Zobrazeno 1 - 10 of 23 pro vyhledávání: '"Gisele, Bulhões Portapilla"'
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Akademický článek
The potential of phenothiazinium dyes as cytotoxicity markers in cisplatin-treated cells
Autor: Luiz Miguel Pereira, Gisele Bulhões Portapilla, Guilherme Thomaz Pereira Brancini, Bruna Possato, Cássia Mariana Bronzon da Costa, Péricles Gama Abreu-Filho, Mark Wainwright, Ana Patrícia Yatsuda, Gilberto Úbida Leite Braga
Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-17 (2023)
Abstract Assessing the in vitro toxicity of compounds on cell cultures is an important step during the screening of candidate molecules for diverse applications. Among the strategies employed to determine cytotoxicity, MTT, neutral red, and resazurin
Externí odkaz: https://doaj.org/article/d5610b36671e40b1b0b01b533e55d945
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2
Novel synthetic derivatives of cinnamic and p-coumaric acids with antiproliferative effect on breast MCF-7 tumor cells
Autor: Débora Munhoz Rodrigues, Gisele Bulhões Portapilla, Gabriel Soubihe de Sicco, Iris Fraioli Reis da Silva, Sergio de Albuquerque, Jairo Kenupp Bastos, Vanessa Leiria Campo
p-Coumaric acid is derived from cinnamic acid and is one of the major compounds in the Brazilian green propolis extract. Studies have shown that both p-coumaric acid and cinnamic acid have promising antiproliferative effects. In this context, aiming
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f3448075970a7329747b541bf1698fd
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3
Melatonin decreases circulating Trypanosoma cruzi load with no effect on tissue parasite replication
Autor: Gisele Bulhões Portapilla, Carla Brigagão Pacheco da Silva, Sérgio de Albuquerque, Naira Ferreira Anchieta, Maiara Voltarelli Providello, Carlos R. Tirapelli, Pedro Alexandre Sampaio Oliveira
Publikováno v: Canadian Journal of Physiology and Pharmacology. 99:795-802
Cardiac damage during the acute phase of Chagas disease (CD) is associated with an increase in pro-inflammatory markers and oxidative stress. Melatonin (MEL) has emerged as a promising therapy for CD due to its antioxidant and immunomodulatory proper
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3b3d78eb486bd5bb0e0bfcfdebc9b325
https://doi.org/10.1139/cjpp-2020-0473
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4
Synthesis and Antitrypanosomal Activity of 1,4‐Disubstituted Triazole Compounds Based on a 2‐Nitroimidazole Scaffold: a Structure‐Activity Relationship Study
Autor: Gisele Bulhões Portapilla, Sérgio de Albuquerque, Elvis L. F. Assunção, Amarith R. das Neves, Cristiane Y. Kawasoko Shiguemotto, Adriano C. M. Baroni, Diego B. Carvalho
Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Chagas disease affects 6-8 million people worldwide, remaining a public health concern. Toxicity, several adverse effects and inefficiency in the chronic stage of the disease are the major challenges regarding the available treatment protocols. This
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::feaafaf452dc5dab2f2240d24619e144
https://doi.org/10.1002/cmdc.202000460
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6
Phenothiazinium Dyes Are Active againstTrypanosoma cruziIn Vitro
Autor: Sérgio de Albuquerque, Maiara Voltarelli Providello, Mark Wainwright, Pedro Alexandre Sampaio Oliveira, Gilberto U.L. Braga, Gisele Bulhões Portapilla, Amanda Goulart, Cássia Mariana Bronzon da Costa, Luiz Miguel Pereira, Naira Ferreira Anchieta
Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
BioMed Research International, Vol 2019 (2019)
Chagas disease is a tropical illness caused by the protozoanTrypanosoma cruzi. The disease affects populations of the Americas and has been spread to other continents due to the migration process. The disease is partially controlled by two drugs, Ben
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12ceb548d37a166e14f60e6a719695e4
https://doi.org/10.1155/2019/8301569
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7
Trypanocidal activity of new 1,6-diphenyl-1H-pyrazolo[3,4-b]pyridine derivatives: synthesis, in vitro and in vivo studies
Autor: Gisele Bulhões Portapilla, Luiza R.S. Dias, Júlio C. A. V. Soares, Estela M.F. Muri, Camilo Henrique da Silva Lima, Maiara Voltarelli Providello, Sérgio de Albuquerque, Joana Lucius de Sousa Ribeiro
Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Despite the serious public health problems caused by Chagas disease in several countries, the available therapy remains with only two drugs that are poorly active during the chronic phase of the disease in addition to having severe side effects. In s
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::326202b3ea4243d9053566a539950666
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8
Synthesis, antitumor activity and in silico analyses of amino acid derivatives of artepillin C, drupanin and baccharin from green propolis
Autor: Sérgio de Albuquerque, Gisele Bulhões Portapilla, Carlos Henrique Tomich de Paula da Silva, Débora Munhoz Rodrigues, Guilherme Martins Silva, Andressa Duarte, Cristiana Gonçalez Rotta, Jairo Kenupp Bastos, Vanessa Leiria Campo
Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Breast cancer has the highest incidence and mortality in females, while prostate cancer has the second-highest incidence in males. Studies have shown that compounds from Brazilian green propolis have antitumor activities and can selectively inhibit t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba9e6d650d95e17f178a44e0814266b7
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9
Melatonin decreases circulating
Autor: Maiara Voltarelli, Providello, Gisele Bulhões, Portapilla, Pedro Alexandre Sampaio, Oliveira, Carla Brigagão Pacheco, da Silva, Naira Ferreira, Anchieta, Carlos Renato, Tirapelli, Sérgio, de Albuquerque
Publikováno v: Canadian journal of physiology and pharmacology. 99(8)
Cardiac damage during the acute phase of Chagas disease (CD) is associated with an increase in pro-inflammatory markers and oxidative stress. Melatonin (MEL) has emerged as a promising therapy for CD due to its antioxidant and immunomodulatory proper
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::aaba51ba0bdcd8a3211f9bfa0ac361cc
https://pubmed.ncbi.nlm.nih.gov/33296274
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10
In vitro EFFECTS OF SODIUM SELENITE SUPPLEMENTATION ON CELL VIABILITY OF DIFFERENT FORMS OF Trypanosoma cruzi
Autor: Gisele Bulhões Portapilla, Marco Túlio Alves da Silva, Otavio Henrique Thiemann, Alan Raphael de Farias Klein Moraes
Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Selenium is an essential trace element which, at adequate levels, presents different beneficial biological effects, such as cancer regression, tissue development and protection against oxidative damage. The positive effects of this element are relate
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce1892445e362c1ea04e6c478ea900b5
https://doi.org/10.5216/rpt.v49i2.61410
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