Quevedo, S. Y. Cindy Yang, Mengdi Guo, Ben X. Wang, Babak Noamani, Diana Gray, Sally C. M. Lau, Kirsty Taylor, Kyaw Aung, Anna Spreafico, Aaron R. Hansen, Samuel D. Saibil, Naoto Hirano, Cynthia Guidos, Trevor J. Pugh, Tracy L. McGaha, Pamela S. Ohashi, Adrian G. Sacher, Marcus O. Butler, David G. Brooks
Publikováno v:
Nature immunology. 23(8)
Type I interferons (IFN-Is) are central regulators of anti-tumor immunity and responses to immunotherapy, but they also drive the feedback inhibition underlying therapeutic resistance. In the present study, we developed a mass cytometry approach to q
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fecb364ff53d9b9483fe0541a27e8c59
https://pubmed.ncbi.nlm.nih.gov/35864245
https://pubmed.ncbi.nlm.nih.gov/35864245
Publikováno v:
Annu Rev Pathol
The immune system is tasked with identifying malignant cells to eliminate or prevent cancer spread. This involves a complex orchestration of many immune cell types that together recognize different aspects of tumor transformation and growth. In respo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc7cab67077b79c44d00b343fc5668c1
https://europepmc.org/articles/PMC8063563/
https://europepmc.org/articles/PMC8063563/
Autor:
Giselle M Boukhaled, Ramy Gadalla, Heidi J. Elsaesser, Adrian Sacher, Marcus O Butler, David G. Brooks
Publikováno v:
The Journal of Immunology. 208:180.03-180.03
Type I interferons (IFN-Is) are paradoxically associated with both the success and failure of immune checkpoint blockade (ICB), with increased inflammation in the tumor associated with better response. To understand how IFN-Is modulate the immune res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e078ad3f515103ea89585a959cd58803
https://doi.org/10.4049/jimmunol.208.supp.180.03
https://doi.org/10.4049/jimmunol.208.supp.180.03