Zobrazeno 1 - 10
of 84
pro vyhledávání: '"Gisa, Gerold"'
Autor:
Kris Gerard Alvarez, Lisa Goral, Abdulhadi Suwandi, Lisa Lasswitz, Francisco J. Zapatero-Belinchón, Katrin Ehrhardt, Kumar Nagarathinam, Katrin Künnemann, Thomas Krey, Agnes Wiedemann, Gisa Gerold, Guntram A. Grassl
Publikováno v:
Virulence, Vol 15, Iss 1 (2024)
Human CD81 and CD9 are members of the tetraspanin family of proteins characterized by a canonical structure of four transmembrane domains and two extracellular loop domains. Tetraspanins are known as molecular facilitators, which assemble and organiz
Externí odkaz:
https://doaj.org/article/9dea300125274fc9b995bc95c8ce982c
Autor:
Dandan Li, Melanie Bühler, Sandra Runft, Gisa Gerold, Katarzyna Marek, Wolfgang Baumgärtner, Till Strowig, Ingo Gerhauser
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract Theiler's murine encephalomyelitis virus (TMEV) induces an acute polioencephalomyelitis and a chronic demyelinating leukomyelitis in SJL mice. C57BL/6 (B6) mice generally do not develop TMEV-induced demyelinating disease (TMEV-IDD) due to vi
Externí odkaz:
https://doaj.org/article/b1ad3b6cfc2849ddb305076e35c7e1cf
Autor:
Alina Matthaei, Sebastian Joecks, Annika Frauenstein, Janina Bruening, Dorothea Bankwitz, Martina Friesland, Gisa Gerold, Gabrielle Vieyres, Lars Kaderali, Felix Meissner, Thomas Pietschmann
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 2 (2024)
ABSTRACTAssembly of infectious hepatitis C virus (HCV) particles requires multiple cellular proteins including for instance apolipoprotein E (ApoE). To describe these protein-protein interactions, we performed an affinity purification mass spectromet
Externí odkaz:
https://doaj.org/article/376bdc7a189e4ffe9567f56ee0bc03d1
Autor:
Belén Carriquí-Madroñal, Julie Sheldon, Mara Duven, Cora Stegmann, Karsten Cirksena, Emanuel Wyler, Francisco J Zapatero-Belinchón, Florian W R Vondran, Gisa Gerold
Publikováno v:
PLoS Pathogens, Vol 19, Iss 11, p e1011759 (2023)
Hepatitis C virus (HCV) exploits the four entry factors CD81, scavenger receptor class B type I (SR-BI, also known as SCARB1), occludin, and claudin-1 as well as the co-factor epidermal growth factor receptor (EGFR) to infect human hepatocytes. Here,
Externí odkaz:
https://doaj.org/article/76780a28da144d5ead51c0d30a884af0
Autor:
Baxolele Mhlekude, Dylan Postmus, Saskia Stenzel, January Weiner, Jenny Jansen, Francisco J Zapatero-Belinchón, Ruth Olmer, Anja Richter, Julian Heinze, Nicolas Heinemann, Barbara Mühlemann, Simon Schroeder, Terry C Jones, Marcel A Müller, Christian Drosten, Andreas Pich, Volker Thiel, Ulrich Martin, Daniela Niemeyer, Gisa Gerold, Dieter Beule, Christine Goffinet
Publikováno v:
PLoS Pathogens, Vol 19, Iss 9, p e1011657 (2023)
Inhibitors of bromodomain and extra-terminal proteins (iBETs), including JQ-1, have been suggested as potential prophylactics against SARS-CoV-2 infection. However, molecular mechanisms underlying JQ-1-mediated antiviral activity and its susceptibili
Externí odkaz:
https://doaj.org/article/68f2a8478fe7484fafc679780534d4ce
Publikováno v:
BMC Bioinformatics, Vol 22, Iss 1, Pp 1-24 (2021)
Abstract Background Viral infections are causing significant morbidity and mortality worldwide. Understanding the interaction patterns between a particular virus and human proteins plays a crucial role in unveiling the underlying mechanism of viral i
Externí odkaz:
https://doaj.org/article/7f0946352b384d449aa7911036baabb1
Autor:
Katarzyna Marek, Federico Armando, Thanaporn Asawapattanakul, Vanessa Maria Nippold, Philippe Plattet, Gisa Gerold, Wolfgang Baumgärtner, Christina Puff
Publikováno v:
Pathogens, Vol 12, Iss 7, p 877 (2023)
The immune response plays a key role in the treatment of malignant tumors. One important molecule promoting humoral and cellular immunity is granulocyte–macrophage colony-stimulating factor (GM-CSF). Numerous successful trials have led to the appro
Externí odkaz:
https://doaj.org/article/926711eb77a641aaaaf86c6e63b5fdcc
Autor:
Lisa Lasswitz, Francisco J. Zapatero-Belinchón, Rebecca Moeller, Kirsten Hülskötter, Timothée Laurent, Lars-Anders Carlson, Christine Goffinet, Graham Simmons, Wolfgang Baumgärtner, Gisa Gerold
Publikováno v:
mBio, Vol 13, Iss 3 (2022)
ABSTRACT Chikungunya virus (CHIKV) is an arthritogenic reemerging virus replicating in plasma membrane-derived compartments termed “spherules.” Here, we identify the human transmembrane protein CD81 as host factor required for CHIKV replication.
Externí odkaz:
https://doaj.org/article/d93b517ce2894b59bbb422aa8e6efc0e
Autor:
Muhammad Nasir Hayat Malik, Syed Fakhar-ul-Hassnain Waqas, Jana Zeitvogel, Jingyuan Cheng, Robert Geffers, Zeinab Abu-Elbaha Gouda, Ahmed Mahrous Elsaman, Ahmed R. Radwan, Matthias Schefzyk, Peter Braubach, Bernd Auber, Ruth Olmer, Mathias Müsken, Lennart M. Roesner, Gisa Gerold, Sven Schuchardt, Sylvia Merkert, Ulrich Martin, Felix Meissner, Thomas Werfel, Frank Pessler
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 3 (2022)
Ulcerating skin lesions are manifestations of human ISG15 deficiency, a type I interferonopathy. However, chronic inflammation may not be their exclusive cause. We describe two siblings with recurrent skin ulcers that healed with scar formation upon
Externí odkaz:
https://doaj.org/article/954f97e3aee74d59a2deee752c511caf
Autor:
Francisco J. Zapatero-Belinchón, Rebecca Moeller, Lisa Lasswitz, Marco van Ham, Miriam Becker, Graham Brogden, Ebba Rosendal, Wenjie Bi, Belén Carriquí-Madroñal, Koushikul Islam, Annasara Lenman, Antonia P. Gunesch, Jared Kirui, Thomas Pietschmann, Anna K. Överby, Lothar Jänsch, Gisa Gerold
Publikováno v:
iScience, Vol 24, Iss 12, Pp 103469- (2021)
Summary: Clinical data of patients suffering from COVID-19 indicates that statin therapy, used to treat hypercholesterolemia, is associated with a better disease outcome. Whether statins directly affect virus replication or influence the clinical out
Externí odkaz:
https://doaj.org/article/34bc37bb80fe4e8db30733cdbb761e1b