Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Gisela G Slaats"'
Autor:
Teunis J P van Dam, Julie Kennedy, Robin van der Lee, Erik de Vrieze, Kirsten A Wunderlich, Suzanne Rix, Gerard W Dougherty, Nils J Lambacher, Chunmei Li, Victor L Jensen, Michel R Leroux, Rim Hjeij, Nicola Horn, Yves Texier, Yasmin Wissinger, Jeroen van Reeuwijk, Gabrielle Wheway, Barbara Knapp, Jan F Scheel, Brunella Franco, Dorus A Mans, Erwin van Wijk, François Képès, Gisela G Slaats, Grischa Toedt, Hannie Kremer, Heymut Omran, Katarzyna Szymanska, Konstantinos Koutroumpas, Marius Ueffing, Thanh-Minh T Nguyen, Stef J F Letteboer, Machteld M Oud, Sylvia E C van Beersum, Miriam Schmidts, Philip L Beales, Qianhao Lu, Rachel H Giles, Radek Szklarczyk, Robert B Russell, Toby J Gibson, Colin A Johnson, Oliver E Blacque, Uwe Wolfrum, Karsten Boldt, Ronald Roepman, Victor Hernandez-Hernandez, Martijn A Huynen
Publikováno v:
PLoS ONE, Vol 14, Iss 5, p e0216705 (2019)
The cilium is an essential organelle at the surface of mammalian cells whose dysfunction causes a wide range of genetic diseases collectively called ciliopathies. The current rate at which new ciliopathy genes are identified suggests that many ciliar
Externí odkaz:
https://doaj.org/article/206fb09f592a41a7979de76d71996765
Autor:
Gisela G Slaats, Amiya K Ghosh, Lucas L Falke, Stéphanie Le Corre, Indra A Shaltiel, Glenn van de Hoek, Timothy D Klasson, Marijn F Stokman, Ive Logister, Marianne C Verhaar, Roel Goldschmeding, Tri Q Nguyen, Iain A Drummond, Friedhelm Hildebrandt, Rachel H Giles
Publikováno v:
PLoS Genetics, Vol 10, Iss 10, p e1004594 (2014)
We recently reported that centrosomal protein 164 (CEP164) regulates both cilia and the DNA damage response in the autosomal recessive polycystic kidney disease nephronophthisis. Here we examine the functional role of CEP164 in nephronophthisis-relat
Externí odkaz:
https://doaj.org/article/8629e9b555ce48b0b8ca20f4fda80cc6
Autor:
Floor A. A. Ruiter, Francis L. C. Morgan, Nadia Roumans, Anika Schumacher, Gisela G. Slaats, Lorenzo Moroni, Vanessa L. S. LaPointe, Matthew B. Baker
Publikováno v:
Advanced Science, Vol 9, Iss 20, Pp n/a-n/a (2022)
Abstract Pluripotent stem cell‐derived kidney organoids offer a promising solution to renal failure, yet current organoid protocols often lead to off‐target cells and phenotypic alterations, preventing maturity. Here, various dynamic hydrogel arc
Externí odkaz:
https://doaj.org/article/1e32bb9143d840749074c81db86f3a5e
Autor:
Emilia Kieckhöfer, Gisela G. Slaats, Lena K. Ebert, Marie-Christine Albert, Claudia Dafinger, Hamid Kashkar, Thomas Benzing, Bernhard Schermer
Publikováno v:
Cell Death Discovery. 8
Cilia are sensory organelles that project from the surface of almost all cells. Nephronophthisis (NPH) and NPH-related ciliopathies are degenerative genetic diseases caused by mutation of cilia-associated genes. These kidney disorders are characteriz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::706128a67428cee4ca28f8be2bc98838
https://doi.org/10.1038/s41420-022-01272-2
https://doi.org/10.1038/s41420-022-01272-2
Autor:
Vanessa L.S. LaPointe, Anika Schumacher, Matthew B. Baker, Gisela G. Slaats, Nadia J. T. Roumans, Floor A.A. Ruiter, Francis L. C. Morgan, Lorenzo Moroni
Publikováno v:
Advanced Science, 9(20):2200543. Wiley-VCH Verlag
Pluripotent stem cell-derived kidney organoids offer a promising solution to renal failure, yet current organoid protocols often lead to off-target cells and phenotypic alterations, preventing maturity. Here, various dynamic hydrogel architectures ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bf21a8524ab361db14f63b3833be4f5
https://doi.org/10.1002/advs.202200543
https://doi.org/10.1002/advs.202200543
Autor:
Gerard W. Dougherty, Victor L. Jensen, Jan Frederik Scheel, Katarzyna Szymanska, Uwe Wolfrum, Radek Szklarczyk, Miriam Schmidts, Julie Kennedy, Erwin van Wijk, Brunella Franco, Toby J. Gibson, Machteld M. Oud, Chunmei Li, Nils J. Lambacher, Erik de Vrieze, Grischa Toedt, Teunis J. P. van Dam, Karsten Boldt, Heymut Omran, Yves Texier, Rachel H. Giles, Ronald Roepman, Kirsten A. Wunderlich, Sylvia E. C. van Beersum, Oliver E. Blacque, Thanh-Minh T. Nguyen, Konstantinos Koutroumpas, Hannie Kremer, Nicola Horn, Martijn A. Huynen, Michel R. Leroux, Gabrielle Wheway, Rim Hjeij, Philip L. Beales, Gisela G. Slaats, Robert B. Russell, Robin van der Lee, François Képès, Yasmin Wissinger, Barbara Knapp, Dorus A. Mans, Suzanne Rix, Marius Ueffing, Colin A. Johnson, Stef J.F. Letteboer, Victor Hernandez-Hernandez, Qianhao Lu, Jeroen van Reeuwijk
Publikováno v:
PLoS ONE
PLoS One, 14
PLoS One. Public Library of Science
PloS one
PLOS ONE
PLOS ONE, 14(5):0216705. Public Library of Science
PLoS ONE, Vol 14, Iss 5, p e0216705 (2019)
PLoS One, 14, 5
PLoS One, 14
PLoS One. Public Library of Science
PloS one
PLOS ONE
PLOS ONE, 14(5):0216705. Public Library of Science
PLoS ONE, Vol 14, Iss 5, p e0216705 (2019)
PLoS One, 14, 5
The cilium is an essential organelle at the surface of mammalian cells whose dysfunction causes a wide range of genetic diseases collectively called ciliopathies. The current rate at which new ciliopathy genes are identified suggests that many ciliar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2772a70100890267dc91fbed9c4e654e
http://europepmc.org/articles/PMC6522010
http://europepmc.org/articles/PMC6522010
Autor:
Dimitri E P Muylaert, Gisela G. Slaats, Marie-José Goumans, Frederieke E Nieuweboer, Joost O. Fledderus, Marianne C. Verhaar, Beerend P. Hierck, Olivier G. de Jong
Publikováno v:
Tissue Engineering: Parts A, B, and C, 22(1), 58-67
Tissue engineering. Part C, Methods, 22(1), 58. Mary Ann Liebert Inc.
Tissue engineering. Part C, Methods, 22(1), 58. Mary Ann Liebert Inc.
Tissue-engineered grafts for cardiovascular structures experience biochemical stimuli and mechanical forces that influence tissue development after implantation such as the immunological response, oxidative stress, hemodynamic shear stress, and mecha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdcddae1ef198f48d51f3ca5ab66a98d
https://doi.org/10.1089/ten.teb.2015.0167
https://doi.org/10.1089/ten.teb.2015.0167
Autor:
Linda Blomberg, Martin Hoehne, Bernhard Schermer, Markus M. Rinschen, Thomas Benzing, Christine Kurschat, Fabian Braun, Laura E. Frech, Gisela G. Slaats
Publikováno v:
Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
Fabry disease is a lysosomal storage disorder resulting from impaired alpha-galactosidase A (α-Gal A) enzyme activity due to mutations in the GLA gene. Currently, powerful diagnostic tools and in vivo research models to study Fabry disease are missi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7196be3dcf263e390f58382c7c1422f
https://pubmed.ncbi.nlm.nih.gov/30038331
https://pubmed.ncbi.nlm.nih.gov/30038331
Autor:
Roman-Ulrich Müller, Martin Hoehne, Agnes B. Fogo, Sandra Habbig, Heike Göbel, Rainer W.J. Kaiser, Bernhard Schermer, Katrin Bohl, Katja Höpker, Malte P. Bartram, Manaswita Jain, Gisela G. Slaats, Thomas Benzing
Publikováno v:
Kidney international. 95(4)
Recent human genetic studies have suggested an intriguing link between ciliary signaling defects and altered DNA damage responses in nephronophthisis (NPH) and related ciliopathies. However, the molecular mechanism and the role of altered DNA damage
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e60f78b1d969d6ff879b8d93b681e98c
https://pubmed.ncbi.nlm.nih.gov/30770218
https://pubmed.ncbi.nlm.nih.gov/30770218
Autor:
Richard T. Pon, Ryan E. Lamont, Uwe Wolfrum, Robert A. Hegele, Dan Doherty, Fiona Stewart, Martin McKibbin, Jay Shendure, Grischa Toedt, Colin E. Willoughby, Jillian S. Parboosingh, Clem Donahue, Kirsten A. Wunderlich, Lijia Huang, Marius Ueffing, Hannah M. Mitchison, Nasrin Sorusch, Teunis J. P. van Dam, Zakia Abdelhamed, Kym M. Boycott, Francois P. Bernier, Mohammed A. Aldahmesh, Subaashini Natarajan, Bernard N. Chodirker, Carole Ober, Julie Higgins, Matthew Adams, Darren C. Tomlinson, Hilary E. Racher, Thanh Minh T. Nguyen, Ian G. Phelps, Andreas Giessl, Katarzyna Szymanska, Ewan E. Morrison, Albert E. Chudley, Fowzan S. Alkuraya, Panagiotis I. Sergouniotis, Patrick Frosk, Jacquelyn Bond, Miriam Schmidts, Susanne Roosing, Nicola Horn, Gabrielle Wheway, Sandra M. Bell, Carmel Toomes, Toby J. Gibson, Martijn A. Huynen, Philip L. Beales, Gisela G. Slaats, Julie Kennedy, Clare V. Logan, Oliver E. Blacque, Paul M. K. Gordon, Rachel H. Giles, Heymut Omran, Aizeddin A. Mhanni, A. James Barkovich, David A. Parry, A. Micheil Innes, Dorus A. Mans, Jeroen van Reeuwijk, Kristin Kessler, Louis Wolf, Shamsa Anazi, Evan A. Boyle, Karsten Boldt, Ronald Roepman, Joseph G. Gleeson, Andrew R. Webster, Selwa A. Al Hazzaa, Chris F. Inglehearn, Warren Herridge, Christian Thiel, Chandree L. Beaulieu, Colin A. Johnson, Stef J.F. Letteboer
Publikováno v:
Nature cell biology
Nature Cell Biology, 17, 8, pp. 1074-87
Nature Cell Biology, 17, 1074-87
Nature Cell Biology, 17(8), 1074. Nature Publishing Group
Nature Cell Biology, 17, 8, pp. 1074-87
Nature Cell Biology, 17, 1074-87
Nature Cell Biology, 17(8), 1074. Nature Publishing Group
Item does not contain fulltext Defects in primary cilium biogenesis underlie the ciliopathies, a growing group of genetic disorders. We describe a whole-genome siRNA-based reverse genetics screen for defects in biogenesis and/or maintenance of the pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08f0b712fcab169cef607b95c1a1e715
https://doi.org/10.1038/ncb3201
https://doi.org/10.1038/ncb3201