Výsledky vyhledávání - "Gisele Sarosy"

Age does not influence taxol dose intensity in recurrent carcinoma of the ovary

Autor: Eddie Reed, Elise C. Kohn, Annette Bicher, Patricia Davis, Debra O. Adamo, Bruce A. Chabner, Gisele Sarosy, Joan Jacob

Publikováno v: Cancer. 71:594-600

In the treatment of advanced-stage ovarian cancer, it is common practice to treat elderly patients in a less aggressive fashion than young patients. This approach is based on the notion that age is associated with poor patient tolerance to aggressive

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02a46b3813fdab25d239af6e34c93ae8
https://doi.org/10.1002/cncr.2820710216

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A Phase I study of paclitaxel and continuous daily CAI in patients with refractory solid tumors

Autor: Herbert L. Kotz, William D. Figg, Miranda Raggio, Nilofer S. Azad, Elise C. Kohn, Alyssa Perroy, Cynthia Graves, Lori M. Minasian, Erin R. Gardner, Chiyo K. Imamura, Gisele Sarosy

Publikováno v: Cancer Biology & Therapy. 8:1800-1805

Carboxyamido-triazole (CAI) is a calcium influx inhibitor with anti-angiogenic and anti-invasive properties and stabilizes tumor progression in patients. We hypothesized daily oral micronized CAI with q3 week paclitaxel would be well-tolerated and ac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dfddc23001a7d5414072451c1f5a500
https://doi.org/10.4161/cbt.8.19.9593

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Phase II Trial of Carboxyamidotriazole in Patients With Relapsed Epithelial Ovarian Cancer

Autor: Lori M. Minasian, Ahalya Premkumar, Gisele Sarosy, Eddie Reed, William D. Figg, Seth M. Steinberg, Vyta Kulpa Oliver, Herbert L. Kotz, Suoping Zhai, Elise C. Kohn, Miranda Raggio, Mahrukh M. Hussain

Publikováno v: Journal of Clinical Oncology. 21:4356-4363

Purpose: Carboxyamidotriazole (CAI) is a cytostatic inhibitor of nonvoltage-operated calcium channels and calcium channel–mediated signaling pathways. It inhibits angiogenesis, tumor growth, invasion, and metastasis. We hypothesized that CAI would

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da69144b90446b6b260bccd51f3fe94d
https://doi.org/10.1200/jco.2003.04.136

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Synchronous inflammatory breast cancer and advanced ovarian carcinoma: A case with prolonged disease-free survival

Autor: Elise C. Kohn, Gisele Sarosy, V. Sandor, Patricia Davis, Eddie Reed, Lavinia P. Middleton

Publikováno v: Annals of Oncology. 10:585-588

Despite the known association of these malignancies, the incidence of a synchronous presentation of breast and ovarian cancer is low, and the current literature does not address an approach to this clinical problem directly. We report a greater than

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d46ef3ad336e534c813685319753918
https://doi.org/10.1023/a:1008239124657

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Dose intensive combination platinum and cyclophosphamide in the treatment of patients with advanced untreated epithelial ovarian cancer

Autor: Jeremy Shapiro, Debra O. Adamo, Gisele Sarosy, Mace L. Rothenberg, Elise C. Kohn, Eddie Reed, Seth M. Steinberg, Robert F. Ozols

Publikováno v: Cancer. 83:1980-1988

BACKGROUND The authors combined cisplatin and carboplatin together with cyclophosphamide to maximize platinum dose intensity in patients with advanced epithelial ovarian cancer (AOC). METHODS The authors treated 26 consecutive, newly diagnosed patien

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::33288952ac888e7aabea83dc662b354a
https://doi.org/10.1002/(sici)1097-0142(19981101)83:9<1980::aid-cncr14>3.0.co

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PHARMACOKINETICS OF ELEMENTAL PLATINUM (ULTRAFILTRATE AND TOTAL) AFTER A THIRTY MINUTE INTRAVENOUS INFUSION OF ORMAPLATIN

Autor: Nathan C. Ryan, Mace Rothenberg, Richard M. Lush, Eddie Reed, William D. Figg, Charles J. Link, Elise C. Kohn, Patricia Davis, Michaele C. Christian, Raymond B. Weiss, Gisele Sarosy, Joan Jacobs

Publikováno v: Biopharmaceutics & Drug Disposition. 18:347-359

Preclinical data suggest that ormaplatin (tetrachloro-(dl-trans)-1, 2-diamminocyclohexaneplatinum) has substantial activity in cisplatin-resistant tumor models and may be less nephrotoxic than cisplatin. Based on these data we initiated a phase I cli

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::65d2a15f46768d8819dc76b0dd610ecf
https://doi.org/10.1002/(sici)1099-081x(199705)18:4<347::aid-bdd23>3.0.co

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Phase I trial of micronized formulation carboxyamidotriazole in patients with refractory solid tumors: pharmacokinetics, clinical outcome, and comparison of formulations

Autor: Gisele Sarosy, Kenneth S. Bauer, M J Soltis, P A Davis, A Thompkins, Eddie Reed, William D. Figg, Lance A. Liotta, Elise C. Kohn

Publikováno v: Journal of Clinical Oncology. 15:1985-1993

PURPOSE Cytostatic agents targeted against angiogenesis and tumor cell invasive potential form a new class of investigational drugs. Orally administered carboxyamidotriazole (CAI) (NSC609974) is both antiangiogenic and antimetastatic. An encapsulated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97bb67f6afe87cd0b70ce754c2f82a60
https://doi.org/10.1200/jco.1997.15.5.1985

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Borderline ovarian tumors

Autor: Charles J. Link, Elise C. Kohn, Gisele Sarosy, Eddie Reed

Publikováno v: The American Journal of Medicine. 101:217-225

Borderline tumor of the ovary (BOT) is an epithelial tumor with a low rate of growth and a low potential to invade or metastasize. This tumor often is associated with a significantly better prognosis than epithelial ovarian cancer. Most tumors are ei

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::947f85f894592c0d6cf650e4a7e731ab
https://doi.org/10.1016/s0002-9343(96)80079-9

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