Zobrazeno 1 - 10
of 116
pro vyhledávání: '"Gisela Grecksch"'
Improved learning and memory in aged mice deficient in amyloid beta-degrading neutral endopeptidase.
Autor:
Thomas Walther, Doris Albrecht, Matthias Becker, Manja Schubert, Elena Kouznetsova, Burkard Wiesner, Björn Maul, Reinhard Schliebs, Gisela Grecksch, Jens Furkert, Anja Sterner-Kock, Heinz-Peter Schultheiss, Axel Becker, Wolf-Eberhard Siems
Publikováno v:
PLoS ONE, Vol 4, Iss 2, p e4590 (2009)
BackgroundNeutral endopeptidase, also known as neprilysin and abbreviated NEP, is considered to be one of the key enzymes in initial human amyloid-beta (Abeta) degradation. The aim of our study was to explore the impact of NEP deficiency on the initi
Externí odkaz:
https://doaj.org/article/dd9c715bc1034a5fa52e7b851539303a
Publikováno v:
Behavioural Brain Research. 281:62-68
Serotonergic hallucinogens, such as lysergic acid diethylamide (LSD) and dimethoxy-bromoamphetamine (DOB), provoke stereotype-like shaking behaviour in rodents, which is hypothesised to engage frontocortical glutamate receptor activation secondary to
Publikováno v:
Behavioural Brain Research. 270:125-130
SKAP-HOM is an adapter protein which regulates the cross-talk between immunoreceptors and integrins and is involved in signal transduction. It is present in murine brain structures such as the hippocampus, frontal cortex, and cerebellum. In the prese
Publikováno v:
Journal of Psychopharmacology. 28:545-552
A re-balance of postsynaptic serotonin (5-HT) receptor signalling, with an increase in 5-HT1A and a decrease in 5-HT2A signalling, is a final common pathway multiple antidepressants share. Given that the 5-HT1A/2A agonist lysergic acid diethylamide (
Autor:
Michael Karl Boettger, Axel Becker, Nils Gebhardt, Rupert Reichart, Gisela Grecksch, Karl-Jürgen Bär, Gerburg Keilhoff
Publikováno v:
Brain Stimulation, Vol 6, Iss 1, Pp 78-83 (2013)
Background Vagus nerve stimulation (VNS) has been introduced as a therapeutic option for treatment-resistant depression. The neural and chemical mechanisms responsible for the effects of VNS are largely unclear. Methods Bilateral removal of the olfac
The first reports on tolerance to the serotonergic hallucinogen lysergic acid diethylamide (LSD) were published half a century ago, yet hitherto, a systematic review on this topic is not available. In this chapter, we discuss tolerance to LSD with re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::528227cd999cdf3c27fc6960f86fba87
https://doi.org/10.1016/b978-0-12-800212-4.00079-0
https://doi.org/10.1016/b978-0-12-800212-4.00079-0
Publikováno v:
Psychoneuroendocrinology. 34:S258-S264
Summary Transient prenatal vitamin D deficiency is considered a neurodevelopmental animal model in schizophrenia research. Vitamin D deficiency in female rats causes morphological, cellular and molecular changes in the brain and alters behaviour and
Publikováno v:
European Archives of Psychiatry and Clinical Neuroscience. 260:151-162
Altered neuroplasticity contributes to the pathophysiology of schizophrenia. However, the idea that antipsychotics may act, at least in part, by normalizing neurogenesis has not been consistently supported. Our study seeks to determine whether hippoc
Autor:
Ulrich Schmitt, Christoph Hiemke, Gisela Grecksch, Axel Becker, Elisabeth Ladstaetter, Gerald Zernig
Publikováno v:
Psychopharmacology. 202:579-587
Rationale The ketamine (ket) model reflects features of schizophrenia as well as secondary symptoms such as altered pain sensitivity. Objectives In the present study, we investigated the effect of subchronic oral treatment with haloperidol (hal, 0.07
Publikováno v:
Medicinal Chemistry. 4:256-263
The neurotrophic factors play an important role in the maintenance of neurone viability and neuronal communication which are considered to be altered in schizophrenia. Subchronic application of ketamine (Ket) was found to be a useful model in schizop