Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Gisela D. Cymes"'
Publikováno v:
Proc Natl Acad Sci U S A
Although it has long been proposed that membrane proteins may contain tightly bound lipids, their identity, the structure of their binding sites, and their functional and structural relevance have remained elusive. To some extent, this is because tig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ca805e8b6b9c0e81f17338674df0bdc
https://doi.org/10.1073/pnas.2100164118
https://doi.org/10.1073/pnas.2100164118
Autor:
Claudio Grosman, Gisela D. Cymes
Publikováno v:
Proc Natl Acad Sci U S A
One of the most fundamental questions in the field of Cys-loop receptors (pentameric ligand-gated ion channels, pLGICs) is how the affinity for neurotransmitters and the conductive/nonconductive state of the transmembrane pore are correlated despite
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e826d22a715c7e1115fed285ca302889
https://pubmed.ncbi.nlm.nih.gov/33785596
https://pubmed.ncbi.nlm.nih.gov/33785596
Autor:
Emad Tajkhorshid, Claudio Grosman, Zhiyu Zhao, Gisela D. Cymes, Zhening Zhang, Pramod Kumar, Yuhang Wang
Publikováno v:
Proc Natl Acad Sci U S A
The lipid dependence of the nicotinic acetylcholine receptor from the Torpedo electric organ has long been recognized, and one of the most consistent experimental observations is that, when reconstituted in membranes formed by zwitterionic phospholip
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a6e1a81d991b8a3c865e7ecd4f76fdb
https://pubmed.ncbi.nlm.nih.gov/31911476
https://pubmed.ncbi.nlm.nih.gov/31911476
Publikováno v:
The Journal of General Physiology
Members of the pentameric ligand-gated ion channel family have been crystallized in different conformations, including one in which the transmembrane pore is surprisingly wide. Gonzalez-Gutierrez et al. show that the open-channel conformation of anim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9384d8182c227b5039a758e63d5b29c1
https://doi.org/10.1085/jgp.201711803
https://doi.org/10.1085/jgp.201711803
Autor:
Gisela D. Cymes, Claudio Grosman
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 113(45)
Among neurotransmitter-gated ion channels, the superfamily of pentameric ligand-gated ion channels (pLGICs) is unique in that its members display opposite permeant-ion charge selectivities despite sharing the same structural fold. Although much effor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28e8dbcd30944e282e4245f7a951aecc
https://pubmed.ncbi.nlm.nih.gov/27791102
https://pubmed.ncbi.nlm.nih.gov/27791102
Autor:
Claudio Grosman, Gisela D. Cymes
Publikováno v:
Nature chemical biology
In ion channels, “rings” of ionized side chains that decorate the walls of the permeation pathway often lower the energetic barrier to ion conduction. Using single-channel electrophysiological recordings, we studied the poorly understood ring of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49e1a94afcaac0534dc13f4cd7b128e5
https://doi.org/10.1038/nchembio.1092
https://doi.org/10.1038/nchembio.1092
Autor:
Claudio Grosman, Gisela D. Cymes
Publikováno v:
Proteins: Structure, Function, and Bioinformatics. 79:3485-3493
As a step toward gaining a better understanding of the physicochemical bases of pK(a)-value shifts in ion channels, we have previously proposed a method for estimating the proton affinities of systematically engineered ionizable side chains from the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3376420b99ea3c67ebcdcf987525d73
https://doi.org/10.1002/prot.23087
https://doi.org/10.1002/prot.23087
Autor:
Claudio Grosman, Gisela D. Cymes
Publikováno v:
Nature
Among ion channels, only the nicotinic-receptor superfamily has evolved to generate both cation- and anion-selective members. Although other, structurally unrelated, neurotransmitter-gated cation channels exist, no other type of neurotransmitter-gate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ff7c8219aa0e68c151593c114cf4abd
http://europepmc.org/articles/PMC3121909
http://europepmc.org/articles/PMC3121909
Publikováno v:
The Journal of General Physiology
The slow-channel congenital myasthenic syndrome (SCCMS) is a disorder of the neuromuscular junction caused by gain-of-function mutations to the muscle nicotinic acetylcholine (ACh) receptor (AChR). Although it is clear that the slower deactivation ti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7e9b043639ea363d93fe59fa2a1ab82
https://doi.org/10.1085/jgp.200810089
https://doi.org/10.1085/jgp.200810089
Autor:
Gisela D. Cymes, Carlota Wolfenstein-Todel, Juan J. Caridad, Fabián M. Atlasovich, M. Mercedes Iglesias
Publikováno v:
International Journal of Peptide and Protein Research. 44:31-35
The reactivity of arginine residues in ovine prolactin was studied by reaction with 1,2-cyclohexanedione. Kinetic analysis of the data showed a good fit with two simultaneous pseudo-first-order equations with apparent velocity constants of 0.28 and 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2441d1611c7ec6fbc766137fca787773
https://doi.org/10.1111/j.1399-3011.1994.tb00401.x
https://doi.org/10.1111/j.1399-3011.1994.tb00401.x