Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Girma M. Woldemichael"'
Autor:
Yong Yean Kim, Berkley E. Gryder, Ranuka Sinniah, Megan L. Peach, Jack F. Shern, Abdalla Abdelmaksoud, Silvia Pomella, Girma M. Woldemichael, Benjamin Z. Stanton, David Milewski, Joseph J. Barchi, John S. Schneekloth, Raj Chari, Joshua T. Kowalczyk, Shilpa R. Shenoy, Jason R. Evans, Young K. Song, Chaoyu Wang, Xinyu Wen, Hsien-Chao Chou, Vineela Gangalapudi, Dominic Esposito, Jane Jones, Lauren Procter, Maura O’Neill, Lisa M. Jenkins, Nadya I. Tarasova, Jun S. Wei, James B. McMahon, Barry R. O’Keefe, Robert G. Hawley, Javed Khan
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Fusion-positive rhabdomyosarcoma (FP-RMS) is an aggressive pediatric sarcoma driven primarily by the PAX3-FOXO1 fusion oncogene, for which therapies targeting PAX3-FOXO1 are lacking. Here, we screen 62,643 compounds using an engineered cell
Externí odkaz:
https://doaj.org/article/62fcc583cb83489ca474d4e078b73633
Autor:
Berkley E. Gryder, Lei Wu, Girma M. Woldemichael, Silvia Pomella, Taylor R. Quinn, Paul M. C. Park, Abigail Cleveland, Benjamin Z. Stanton, Young Song, Rossella Rota, Olaf Wiest, Marielle E. Yohe, Jack F. Shern, Jun Qi, Javed Khan
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Core regulatory transcription factors are usually regulated by cell-type specific super enhancers (SEs). Here, the authors screen for chemical probes able to distinguish between SE-driven and promoter-driven transcription and find that histone deacet
Externí odkaz:
https://doaj.org/article/742c055d88f34a9a94fff834255a1649
Autor:
Girma M. Woldemichael, Thomas J. Turbyville, James R. Vasselli, W. Marston Linehan, James B. McMahon
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 14, Iss 8, Pp 771-777 (2012)
Verrucarin A (VA) is a small molecule derived from the fungal plant pathogen Myrothecium verrucaria and was identified as a selective inhibitor of clear cell renal cell carcinoma (CCRCC) cell proliferation in a high-throughput screen of a library of
Externí odkaz:
https://doaj.org/article/672c2e8f8c1241688e9f7c61c59ed12a
Autor:
Patrick J. Grohar, Francisco Morís, Lee J. Helman, Javier González-Sabín, Luz-Elena Núñez, Mary E. Winn, Zachary B. Madaj, Lisa Turner, Malcolm Smith, Min Kang, Stephen L. Lessnick, Savita Sankar, Min He, Girma M. Woldemichael, Meti Gebregiorgis, Laura Segars, Susan Kitchen-Goosen, Christopher G. Kidd, Nichole Maloney, Christy L. Osgood
Purpose: The goal of this study was to identify second-generation mithramycin analogues that better target the EWS-FLI1 transcription factor for Ewing sarcoma. We previously established mithramycin as an EWS-FLI1 inhibitor, but the compound's toxicit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d0749f76a543249a5b3ef28f63aea13
https://doi.org/10.1158/1078-0432.c.6523083.v1
https://doi.org/10.1158/1078-0432.c.6523083.v1
Autor:
Patrick J. Grohar, Francisco Morís, Lee J. Helman, Javier González-Sabín, Luz-Elena Núñez, Mary E. Winn, Zachary B. Madaj, Lisa Turner, Malcolm Smith, Min Kang, Stephen L. Lessnick, Savita Sankar, Min He, Girma M. Woldemichael, Meti Gebregiorgis, Laura Segars, Susan Kitchen-Goosen, Christopher G. Kidd, Nichole Maloney, Christy L. Osgood
Table S1, PCR primers used in gene signature panel. Table S2, Evidence for selection of each gene as an EWS-FLI1 target. S3A Mean fold change in expression of NR0B1 as a function of GAPDH (2Î"Î"CT) following treatment with MMA or EC-8105. Data is t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41af203bf3e40e5edb0bf0c619f46fdf
https://doi.org/10.1158/1078-0432.22455681
https://doi.org/10.1158/1078-0432.22455681
Supplementary Methods, Figures 1-5 from Carminomycin I Is an Apoptosis Inducer That Targets the Golgi Complex in Clear Cell Renal Carcinoma Cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::366b258a0b354f56406daf703c56b9c7
https://doi.org/10.1158/0008-5472.22387065.v1
https://doi.org/10.1158/0008-5472.22387065.v1
Autor:
Wei Jiang, Xiangrong Tian, Dongdong Wang, Heidi R. Bokesch, Cheryl L. Thomas, Girma M. Woldemichael, Berkley E. Gryder, Jun S. Wei, Young K. Song, Hsien-Chao Chou, Javed Khan, Barry R. O’Keefe, Kirk R. Gustafson
Publikováno v:
Journal of Natural Products. 85:1419-1427
Autor:
Wei Jiang, Kirk R. Gustafson, Javed Khan, Chang-Kwon Kim, Barry R. O'Keefe, Heidi R. Bokesch, Girma M. Woldemichael, John A. Beutler, John F. Shern, Dongdong Wang, Berkley E. Gryder
Publikováno v:
Org Lett
Neopetrothiazide (1), a pentacyclic isoquinoline quinone, was isolated from a Neopetrosia sp. sponge. The structure elucidation was facilitated by utilizing long-range heteronuclear single quantum multiple bond correlation (LR-HSQMBC) and heteronucle
Publikováno v:
Structure
ETS family transcription factors of ERG and FLI1 play a key role in oncogenesis of prostate cancer and Ewing sarcoma by binding regulatory DNA sites and interfering with function of other factors. Mithramycin (MTM) is an anti-cancer, DNA binding natu
Autor:
Abigail Cleveland, Marielle E. Yohe, Jack F. Shern, Lei Wu, Rossella Rota, Paul M.C. Park, Berkley E. Gryder, Olaf Wiest, Jun Qi, Silvia Pomella, Javed Khan, Taylor R. Quinn, Girma M. Woldemichael, Benjamin Z. Stanton, Young Min Song
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Nature Communications
Nature Communications
Identity determining transcription factors (TFs), or core regulatory (CR) TFs, are governed by cell-type specific super enhancers (SEs). Drugs to selectively inhibit CR circuitry are of high interest for cancer treatment. In alveolar rhabdomyosarcoma