Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Girish V. Putcha"'
Publikováno v:
Current Genetic Medicine Reports. 3:127-136
Non-invasive prenatal screening (NIPS) for fetal aneuploidy detection using cell-free fetal DNA from maternal circulation has been rapidly adopted for use in high-risk pregnancies since its inception in 2011. While most published NIPS studies are wri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8a0e1f15c59f84658f5da1c1a892f129
https://doi.org/10.1007/s40142-015-0072-z
https://doi.org/10.1007/s40142-015-0072-z
Autor:
Eunice Chang, Thierry Jahan, Girish V. Putcha, Shane P. Dormady, Michael S. Broder, Alison H. DeCristofaro, Robert H. Dumanois, Paul Billings
Publikováno v:
International Journal of Clinical Oncology. 20:59-69
Five-year survival in early–stage, non-squamous, non-small-cell lung cancer (NSCLC) remains poor compared with other solid tumors, even after complete resection. Post-operative management depends on prognostic staging to identify individuals at hig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63c71fffbc3ea0c9768ee1295d357abd
https://doi.org/10.1007/s10147-014-0700-8
https://doi.org/10.1007/s10147-014-0700-8
Autor:
Maimoona A. Zariwala, Richard J. Wenstrup, Girish V. Putcha, Kasinathan Muralidharan, Ishrag Khababa, Soma Das, Bai-Lin Wu, Stacey Withrow, Nancy Carson, Fred Schaefer, Jessica K. Booker, Karen E. Weck, Rong Mao, Michelle A. Springer, Iris M. Otani, Melissa A Dempsey, Margaret A. Kenna, Marcy L. Hoffmann, John H. Greinwald, Bassem A. Bejjani, Linda Jo Bone Jeng, John C. Carey, Stacey L. Bleoo, Elaine B. Spector, Iris Schrijver, Margaret Lilley, Heidi L. Rehm, William K. Seltzer, Julie M. Gastier-Foster
Publikováno v:
Genetics in Medicine. 9:413-426
Purpose: The aim of the study was to determine the actual GJB2 and GJB6 mutation frequencies in North America after several years of generalized testing for autosomal recessive nonsyndromic sensorineural hearing loss to help guide diagnostic testing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77164420c9884806ce45c835c3b2b0d3
https://doi.org/10.1097/gim.0b013e3180a03276
https://doi.org/10.1097/gim.0b013e3180a03276
Autor:
Girish V. Putcha, Kim Clark, Shari Alix, Stephan Frank, Maroney Anna, Cagri G. Besirli, Eugene M. Johnson, Siyuan Le, Boyang Chu, Richard J. Youle, Art LaMarche
Publikováno v:
Neuron. 38:899-914
Trophic factor deprivation (TFD) activates c-Jun N-terminal kinases (JNKs), culminating in coordinate AP1-dependent transactivation of the BH3-only BCL-2 proteins BIM EL and HRK, which in turn are critical for BAX-dependent cytochrome c release, casp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd78ee23c7d8acc1b87398e075bfcf62
https://doi.org/10.1016/s0896-6273(03)00355-6
https://doi.org/10.1016/s0896-6273(03)00355-6
Autor:
Charles A. Harris, Rachael M. Easton, Eugene M. Johnson, Craig B. Thompson, Girish V. Putcha, Krista L. Moulder
Publikováno v:
The Journal of Cell Biology
Trophic factor deprivation (TFD)-induced apoptosis in sympathetic neurons requires macromolecular synthesis–dependent BAX translocation, cytochrome c (cyt c) release, and caspase activation. Here, we report the contributions of other intrinsic and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4318498bc69c449914bbb85cd5606757
http://europepmc.org/articles/PMC2173286
http://europepmc.org/articles/PMC2173286
Granzyme B can cause mitochondrial depolarization and cell death in the absence of BID, BAX, and BAK
Publikováno v:
Proceedings of the National Academy of Sciences. 98:14985-14990
Granzyme B (GzmB) is a serine protease that is used by activated cytotoxic T lymphocytes to induce target cell apoptosis. Although GzmB directly cleaves the Bcl2 family member BID on target cell entry,Bid-deficient (andBax, Bakdoubly deficient) cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17cb5c85d1e9ad6532a736d2ac19e45f
https://doi.org/10.1073/pnas.261581498
https://doi.org/10.1073/pnas.261581498
Autor:
Andreas Strasser, Judith P. Golden, Philippe Bouillet, Jerry Adams, Eugene M. Johnson, Girish V. Putcha, Krista L. Moulder
Publikováno v:
Europe PubMed Central
Sympathetic neuronal death induced by nerve growth factor (NGF) deprivation requires the macromolecular synthesis–dependent translocation of BAX from the cytosol to mitochondria and its subsequent integration into the mitochondrial outer membrane,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::216a86411d329146d1e323ba7653da57
https://doi.org/10.1016/s0896-6273(01)00238-0
https://doi.org/10.1016/s0896-6273(01)00238-0
Publikováno v:
The Journal of Cell Biology
During development, neurons are acutely dependent on target-derived trophic factors for survival. This dependence on trophic support decreases dramatically with maturation in several neuronal populations, including sympathetic neurons. Analyses of ne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74c38e7ab554b4bc8f5a30ebbded7f8f
https://doi.org/10.1083/jcb.149.5.1011
https://doi.org/10.1083/jcb.149.5.1011
Publikováno v:
The Journal of Neuroscience. 19:7476-7485
Members of the BCL-2 family of proteins either promote or repress programmed cell death. Here we report that neonatal sympathetic neurons undergoing apoptosis after nerve growth factor (NGF) deprivation exhibited a protein synthesis-dependent, caspas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02f6bccc2c58da2d7f3f90575c61823f
https://doi.org/10.1523/jneurosci.19-17-07476.1999
https://doi.org/10.1523/jneurosci.19-17-07476.1999
Autor:
Eric K. Hoffman, Andrew G. Reaume, Kevin K. Ohlemiller, James S. Wright, Richard Salvi, Sandra L. McFadden, Dalian Ding, Dorothy G. Flood, Richard W. Scott, Girish V. Putcha
Publikováno v:
Audiology and Neurotology. 4:237-246
Reactive oxygen species (ROS) such as superoxide, peroxide and hydroxyl radicals are generated during normal cellular metabolism and are increased in acute injury and in many chronic disease states. When their production is inadequately regulated, RO
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0fcb69605c28ebc7982f3af75613cdfc
https://doi.org/10.1159/000013847
https://doi.org/10.1159/000013847