Zobrazeno 1 - 10
of 77
pro vyhledávání: '"Girish C. Melkani"'
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-11 (2024)
Abstract The Drosophila model is pivotal in deciphering the pathophysiological underpinnings of various human ailments, notably aging and cardiovascular diseases. Cutting-edge imaging techniques and physiology yield vast high-resolution videos, deman
Externí odkaz:
https://doaj.org/article/9a2735648bfc4162997dade9bf85d443
Autor:
Jonathan R. Roth, Ruan Carlos Macedo de Moraes, Brittney P. Xu, Savannah R. Crawley, Malghalara A. Khan, Girish C. Melkani
Publikováno v:
Frontiers in Aging Neuroscience, Vol 15 (2023)
Huntington’s disease (HD) is a neurodegenerative disease characterized by movement and cognitive dysfunction. HD is caused by a CAG expansion in exon 1 of the HTT gene that leads to a polyglutamine (PQ) repeat in the huntingtin protein, which aggre
Externí odkaz:
https://doaj.org/article/798592d43c794b8684d6333d9ac38cd5
Autor:
Christopher Livelo, Yiming Guo, Farah Abou Daya, Vasanthi Rajasekaran, Shweta Varshney, Hiep D. Le, Stephen Barnes, Satchidananda Panda, Girish C. Melkani
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Time-restricted feeding (TRF) can prevent muscle function decline from obesogenic challenges. Here, the authors reveal that TRF improves muscle function through modulations of common and distinct pathways in diet- and genetic-induced obesity models.
Externí odkaz:
https://doaj.org/article/29aba1d470984473b243239171efc15c
Autor:
Jesús E. Villanueva, Christopher Livelo, Adriana S. Trujillo, Sahaana Chandran, Brendon Woodworth, Leo Andrade, Hiep D. Le, Uri Manor, Satchidananda Panda, Girish C. Melkani
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-5 (2020)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/c513ddba158548b69a4cadb4542d60f5
Autor:
Jesús E. Villanueva, Christopher Livelo, Adriana S. Trujillo, Sahaana Chandran, Brendon Woodworth, Leo Andrade, Hiep D. Le, Uri Manor, Satchidananda Panda, Girish C. Melkani
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Time-restricted feeding (TRF) has beneficial metabolic effects. Here the authors examine how TRF impacts muscle physiology using fly models of metabolically adverse conditions, including diet and genetic models of obesity as well as circadian rhythm
Externí odkaz:
https://doaj.org/article/c7eb88caeb7f43849647d5eef7935207
Autor:
Jennifer A. Suggs, Girish C. Melkani, Bernadette M. Glasheen, Mia M. Detor, Anju Melkani, Nathan P. Marsan, Douglas M. Swank, Sanford I. Bernstein
Publikováno v:
Disease Models & Mechanisms, Vol 10, Iss 6, Pp 761-771 (2017)
Individuals with inclusion body myopathy type 3 (IBM3) display congenital joint contractures with early-onset muscle weakness that becomes more severe in adulthood. The disease arises from an autosomal dominant point mutation causing an E706K substit
Externí odkaz:
https://doaj.org/article/0734f576d32c4449a6e56f15badb6a57
Publikováno v:
Obesity. 31:40-49
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8dfbf7196f7e00e4964bd401f0178721
https://doi.org/10.1002/oby.23664
https://doi.org/10.1002/oby.23664
Autor:
William A Kronert, Kaylyn M Bell, Meera C Viswanathan, Girish C Melkani, Adriana S Trujillo, Alice Huang, Anju Melkani, Anthony Cammarato, Douglas M Swank, Sanford I Bernstein
Publikováno v:
eLife, Vol 7 (2018)
K146N is a dominant mutation in human β-cardiac myosin heavy chain, which causes hypertrophic cardiomyopathy. We examined how Drosophila muscle responds to this mutation and integratively analyzed the biochemical, physiological and mechanical founda
Externí odkaz:
https://doaj.org/article/dd8e2172a5be473eaefc0eef1b630943
Autor:
Uri Manor, Sahaana Chandran, Girish C. Melkani, Jesús E. Villanueva, Christopher Livelo, Hiep D. Le, Brendon Woodworth, Satchidananda Panda, Leo Andrade, Adriana S. Trujillo
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-5 (2020)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e31988c8cc11d42f42d30df3620783a1
http://link.springer.com/article/10.1038/s41467-020-16193-w
http://link.springer.com/article/10.1038/s41467-020-16193-w
Publikováno v:
International Journal of Molecular Sciences. 24:422
Nearly 50% of adults will suffer from obesity in the U.S. by 2030. High obesity rates can lead to high economic and healthcare burdens in addition to elevated mortality rates and reduced health span in patients. Emerging data demonstrate that obesity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2765479f27453a24274edc760fa0dea
https://doi.org/10.3390/ijms24010422
https://doi.org/10.3390/ijms24010422