Delivery of oligonucleotide‐based therapeutics: challenges and opportunities

Autor: Suzan M Hammond, Annemieke Aartsma‐Rus, Sandra Alves, Sven E Borgos, Ronald A M Buijsen, Rob W J Collin, Giuseppina Covello, Michela A Denti, Lourdes R Desviat, Lucía Echevarría, Camilla Foged, Gisela Gaina, Alejandro Garanto, Aurelie T Goyenvalle, Magdalena Guzowska, Irina Holodnuka, David R Jones, Sabine Krause, Taavi Lehto, Marisol Montolio, Willeke Van Roon‐Mom, Virginia Arechavala‐Gomeza

Publikováno v: EMBO Molecular Medicine, Vol 13, Iss 4, Pp 1-23 (2021)

Abstract Nucleic acid‐based therapeutics that regulate gene expression have been developed towards clinical use at a steady pace for several decades, but in recent years the field has been accelerating. To date, there are 11 marketed products based

Externí odkaz: https://doaj.org/article/76e52486fd764de6bb07b4e5106b079a

Combining Protein Expression and Molecular Data Improves Mutation Characterization of Dystrophinopathies

Autor: Gisela Gaina, Rolf H. A. M. Vossen, Emilia Manole, Doina Anca Plesca, Elena Ionica

Publikováno v: Frontiers in Neurology, Vol 12 (2021)

Duchenne and Becker muscular dystrophy are X-linked recessive inherited disorders characterized by progressive weakness due to skeletal muscle degeneration. Different mutations in the DMD gene, which encodes for dystrophin protein, are responsible fo

Externí odkaz: https://doaj.org/article/ea1ac177079d4302b599fa054f790739

Macrophages and Stem Cells—Two to Tango for Tissue Repair?

Autor: Emilia Manole, Cristina Niculite, Ioana Maria Lambrescu, Gisela Gaina, Octavian Ioghen, Laura Cristina Ceafalan, Mihail Eugen Hinescu

Publikováno v: Biomolecules, Vol 11, Iss 5, p 697 (2021)

Macrophages (MCs) are present in all tissues, not only supporting homeostasis, but also playing an important role in organogenesis, post-injury regeneration, and diseases. They are a heterogeneous cell population due to their origin, tissue specifici

Externí odkaz: https://doaj.org/article/f67cf34c49354a39b1e6fccce4ac5e27

Contribution of Epithelial and Gut Microbiome Inflammatory Biomarkers to the Improvement of Colorectal Cancer Patients' Stratification

Autor: Elena Ionica, Gisela Gaina, Mihaela Tica, Mariana-Carmen Chifiriuc, Gratiela Gradisteanu-Pircalabioru

Publikováno v: Frontiers in Oncology, Vol 11 (2022)

In order to ensure that primary endpoints of clinical studies are attained, the patients’ stratification is an important aspect. Selection criteria include age, gender, and also specific biomarkers, such as inflammation scores. These criteria are n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::609b41523067e1be1cab167300708dc2
https://pubmed.ncbi.nlm.nih.gov/35198435

Delivery of oligonucleotide‐based therapeutics: challenges and opportunities

Autor: Annemieke Aartsma-Rus, Marisol Montolio, Gisela Gaina, Camilla Foged, Suzan M. Hammond, Alejandro Garanto, David R. Jones, Lourdes R. Desviat, Giuseppina Covello, Sabine Krause, Magdalena Guzowska, Virginia Arechavala-Gomeza, Sven Even F. Borgos, Willeke M. C. van Roon-Mom, Taavi Lehto, Sandra Alves, Ronald A.M. Buijsen, Michela A. Denti, Aurélie Goyenvalle, Rob W.J. Collin, Irina Holodnuka, Lucia Echevarria

Publikováno v: EMBO Molecular Medicine, Vol 13, Iss 4, Pp n/a-n/a (2021)
EMBO Molecular Medicine
EMBO Molecular Medicine, Wiley Open Access, 2021, 13 (4), ⟨10.15252/emmm.202013243⟩
e13243
EMBO Molecular Medicine, 13
Digital.CSIC. Repositorio Institucional del CSIC
instname
EMBO Molecular Medicine, 13(4). WILEY
Hammond, S M, Aartsma-Rus, A, Alves, S, Borgos, S E, Buijsen, R A M, Collin, R W J, Covello, G, Denti, M A, Desviat, L R, Echevarría, L, Foged, C, Gaina, G, Garanto, A, Goyenvalle, A T, Guzowska, M, Holodnuka, I, Jones, D R, Krause, S, Lehto, T, Montolio, M, Van Roon-Mom, W & Arechavala-Gomeza, V 2021, ' Delivery of oligonucleotide-based therapeutics : challenges and opportunities ', EMBO Molecular Medicine, vol. 13, no. 4, e13243 . https://doi.org/10.15252/emmm.202013243
Biblos-e Archivo. Repositorio Institucional de la UAM
EMBO Molecular Medicine, 13, 4

Nucleic acid‐based therapeutics that regulate gene expression have been developed towards clinical use at a steady pace for several decades, but in recent years the field has been accelerating. To date, there are 11 marketed products based on antis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6de046d4014872f097c116dd271d0d7
https://doi.org/10.15252/emmm.202013243