CENP-E activation by Aurora A and B controls kinetochore fibrous corona disassembly

Autor: Susana Eibes, Girish Rajendraprasad, Claudia Guasch-Boldu, Mirela Kubat, Yulia Steblyanko, Marin Barisic

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)

Abstract Accurate chromosome segregation in mitosis depends on multiprotein structures called kinetochores that are built on the centromeric region of sister chromatids and serve to capture mitotic spindle microtubules. In early mitosis, unattached k

Externí odkaz: https://doaj.org/article/1daa5f4d16d84a39970aa15a6bcdca50

Chemogenetic profiling reveals PP2A‐independent cytotoxicity of proposed PP2A activators iHAP1 and DT‐061

Autor: Gianmatteo Vit, Joana Duro, Girish Rajendraprasad, Emil P T Hertz, Lya Katrine Kauffeldt Holland, Melanie Bianca Weisser, Brennan C McEwan, Blanca Lopez‐Mendez, Paula Sotelo‐Parrilla, A Arockia Jeyaprakash, Guillermo Montoya, Niels Mailand, Kenji Maeda, Arminja Kettenbach, Marin Barisic, Jakob Nilsson

Publikováno v: Vit, G, Duro, J, Rajendraprasad, G, Hertz, E P T, Holland, L K K, Weisser, M B, McEwan, B C, Lopez-Mendez, B, Sotelo-Parrilla, P, Jeyaprakash, A A, Montoya, G, Mailand, N, Maeda, K, Kettenbach, A, Barisic, M & Nilsson, J 2022, ' Chemogenetic profiling reveals PP2A-independent cytotoxicity of proposed PP2A activators iHAP1 and DT-061 ', EMBO Journal, vol. 41, no. 14, e110611 . https://doi.org/10.15252/embj.2022110611

Protein phosphatase 2A (PP2A) is an abundant phosphoprotein phosphatase that acts as a tumor suppressor. For this reason, compounds able to activate PP2A are attractive anticancer agents. The compounds iHAP1 and DT-061 have recently been reported to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17bdcd227aeee9bfe729ad771c85b7dc
https://doi.org/10.15252/embj.2022110611

Cellular toxicity of iHAP1 and DT-061 does not occur through PP2A-B56 targeting

Autor: Brennan C McEwan, Marin Barisic, Gianmatteo Vit, Blanca López-Méndez, Kenji Maeda, Jakob Nilsson, Guillermo Montoya, Arminja N. Kettenbach, Lya Katrine Kauffeldt Holland, Niels Mailand, Emil Peter Thrane Hertz, Girish Rajendraprasad, Joana Duro, Melanie Bianca Weisser

PP2A is an abundant phosphoprotein phosphatase that acts as a tumor suppressor. For this reason, compounds able to activate PP2A are attractive anticancer agents. The small molecule compounds iHAP1 and DT-061 have recently been reported by Leonard et

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::451c3956bfc6131e63300f7ccff8637b
https://doi.org/10.1101/2021.07.08.451586

Mitotic poleward flux: Finding balance between microtubule dynamics and sliding

Autor: Marin Barisic, Girish Rajendraprasad

Publikováno v: BioEssays : news and reviews in molecular, cellular and developmental biologyREFERENCES. 43(8)

Continuous poleward motion of microtubules in metazoan mitotic spindles has been fascinating generations of cell biologists over the last several decades. In human cells, this so-called poleward flux was recently shown to be driven by the coordinated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04a36dd1c6695a282387f2405aa23346
https://pubmed.ncbi.nlm.nih.gov/34085708

TH588 and low-dose nocodazole impair chromosome congression by suppressing microtubule turnover within the mitotic spindle

Autor: Girish Rajendraprasad, Susana Eibes, Marin Barisic, Claudia Guasch Boldú

Publikováno v: Rajendraprasad, G, Eibes, S, Boldú, C G & Barisic, M 2021, ' TH588 and low-dose nocodazole impair chromosome congression by suppressing microtubule turnover within the mitotic spindle ', Cancers, vol. 13, no. 23, 5995 . https://doi.org/10.3390/cancers13235995
Cancers
Cancers; Volume 13; Issue 23; Pages: 5995
Cancers, Vol 13, Iss 5995, p 5995 (2021)

Simple Summary A promising anti-cancer compound TH588 has been recently identified as a microtubule-targeting agent that inhibits tubulin polymerization in vitro and interferes with microtubule dynamics in interphase cells. Although it was shown to a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fbf4e32134400b6b09190eaf423a3ff
https://curis.ku.dk/portal/da/publications/th588-and-lowdose-nocodazole-impair-chromosome-congression-by-suppressing-microtubule-turnover-within-the-mitotic-spindle(5b4e3015-1347-489f-89b0-c92991da0499).html