Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Girish S, Gudi"'
Autor:
Blandine Pouleau, Carole Estoppey, Perrine Suere, Emilie Nallet, Amélie Laurendon, Thierry Monney, Daniela Pais Ferreira, Adam Drake, Laura Carretero-Iglesia, Julie Macoin, Jeremy Berret, Maria Pihlgren, Marie-Agnes Doucey, Girish S Gudi, Vinu Menon, Venkatesha Udupa, Abhishek Maiti, Gautam Borthakur, Ankita Srivastava, Stanislas Blein, Lamine Mbow, Thomas Matthes, Zeynep Kaya, Claire M Edwards, James R Edwards, Emmanuelle Menoret, Charlotte Kervoelen, Catherine Pellat-Deceunynck, Philippe Moreau, Eugene Alexander Zhukovsky, Mario Perro, Myriam Chimen
Publikováno v:
Blood Journal.
Whilst treatment of multiple myeloma (MM) with daratumumab significantly extend patient lifespan, resistance to therapy is inevitable. ISB 1342 was designed to target MM cells from patients with relapsed/refractory MM (r/rMM) displaying lower sensiti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a4fe89bd3308d6688a193e59e795c418
https://doi.org/10.1182/blood.2022019451
https://doi.org/10.1182/blood.2022019451
Autor:
Satyawan Jadhav, Sanjay Deshmukh, Siddharth Mhatre, Abhay Kulkarni, Shital Tondlekar, Samitabh Chakraborti, Nagarajan Muthukaman, Macchindra Tambe, Dnyandeo Pisal, Vikram Mansingh Bhosale, Neelam Sarode, Daisy Manish Shah, Mahamad Yunnus A. Mahat, Girish S. Gudi, Neelima Khairatkar-Joshi, Laxmikant Atmaram Gharat
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 28:3766-3773
Endogenous nitrosothiols (SNOs) including S-nitrosoglutathione (GSNO) serve as reservoir for bioavailable nitric oxide (NO) and mediate NO-based signaling, inflammatory status and smooth muscle function in the lung. GSNOR inhibition increases pulmona
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e69f3548323ec6b3cb510c32ec44b9f3
https://doi.org/10.1016/j.bmcl.2018.10.012
https://doi.org/10.1016/j.bmcl.2018.10.012
Autor:
Vidya Ganapati Kattige, Srinivasa Honnegowda, Sanjay Deshmukh, Laxmikant Atmaram Gharat, Abhay Kulkarni, Neelam Sarode, Pooja Sawant, Shital Tondlekar, Neelima Khairatkar-Joshi, Vikas Karande, Dnyandeo Pisal, Satyawan Jadhav, Macchindra Tambe, Nagarajan Muthukaman, Mahamadhanif S. Shaikh, Ramchandra R. Sangana, Monali Pisat, Girish S. Gudi, Dayanidhi Behera
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 27:5131-5138
This letter describes the synthesis and biological evaluation of furan and dihydrofuran-fused tricyclic benzo[d]imidazole derivatives as novel mPGES-1 inhibitors, capable of inhibiting an increased PGE2 production in the disease state. Structure-acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c711ec94b372ec3592b14b193fefd59c
https://doi.org/10.1016/j.bmcl.2017.10.062
https://doi.org/10.1016/j.bmcl.2017.10.062
Autor:
Srinivasa Honnegowda, Shital Tondlekar, Dnyandeo Pisal, Abhay Kulkarni, Dayanidhi Behera, Girish S. Gudi, Laxmikant Atmaram Gharat, Macchindra Tambe, Nagarajan Muthukaman, Sanjay Deshmukh, Satyawan Jadhav, Jitendra Maganbhai Gajera, Neelam Sarode, Mahamadhanif S. Shaikh, Vikas Karande, Lakshminarayana Narayana, Vidya Ganapati Kattige, Neelima Khairatkar-Joshi
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 27:2594-2601
A series of substituted tricyclic 4,4-dimethyl-3,4-dihydrochromeno[3,4-d]imidazole derivatives have been synthesized and their mPGES-1 biological activity has been disclosed in detail. Structure-activity relationship (SAR) optimization provided inhib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4c3194769e93c1e5b342652115b63fe7
https://doi.org/10.1016/j.bmcl.2017.03.068
https://doi.org/10.1016/j.bmcl.2017.03.068
Autor:
Satyawan Jadhav, Mahamadhanif S. Shaikh, Abhay Kulkarni, Mahamad Yunnus A. Mahat, Nagarajan Muthukaman, Srinivasa Honnegowda, Vidya Ganapati Kattige, Laxmikant Atmaram Gharat, Vikas Karande, Shital Tondlekar, Dnyandeo Pisal, Macchindra Tambe, Neelima Khairatkar-Joshi, Girish S. Gudi, Neelam Sarode, Sanjay Deshmukh
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:5977-5984
The discovery and SAR of potent, selective dioxane-fused tricyclic benz[ d ]imidazole derivatives as mPGES-1 inhibitor are herein described. Various amide modifications in this series afforded many potent mPGES-1 inhibitors, of which 17d proved to be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::74aee3215b596ce6b0bc05c3c26d7a00
https://doi.org/10.1016/j.bmcl.2016.10.079
https://doi.org/10.1016/j.bmcl.2016.10.079
Autor:
Nagarajan Muthukaman, Pooja Sawant, Dnyandeo Pisal, Srinivasa Honnegowda, Abhay Kulkarni, Vidya Ganapati Kattige, Sanjay Deshmukh, Shital Tondlekar, Neelam Sarode, Satyawan Jadhav, Neelima Khairatkar-Joshi, Dayanidhi Behera, Girish S. Gudi, Ramchandra R. Sangana, Vikas Karande, Macchindra Tambe, Monali Pisat, Mahamadhanif S. Shaikh, Laxmikant Atmaram Gharat
Publikováno v:
Bioorganicmedicinal chemistry letters. 28(7)
In an effort to identify CYP and hERG clean mPGES-1 inhibitors from the dihydrofuran-fused tricyclic benzo[d]imidazole series lead 7, an extensive structure-activity relationship (SAR) studies were performed. Optimization of A, D and E-rings in 7 aff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa34d823475ba2b669394baf70bf1665
https://pubmed.ncbi.nlm.nih.gov/29519738
https://pubmed.ncbi.nlm.nih.gov/29519738
Autor:
Vijayshree B. Avhad, Rajendra L. Harde, Ashwini A. Joshi, Megha Marathe, Malini Bajpai, Satyawan Jadhav, Mahamad Yunnus A. Mahat, Praveen Kumar Gupta, Sanjib Das, Neelima Khairatkar-Joshi, Maulik Nitinkumar Gandhi, Girish S. Gudi, Deepak K. Bhateja, Srinivas Gullapalli, Shelke Dnyaneshwar Eknath, A. P. Thomas
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 24:3238-3242
We report analogue-based rational design and synthesis of two novel series of polycyclic heteroarenes, pyrrolo[3,2-b]quinolines and pyrido[2,3-b]indoles, tethered to a biaryl system by a methyl-, ethyl- or propyl ether as PDE10A inhibitors. A number
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11a331b93cdbdc2cec527f194f2a9492
https://doi.org/10.1016/j.bmcl.2014.06.028
https://doi.org/10.1016/j.bmcl.2014.06.028
Autor:
Sanjib Das, Rajendra L. Harde, Dnyaneshwar E. Shelke, Neelima Khairatkar-Joshi, Malini Bajpai, Ratika S. Sapalya, Harshada V. Surve, Girish S. Gudi, Rambabu Pattem, Dayanidhi B. Behera, Satyawan B. Jadhav, Abraham Thomas
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 24:2073-2078
We report analogue-based rational design and synthesis of two novel series of polycyclic heteroarenes, pyrrolo[3,2-b]quinolines and pyrido[2,3-b]indoles, tethered to a biaryl system by a methyl-, ethyl- or propyl ether as PDE10A inhibitors. A number
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60965152c23ed1f746f77808eb30258a
https://doi.org/10.1016/j.bmcl.2014.03.054
https://doi.org/10.1016/j.bmcl.2014.03.054
Autor:
Dinesh Pradeep Wale, Anupindi Raghuram, Shobha S. Rao, Indranil Mukhopadhyay, Neelima Khairatkar-Joshi, Sachin Sundarlal Chaudhari, Pallavi V. Karnik, Thamil Selvan Vaiyapuri, Ashok Bhausaheb Kadam, A. P. Thomas, Ramchandra R. Sangana, Girish S. Gudi, Vikram Mansingh Bhosale
Publikováno v:
Bioorganic & Medicinal Chemistry. 21:6542-6553
A novel series of N -aryl-3,4-dihydro-1′ H -spiro[chromene-2,4′-piperidine]-1′-carboxamides was identified as transient receptor potential melastatin 8 (TRPM8) channel blockers through analogue-based rational design, synthesis and screening. De
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd11b1ba720961cef81452b38a0f1e30
https://doi.org/10.1016/j.bmc.2013.08.031
https://doi.org/10.1016/j.bmc.2013.08.031
Tricyclic 4,4-dimethyl-3,4-dihydrochromeno[3,4-d]imidazole derivatives as microsomal prostaglandin E
Autor:
Nagarajan, Muthukaman, Macchindra, Tambe, Mahamadhanif, Shaikh, Dnyandeo, Pisal, Sanjay, Deshmukh, Shital, Tondlekar, Neelam, Sarode, Lakshminarayana, Narayana, Jitendra M, Gajera, Vidya G, Kattige, Srinivasa, Honnegowda, Vikas, Karande, Abhay, Kulkarni, Dayanidhi, Behera, Satyawan B, Jadhav, Girish S, Gudi, Neelima, Khairatkar-Joshi, Laxmikant A, Gharat
Publikováno v:
Bioorganicmedicinal chemistry letters. 27(11)
A series of substituted tricyclic 4,4-dimethyl-3,4-dihydrochromeno[3,4-d]imidazole derivatives have been synthesized and their mPGES-1 biological activity has been disclosed in detail. Structure-activity relationship (SAR) optimization provided inhib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9874f5bf5efea64e8794baffe42a441c
https://pubmed.ncbi.nlm.nih.gov/28400234
https://pubmed.ncbi.nlm.nih.gov/28400234