Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Gisela Weiz"'
Autor:
Gisela Weiz, Alina L. González, Iara S. Mansilla, Martín E. Fernandez-Zapico, María I. Molejón, Javier D. Breccia
Publikováno v:
Microbial Cell Factories, Vol 23, Iss 1, Pp 1-12 (2024)
Abstract Background Low targeting efficacy and high toxicity continue to be challenges in Oncology. A promising strategy is the glycosylation of chemotherapeutic agents to improve their pharmacodynamics and anti-tumoral activity. Herein, we provide e
Externí odkaz:
https://doaj.org/article/92e6ac2312754718aee698c787a9a328
Autor:
Gisela Weiz, Alina L. Gonzalez, Flavia Piccioni, Mariel Fusco, Marco Diaz Gutiérrez, Guillermo Mazzolini, Javier D. Breccia, Mariana Malvicini, Maria I. Molejon
Publikováno v:
Cancer Research. 82:5447-5447
Hepatocellular carcinoma (HCC) is the fourth leading cause of cancer-related death worldwide, and is particularly refractory to the available therapeutic drugs. Unfortunately, curative treatments such as surgery, liver transplantation, or ablation ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::53a66e75b0827fe9da7d48b183b8ffbd
https://doi.org/10.1158/1538-7445.am2022-5447
https://doi.org/10.1158/1538-7445.am2022-5447
Publikováno v:
World Journal of Clinical Oncology
Cancer constitutes the second leading cause of death globally and is considered to have been responsible for an estimated 9.6 million fatalities in 2018. Although treatments against gastrointestinal tumors have recently advanced, those interventions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6109fc1fb1c1e5165080b13abf060d6e
http://europepmc.org/articles/PMC7103525
http://europepmc.org/articles/PMC7103525
Autor:
Claudio Tiribelli, Javier D. Breccia, Maria I Molejon, Caecilia H. C. Sukowati, Gisela Weiz, Mariana Malvicini, Guillermo Mazzolini
Publikováno v:
Liver international : official journal of the International Association for the Study of the LiverREFERENCES. 42(2)
Background & aims Reaching efficacious drug delivery to target cells/tissues represents a major obstacle in the current treatment of solid malignancies including hepatocellular carcinoma (HCC). In this study, we developed a pipeline to selective add
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28887cda6d5669dbbe3590933d8d68ef
https://pubmed.ncbi.nlm.nih.gov/34800352
https://pubmed.ncbi.nlm.nih.gov/34800352
Autor:
Lucas Braun, Helena Pelantová, Javier D. Breccia, Vladimír Křen, Michael Kotik, Laura S. Mazzaferro, Gisela Weiz
Publikováno v:
Biotechnology and Applied Biochemistry. 66:53-59
The structure of the carbohydrate moiety of a natural phenolic glycoside can have a significant effect on the molecular interactions and physicochemical and pharmacokinetic properties of the entire compound, which may include anti-inflammatory and an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::812c302ee8f4e820ca28b1c653ba2112
https://doi.org/10.1002/bab.1695
https://doi.org/10.1002/bab.1695
Autor:
Gisela Weiz, Javier D. Breccia, Michael Kotik, Barbara Daniela Neher, Laura S. Mazzaferro, Vladimír Křen, Petr Halada
Diglycosidases hydrolyze the heterosidic linkage of diglycoconjugates, releasing the disaccharide and the aglycone. Usually, these enzymes do not hydrolyze or present only low activities towards monoglycosylated compounds. The flavonoid degrading fun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f136e2313f9746375ffc64cb6707b304
https://link.springer.com/article/10.1007/s00253-019-10180-y
https://link.springer.com/article/10.1007/s00253-019-10180-y
Publikováno v:
Journal of Molecular Catalysis B: Enzymatic. 130:70-73
The low solubility of glycosylated flavonoids represents a hurdle to conduct efficient enzymatic deglycosylations in aqueous media. To overcome this drawback, environmentally-unfriendly dimethylsulfoxide (DMSO) is typically used as co-solvent. Using
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7aeab3899fa986cbbdd6333e5689db38
https://doi.org/10.1016/j.molcatb.2016.04.010
https://doi.org/10.1016/j.molcatb.2016.04.010
Autor:
Gisela Weiz
Publikováno v:
SEDICI (UNLP)
Universidad Nacional de La Plata
instacron:UNLP
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Universidad Nacional de La Plata
instacron:UNLP
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Los flavonoides son metabolitos secundarios vegetales y, como tales, son ubicuos en los ecosistemas. En general, se encuentran glicosilados y en su reciclo natural, la desglicosilación es el primer paso catabólico seguido de la oxidación de la est
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c73ab60c760c046d5636b261d79ff3a1
http://sedici.unlp.edu.ar/handle/10915/67995
http://sedici.unlp.edu.ar/handle/10915/67995
Autor:
Laura S, Mazzaferro, Gisela, Weiz, Lucas, Braun, Michael, Kotik, Helena, Pelantová, Vladimír, Křen, Javier D, Breccia
Publikováno v:
Biotechnology and applied biochemistry. 66(1)
The structure of the carbohydrate moiety of a natural phenolic glycoside can have a significant effect on the molecular interactions and physicochemical and pharmacokinetic properties of the entire compound, which may include anti-inflammatory and an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::67542ab4e0bc8b0c7e792cb3e4d94f36
https://pubmed.ncbi.nlm.nih.gov/30294837
https://pubmed.ncbi.nlm.nih.gov/30294837
Rutin is a plant flavonoid constituted by the flavonol quercetin 3-O-linked to the disaccharide rutinose (quercetin 3-O-(6-O-α-L-rhamnopyranosyl-β-D-glucopyranoside)). The enzymatic deglycosylation of rutin is usually assessed by means of the stand
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce37003ae15da0cfd7b0e8035bce548d
https://www.sciencedirect.com/science/article/pii/S0308814617302170
https://www.sciencedirect.com/science/article/pii/S0308814617302170