Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Gisela Ileana Mazaira"'
Publikováno v:
Trends in Endocrinology & Metabolism. 32:827-838
Steroid receptors form soluble heterocomplexes with the 90-kDa heat-shock protein (Hsp90) and other chaperones and co-chaperones. The assembly and composition of the oligomer is influenced by the presence and nature of the bound steroid. Although the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56480752db8a347c155d07e152ef0090
https://doi.org/10.1016/j.tem.2021.07.005
https://doi.org/10.1016/j.tem.2021.07.005
Autor:
Pappu S Swapanthi, Deshetti Bhagya, Gisela Ileana Mazaira, C. V. S. Subrahmanyam, Mario D. Galigniana, N. L. Gowrishankar, Sayan Dutta Gupta, Nulgumnalli Manjunathaiah Raghavendra, Fernando Federicci
Publikováno v:
Anti-Cancer Agents in Medicinal Chemistry. 20:369-385
Background: Heat shock protein 90 (Hsp90) is an encouraging anticancer target for the development of clinically significant molecules. Schiff bases play a crucial role in anticancer research because of their ease of synthesis and excellent antiprolif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66f8443f34cf79ab54d1a7e31eebcb07
https://doi.org/10.2174/1871520619666191111152050
https://doi.org/10.2174/1871520619666191111152050
Publikováno v:
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Pathophysiologic conditions of neurodegenerative diseases are unquestionably related to protein misfolding. The accumulation of misfolded proteins into relatively ordered structures such as fibrillar intracellular and extracellular amyloids results i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13b2ac53c6c680320c4fb066c0302fb6
https://pubmed.ncbi.nlm.nih.gov/33390129
https://pubmed.ncbi.nlm.nih.gov/33390129
Publikováno v:
Journal of Cell Science, Vol. 133, No jcs238873 (2020) pp. 1-12
It has been demonstrated that tetratricopeptide repeats (TPR)-domain proteins regulate the subcellular localization of the glucocorticoid receptor (GR). This study analyses the influence of the TPR-domain of high molecular weight immunophilins in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33f5a003df37dfe323c8cad85d803205
https://archive-ouverte.unige.ch/unige:138332
https://archive-ouverte.unige.ch/unige:138332
Publikováno v:
Methods in Molecular Biology ISBN: 9781493991945
Steroid receptors are members of a subfamily of the nuclear receptor superfamily. They play a dual role of steroid hormone receptors and transcription factors. Actually, these receptors are steroid-activated transcription factors. Classical soluble r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e293659d73a0e814c7103c680451c45c
https://doi.org/10.1007/978-1-4939-9195-2_10
https://doi.org/10.1007/978-1-4939-9195-2_10
Autor:
Nadia R Zgajnar, Gisela Ileana Mazaira, Jeffrey C. Sivils, Marc B. Cox, Mario D. Galigniana, Cristina Daneri-Becerra, Cecilia M Lotufo, Olga B. Soto
Publikováno v:
Methods in Molecular Biology ISBN: 9781493991945
In this chapter, we summarize the birth of the field of nuclear receptors. These receptors exhibit a multitude of roles in cell biology and hence have attracted a great deal of interest in the drug discovery field. It is not certain whether these rec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::26731cf1f7cd9a924d07862b2a156652
https://doi.org/10.1007/978-1-4939-9195-2_1
https://doi.org/10.1007/978-1-4939-9195-2_1
Autor:
Nadia R Zgajnar, Gisela Ileana Mazaira, Alejandra G. Erlejman, Mario D. Galigniana, Sonia A. De Leo
The identification of new factors that may function as cancer markers and becomeeventual pharmacologic targets is a challenge that may influence the management of tumor developmentand management. Recent discoveries connecting Hsp90-binding immunophil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad400449584a65469a710bce2998c35c
https://www.eurekaselect.com/node/168707/article/role-of-the-hsp90-immunophilin-heterocomplex-in-cancer-biology
https://www.eurekaselect.com/node/168707/article/role-of-the-hsp90-immunophilin-heterocomplex-in-cancer-biology
Autor:
Martin Monte, Gisela Ileana Mazaira, Alejandra G. Erlejman, Luciana Gallo, Pablo Christian Echeverria, Mario D. Galigniana, Sol M. Ciucci
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1868:119000
A dimer of the heat-shock protein of 90-kDa (Hsp90) represents the critical core of the chaperone complex associated to the glucocorticoid receptor (GR) oligomer. The C-terminal end of the Hsp90 dimer shapes a functional acceptor site for co-chaperon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::331bcfaf39af3462c21134c7a32cadf6
https://doi.org/10.1016/j.bbamcr.2021.119000
https://doi.org/10.1016/j.bbamcr.2021.119000
Autor:
Nadia R Zgajnar, Gisela Ileana Mazaira, Jeffrey C. Sivils, Cristina Daneri-Becerra, Mario D. Galigniana, Olga B. Soto, Cecilia M Lotufo, Marc B. Cox
Publikováno v:
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Nuclear receptor research
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Nuclear receptor research
In this article we summarize the birth of the field of nuclear receptors, the discovery ofuntransformed and transformed isoforms of ligand-binding macromolecules, the discovery of thethree-domain structure of the receptors, and the properties of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::554c1df3c1ed673a5aafd53d720a4949
https://doi.org/10.11131/2018/101320
https://doi.org/10.11131/2018/101320
Autor:
Manish Kumar Bommaka, Gisela Ileana Mazaira, C. V. S. Subrahmanyam, Sayan Dutta Gupta, Nulgumnalli Manjunathaiah Raghavendra, N. L. Gowrishankar, Mario D. Galigniana
Publikováno v:
International Journal of Biological Macromolecules. 80:253-259
The ubiquitously expressed heat shock protein 90 is an encouraging target for the development of novel anticancer agents. In a program directed towards uncovering novel chemical scaffolds against Hsp90, we performed molecular docking studies using Tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c739dc1a772613ecb9c91e116651787
https://doi.org/10.1016/j.ijbiomac.2015.06.039
https://doi.org/10.1016/j.ijbiomac.2015.06.039