Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Gisèle Guilbaud"'
Publikováno v:
Neuropharmacology. 39:1589-1595
We have previously shown that rats with a painful peripheral neuropathy develop dependence without tolerance after repetitive doses [3 mg/kg subcutaneously (s.c.)] of morphine. After injections of a higher dose (10 mg/kg s.c.) the animals develop tol
Publikováno v:
Anesthesiology. 92:786-794
Background Tolerance to the analgesic effect of morphine complicates the management of chronic pain states. The authors studied the ability of the glycine/N-methyl-D-aspartate receptor antagonist (+)-HA966 to modify morphine tolerance in a rat model
Publikováno v:
Pain. 83:509-516
The development of tolerance following repeated doses of morphine hinders the treatment of clinical pain. We have previously shown that morphine tolerance develops in neuropathic rats without cross-tolerance to a systemic kappa-opioid agonist; in the
Publikováno v:
Pain. 79:281-290
Trigeminal neuralgia is an example of an extreme form of neuropathic pain and continues to be a real therapeutic challenge. Although the pathophysiology of the disorder is uncertain, vascular compression of the trigeminal root resulting in damage to
Publikováno v:
British Journal of Pharmacology. 125:1641-1650
1. We evaluated the ability of the functional antagonist at the glycine site of the N-methyl-D-aspartate (NMDA) receptor complex, (+)-(1-Hydroxy-3-aminopyrrolodine-2-one) ((+)-HA966), to modulate the antinociceptive action of systemic morphine in a r
Publikováno v:
Brain Research. 794:19-27
Two hindpaw injections of carrageenin were performed 7 days apart and the time-course of the vocalization thresholds to pressure (VTPP) of all the 4 paws of the rat were measured after both injections. The first injection of carrageenin induced an in
Publikováno v:
European Journal of Pharmacology. 325:155-164
The ability of the selective cholecystokinin(B) (CCK(B)) receptor antagonist L-365,260 (0.2 mg/kg s.c.) to modulate the antinociceptive action of relatively low doses of systemic morphine (0.1, 0.3 and 1.0 mg/kg i.v.) was evaluated using a well estab
Publikováno v:
Brain Research. 695:92-95
This study examined responses of 35 neurons in the caudal intralaminar (IL) thalamic nuclei in 12 adult female virgin rats to mechanical stimulation of the skin (brush, pressure, pinch) and to 4 different visceral stimuli (noxious distension of the u
Autor:
Raymonde Hässig, G. Filliatreau, Nadine Attal, Luigi DiGiamberardino, Gisèle Guilbaud, J. A. Desmeules
Publikováno v:
Pain, Vol. 59, No 3 (1994) pp. 405-413
Changes in the axonal transport of acetylcholinesterase (AChE) were studied in the painful mononeuropathy induced by setting 4 loose ligatures around the right sciatic nerve of the rat. Since changes in the axonal transport of AChE can be used to ass
Publikováno v:
European Journal of Pharmacology. 264:61-67
The antinociceptive effect of i.v. kelatorphan (2.5, 5, 10 and 15 mg/kg), a mixed inhibitor of enkephalin degrading enzymes, was studied in a rat model of peripheral unilateral mononeuropathy (chronic constriction of the common sciatic nerve). Kelato