Altered serotonin innervation in the rat epileptic brain

Autor: Nikolai V. Lukoyanov, Joana I. Soares, Sérgio G. Almeida, Juliana M. Leite, Alisa N. Lukoyanova, Helena X. Baptista, Gisela H. Maia, Cátia S. Brazete

Publikováno v: Brain Research Bulletin. 152:95-106

Studies in animal models of epilepsy revealed compromised serotonin (5-HT) transmission between the raphe nuclei and the brain limbic system. The goal of the present study was to evaluate the effects of epilepsy on the structural integrity of the dor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a26121f2aef62db89338ce309b9836d7
https://doi.org/10.1016/j.brainresbull.2019.07.009

Unilateral brain injury to pregnant rats induces asymmetric neurological deficits in the offspring

Autor: Gisela H. Maia, Georgy Bakalkin, Liliana S Carvalho, Nikolay Lukoyanov, Mengliang Zhang, Elena A Lukoyanova, Olga Nosova, Daniil Sarkisyan, Helena M Brito

Publikováno v: Carvalho, L S, Brito, H M, Lukoyanova, E A, Maia, G H, Sarkisyan, D, Nosova, O, Zhang, M, Lukoyanov, N & Bakalkin, G 2021, ' Unilateral brain injury to pregnant rats induces asymmetric neurological deficits in the offspring ', European Journal of Neuroscience, vol. 53, no. 11, pp. 3621-3633 . https://doi.org/10.1111/ejn.15243

Effects of environmental factors may be transmitted to the following generation, and cause neuropsychiatric disorders including depression, anxiety, and posttraumatic stress disorder in the offspring. Enhanced synaptic plasticity induced by environme

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7e1219c8b854116f2196940fdefb59b
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-454195

Partial depletion of septohippocampal cholinergic cells reduces seizure susceptibility, but does not mitigate hippocampal neurodegeneration in the kainate model of epilepsy

Autor: Pedro Andrade, Nikolai V. Lukoyanov, Catarina Da Costa, Maria H. Ferreira, Gisela H. Maia, Joana I. Soares

Publikováno v: Brain research. 1717

The brain cholinergic system may undergo structural and functional alterations both in human epilepsy and in respective animal models, but the causal relationships between these alterations and epilepsy remain to be established. In this study, we att

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2371e28c5593470a316f93c2f18b666
https://pubmed.ncbi.nlm.nih.gov/31028730

The pedunculopontine and laterodorsal tegmental nuclei in the kainate model of epilepsy

Autor: Gisela H. Maia, Joana I. Soares, Ana R. Afonso, Nikolai V. Lukoyanov

Publikováno v: Neuroscience letters. 672

Prior studies showed that epilepsy can be associated with reorganization of the septohippocampal cholinergic fiber system. Using the kainate model of epilepsy, we wished to further examine the structural integrity of the mesopontine tegmental nuclei

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c82aa2124d58f04acd7fa44cf5ffbfcd
https://pubmed.ncbi.nlm.nih.gov/29476797

Loss of hippocampal neurons after kainate treatment correlates with behavioral deficits

Autor: Joana M. do Carmo, Pedro Andrade, Gisela H. Maia, José Paulo Andrade, Nikolai V. Lukoyanov, José L. Quesado, Joana I. Soares

Publikováno v: PLoS ONE, Vol 9, Iss 1, p e84722 (2014)
PLoS ONE

Treating rats with kainic acid induces status epilepticus (SE) and leads to the development of behavioral deficits and spontaneous recurrent seizures later in life. However, in a subset of rats, kainic acid treatment does not induce overt behaviorall

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18ea964cc50385742942eeb33006cef7
http://europepmc.org/articles/PMC3883667?pdf=render