Zobrazeno 1 - 10
of 471
pro vyhledávání: '"Girolamo, Calo"'
Autor:
Justyna Piekielna-Ciesielska, Davide Malfacini, Francine Medjiofack Djeujo, Chantal Marconato, Karol Wtorek, Girolamo Calo’, Anna Janecka
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
The mu opioid receptor agonists are the most efficacious pain controlling agents but their use is accompanied by severe side effects. More recent developments indicate that some ligands can differentially activate receptor downstream pathways, possib
Externí odkaz:
https://doaj.org/article/f4a1f2d1899345fa81adb58a5b44cd70
Autor:
Despina Giakomidi, Sonja Khemiri, Wadhah Mahbuba, David G. McVey, Fatin Al-Janabi, Remo Guerrini, Girolamo Calo, Shu Ye, David G. Lambert
Publikováno v:
BJA Open, Vol 4, Iss , Pp 100110- (2022)
Background: Opioid receptors are naloxone-sensitive (MOP [mu: μ], DOP [delta: δ], and KOP [kappa: κ]) and naloxone-insensitive Nociceptin/Orphanin FQ (N/OFQ) peptide receptor (NOP). Clinically, most opioid analgesics target MOP. Angiogenesis is th
Externí odkaz:
https://doaj.org/article/1dee7627c7d04f38879e5822c85bdbf7
Autor:
Chiara Sturaro, Davide Malfacini, Michela Argentieri, Francine M. Djeujo, Erika Marzola, Valentina Albanese, Chiara Ruzza, Remo Guerrini, Girolamo Calo’, Paola Molinari
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
The present study investigated the in vitro pharmacology of the human kappa opioid receptor using multiple assays, including calcium mobilization in cells expressing chimeric G proteins, the dynamic mass redistribution (DMR) label-free assay, and a b
Externí odkaz:
https://doaj.org/article/25d09c7909904b40bb5b128ded4d84b3
Autor:
Ming Tatt Lee, Yu-Ting Chiu, Yu-Chun Chiu, Chia Chun Hor, Hsin-Jung Lee, Remo Guerrini, Girolamo Calo, Lih-Chu Chiou
Publikováno v:
Journal of Biomedical Science, Vol 27, Iss 1, Pp 1-15 (2020)
Abstract Background Stress-induced analgesia (SIA) is an evolutionarily conserved phenomenon during stress. Neuropeptide S (NPS), orexins, substance P, glutamate and endocannabinoids are known to be involved in stress and/or SIA, however their causal
Externí odkaz:
https://doaj.org/article/53f537b86a584716bdf814fb935a0b18
Autor:
Mark F. Bird, Barbara Gallacher-Horley, John McDonald, David G. McVey, Fatin Al-Janabi, Remo Guerrini, Girolamo Calo, Shu Ye, Jonathan P. Thompson, David G. Lambert
Publikováno v:
PLoS ONE, Vol 17, Iss 9 (2022)
Sepsis is a dysregulated host response to infection that can cause widespread effects on other organs including cardiovascular depression, hypotension and organ failure. The receptor for Nociceptin/Orphanin FQ (N/OFQ), NOP is expressed on immune cell
Externí odkaz:
https://doaj.org/article/9c6ee19a704e489aa1cb76aea8f0b547
Autor:
Despina Giakomidi, Mark F Bird, John McDonald, Erika Marzola, Remo Guerrini, Serena Chanoch, Nidhuna Sabu, Barbara Horley, Girolamo Calo, David G Lambert
Publikováno v:
PLoS ONE, Vol 16, Iss 4, p e0250011 (2021)
The μ-opioid peptide (MOP) receptor is a member of the opioid receptor family and an important clinical target for analgesia. Measuring MOP receptor location and tracking its turnover traditionally used radiolabels or antibodies with attendant probl
Externí odkaz:
https://doaj.org/article/3d721b91f5e747c9a50308c7c9d303cf
Autor:
Victor A.D. Holanda, Matheus C. Oliveira, Edilson D. Da Silva Junior, Girolamo Calo', Chiara Ruzza, Elaine C. Gavioli
Publikováno v:
Neurobiology of Stress, Vol 13, Iss , Pp 100255- (2020)
The role of stress in the etiology of depression has been largely reported. In this line, exogenous glucocorticoids are employed to mimic the influence of stress on the development of depression. The N/OFQ-NOP receptor system has been implicated in t
Externí odkaz:
https://doaj.org/article/f8e2b76afd274ffe8852519771463275
Autor:
Anna Fantinati, Sara Bianco, Remo Guerrini, Severo Salvadori, Salvatore Pacifico, Maria Camilla Cerlesi, Girolamo Calo, Claudio Trapella
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-7 (2017)
Abstract A diastereoselective synthesis of the title compound as a single E diastereomer has been efficiently accomplished by assembling the featured pyrano-indole scaffold of the spiro[cyclohexane-dihydropyrano[3,4-b]-indole]-amine framework through
Externí odkaz:
https://doaj.org/article/f9793336055c4632b76511f6e3164571
Autor:
Mark F. Bird, Christopher P. Hebbes, Anushuya Tamang, Jonathon Mark Willets, Jonathan P. Thompson, Remo Guerrini, Girolamo Calo, David G. Lambert
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a316f1aec76a8fa1c191adf9c25cbd62
https://hdl.handle.net/11577/3479489
https://hdl.handle.net/11577/3479489
Autor:
Davide Malfacini, Katharina Simon, Claudio Trapella, Remo Guerrini, Nurulain T Zaveri, Evi Kostenis, Girolamo Calo'
Publikováno v:
PLoS ONE, Vol 13, Iss 8, p e0203021 (2018)
The Nociceptin/Orphanin FQ (N/OFQ) peptide NOP receptor is coupled to pertussis toxin (PTX)-sensitive G proteins (Gi/o) whose activation leads to the inhibition of both cAMP production and calcium channel activity, and to the stimulation of potassium
Externí odkaz:
https://doaj.org/article/be7ca1bc72664702915490507d966f61