Zobrazeno 1 - 10
of 77
pro vyhledávání: '"Girish C Melkani"'
Autor:
William A Kronert, Kaylyn M Bell, Meera C Viswanathan, Girish C Melkani, Adriana S Trujillo, Alice Huang, Anju Melkani, Anthony Cammarato, Douglas M Swank, Sanford I Bernstein
Publikováno v:
eLife, Vol 7 (2018)
K146N is a dominant mutation in human β-cardiac myosin heavy chain, which causes hypertrophic cardiomyopathy. We examined how Drosophila muscle responds to this mutation and integratively analyzed the biochemical, physiological and mechanical founda
Externí odkaz:
https://doaj.org/article/dd8e2172a5be473eaefc0eef1b630943
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-11 (2024)
Abstract The Drosophila model is pivotal in deciphering the pathophysiological underpinnings of various human ailments, notably aging and cardiovascular diseases. Cutting-edge imaging techniques and physiology yield vast high-resolution videos, deman
Externí odkaz:
https://doaj.org/article/9a2735648bfc4162997dade9bf85d443
Autor:
Girish C Melkani, Adriana S Trujillo, Raul Ramos, Rolf Bodmer, Sanford I Bernstein, Karen Ocorr
Publikováno v:
PLoS Genetics, Vol 9, Iss 12, p e1004024 (2013)
Amyloid-like inclusions have been associated with Huntington's disease (HD), which is caused by expanded polyglutamine repeats in the Huntingtin protein. HD patients exhibit a high incidence of cardiovascular events, presumably as a result of accumul
Externí odkaz:
https://doaj.org/article/55a552eb5c7146c8a7ee58189893788d
Publikováno v:
PLoS ONE, Vol 6, Iss 7, p e22579 (2011)
UNC-45 is a UCS (UNC-45/CRO1/She4P) class chaperone necessary for myosin folding and/or accumulation, but its requirement for maintaining cardiac contractility has not been explored. Given the prevalence of myosin mutations in eliciting cardiomyopath
Externí odkaz:
https://doaj.org/article/f1f55cee6ee54e95b7b1530fe00380ee
Autor:
Jonathan R. Roth, Ruan Carlos Macedo de Moraes, Brittney P. Xu, Savannah R. Crawley, Malghalara A. Khan, Girish C. Melkani
Publikováno v:
Frontiers in Aging Neuroscience, Vol 15 (2023)
Huntington’s disease (HD) is a neurodegenerative disease characterized by movement and cognitive dysfunction. HD is caused by a CAG expansion in exon 1 of the HTT gene that leads to a polyglutamine (PQ) repeat in the huntingtin protein, which aggre
Externí odkaz:
https://doaj.org/article/798592d43c794b8684d6333d9ac38cd5
Autor:
Christopher Livelo, Yiming Guo, Farah Abou Daya, Vasanthi Rajasekaran, Shweta Varshney, Hiep D. Le, Stephen Barnes, Satchidananda Panda, Girish C. Melkani
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Time-restricted feeding (TRF) can prevent muscle function decline from obesogenic challenges. Here, the authors reveal that TRF improves muscle function through modulations of common and distinct pathways in diet- and genetic-induced obesity models.
Externí odkaz:
https://doaj.org/article/29aba1d470984473b243239171efc15c
Autor:
Jesús E. Villanueva, Christopher Livelo, Adriana S. Trujillo, Sahaana Chandran, Brendon Woodworth, Leo Andrade, Hiep D. Le, Uri Manor, Satchidananda Panda, Girish C. Melkani
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-5 (2020)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/c513ddba158548b69a4cadb4542d60f5
Autor:
Jesús E. Villanueva, Christopher Livelo, Adriana S. Trujillo, Sahaana Chandran, Brendon Woodworth, Leo Andrade, Hiep D. Le, Uri Manor, Satchidananda Panda, Girish C. Melkani
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Time-restricted feeding (TRF) has beneficial metabolic effects. Here the authors examine how TRF impacts muscle physiology using fly models of metabolically adverse conditions, including diet and genetic models of obesity as well as circadian rhythm
Externí odkaz:
https://doaj.org/article/c7eb88caeb7f43849647d5eef7935207
Publikováno v:
Obesity. 31:40-49
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8dfbf7196f7e00e4964bd401f0178721
https://doi.org/10.1002/oby.23664
https://doi.org/10.1002/oby.23664
Autor:
Uri Manor, Sahaana Chandran, Girish C. Melkani, Jesús E. Villanueva, Christopher Livelo, Hiep D. Le, Brendon Woodworth, Satchidananda Panda, Leo Andrade, Adriana S. Trujillo
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-5 (2020)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e31988c8cc11d42f42d30df3620783a1
http://link.springer.com/article/10.1038/s41467-020-16193-w
http://link.springer.com/article/10.1038/s41467-020-16193-w