Výsledky vyhledávání - "Girish A Hampannavar"

Akademický článek

Design, synthesis, and biological evaluation of novel diclofenac analogs as promising anti-inflammatory agents

Autor: Manjula K Chikkamath, Girish A Hampannavar, Mahesh B Palkar

Publikováno v: Indian Journal of Health Sciences and Biomedical Research KLEU, Vol 12, Iss 1, Pp 35-43 (2019)

INTRODUCTION: Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used as analgesics and antipyretics in the treatment of pain, fever, and rheumatoid arthritis. Major side effect with treatment of NSAIDs is gastric irritation. 1,3,4-thiadiazole

Externí odkaz: https://doaj.org/article/fb74048c131f4e498eca251183711162

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Synthesis of 4,6-disubstituted pyrazolo[3,4-d]pyrimidine analogues: Cyclin-dependent kinase 2 (CDK2) inhibition, molecular docking and anticancer evaluation

Autor: Rajkumar Banerjee, Srinivasulu Cherukupalli, Harikrishna Reddy Rachamalla, Nisar Sayyad, Rajshekhar Karpoormath, Balakumar Chandrasekaran, Rajeshwar Reddy Aleti, Girish A. Hampannavar, Srinivas Reddy Merugu

Publikováno v: Journal of Molecular Structure. 1176:538-551

The cyclin-dependent kinases (CDKs) play a crucial role in cell cycle progression and are validated targets of cancer therapy. Pyrazolopyrimidines are versatile scaffolds, which have been exploited for developing potential anticancer agents. We herei

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8c09e694e530d177946fdd647a695900
https://doi.org/10.1016/j.molstruc.2018.08.104

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An appraisal on synthetic and pharmaceutical perspectives of pyrazolo[4,3-d]pyrimidine scaffold

Autor: Francis Kayamba, Rajeshwar Reddy Aleti, Nisar Sayyad, Sampath Chinnam, Girish A. Hampannavar, Balakumar Chandrasekaran, Rajshekhar Karpoormath, Srinivasulu Cherukupalli

Publikováno v: Bioorganic & Medicinal Chemistry. 26:309-339

Pyrazolo[4,3-d]pyrimidine, a fused heterocycle bearing pyrazole and pyrimidine portions has gained a significant attention in the field of bioorganic and medicinal chemistry. Pyrazolo[4,3-d]pyrimidine derivatives have demonstrated numerous pharmacolo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e181f32cc48e6b6bde2a854e705f328f
https://doi.org/10.1016/j.bmc.2017.10.012

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Ligand- and structure-basedin silicostudies to identify kinesin spindle protein (KSP) inhibitors as potential anticancer agents

Autor: Mahmoud E. S. Soliman, Chandrasekaran Balakumar, Nisar Sayyad, Frank Kozielski, Girish A. Hampannavar, Chuin Lean Tham, Rajshekhar Karpoormath, Samukelisiwe Pretty Khathi, Muthusamy Ramesh, Cherukupalli Srinivasulu

Publikováno v: Journal of Biomolecular Structure and Dynamics. 36:3687-3704

Kinesin spindle protein (KSP) belongs to the kinesin superfamily of microtubule-based motor proteins. KSP is responsible for the establishment of the bipolar mitotic spindle which mediates cell division. Inhibition of KSP expedites the blockade of th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::622050c6d22c8f3d8370c7fffb283582
https://doi.org/10.1080/07391102.2017.1396255

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Design, synthesis and QSAR studies of 2-amino benzo[d]thiazolyl substituted pyrazol-5-ones: novel class of promising antibacterial agents

Autor: Mange Ram Yadav, Girish A. Hampannavar, Mahesh B. Palkar, Aniket Patil, Harun M. Patel, Mahamadhanif S. Shaikh, Rajshekhar Karpoormath, Ashish M. Kanhed

Publikováno v: Medicinal Chemistry Research. 26:1969-1987

Novel analogs of 3-(4-substituted benzylideneamino)-N-(6-substituted-1,3-benzo[d]thiazol-2-yl)-4,5-dihydro-5-oxo-pyrazole-1-carboxamide (5a–s) were designed and synthesized by reacting 3-amino-N-(6-substituted-1,3-benzo[d]thiazol-2-yl)-4,5-dihydro-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::33982bec7b0c9231f6a82db2d2c0b642
https://doi.org/10.1007/s00044-017-1898-6

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Discovery of novel N-methyl carbazole tethered rhodanine derivatives as direct inhibitors of Mycobacterium tuberculosis InhA

Autor: Rajshekhar Karpoormath, Girish A. Hampannavar, Nikhil Agrawal, Mahesh B. Palkar, Balakumar Chandrasekaran, Ashish M. Kanhed, Mahamadhanif S. Shaikh, Christian Lherbet

Publikováno v: Bioorganic and Medicinal Chemistry Letters
Bioorganic and Medicinal Chemistry Letters, 2019, 29, pp.2338-2344. ⟨10.1016/j.bmcl.2019.06.015⟩
Bioorganic and Medicinal Chemistry Letters, Elsevier, 2019, 29, pp.2338-2344. ⟨10.1016/j.bmcl.2019.06.015⟩

International audience; InhA (Enoyl-ACP reductase) plays a crucial role in the biosynthetic pathway of cell wall synthesis in Mycobacterium tuberculosis (Mtb). Isoniazid (INH) is an important firstline drug, which inhibits InhA. The rapid increase in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02641c2597114df8e6d9614794ea2a3f
https://hal.science/hal-03038682/document

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Novel series of benzo[d]thiazolyl substituted-2-quinolone hybrids: Design, synthesis, biological evaluation and in-silico insights

Autor: Girish Bolakatti, Mahesh B. Palkar, Arvind Badiger, Girish A. Hampannavar, Shilpa Ninganagouda, Rajshekhar Karpoormath, Manjunatha S. Katagi

Publikováno v: Journal of Molecular Structure. 1227:129413

A novel series of 3-(2-(4-(substituted-benzo[d]thiazol-2-yl)phenylamino)acetyl)-4‑hydroxy-1-methyl/phenyl quinolin-2(1H)-one (7a-f and 8a-f) were synthesized. Reaction of appropriately substituted-2-(4-amino phenyl)benzo[d]thiazole (4a-f) with 3-(2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ea0f13fb0cd88be6fe205384141a3202
https://doi.org/10.1016/j.molstruc.2020.129413

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Current Perspective of Natural Alkaloid Carbazole and its Derivatives as Antitumor Agents

Autor: A.M. Faya, Mahamadhanif S. Shaikh, Kavita S. Jain, Rajshekhar Karpoormath, Harun M. Patel, Girish A. Hampannavar, Neeta Thapliyal, Rajesh A. Rane, Wesam S. Alwan, Mahesh B. Palkar

Publikováno v: Anti-Cancer Agents in Medicinal Chemistry. 15:1049-1065

Throughout our evolution, the importance of natural products for medicine and health has been increasing and it continues to be a key source of novel anticancer drugs, leads and new chemical entities. Among natural products, tricyclic heteroaromatic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a615ceda4e09e2a08762674d90757c79
https://doi.org/10.2174/1871520615666150113105405

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An Insight into Purine, Tyrosine and Tryptophan Derived Marine Antineoplastic Alkaloids

Autor: Kavita S. Jain, Harun M. Patel, Neeta Thapliyal, Mahesh B. Palkar, Wesam S. Alwan, Sivanandhan Karunanidhi, Girish A. Hampannavar, Rajesh A. Rane, Mahamadhanif S. Shaikh, Rajshekhar Karpoormath

Publikováno v: Anti-Cancer Agents in Medicinal Chemistry. 15:947-954

There is an ever-increasing need for the development of new drugs with safe and improved profile for the treatment of cancer. From time immemorial, nature has been considered as an abundant source of medicinal compounds having therapeutic properties.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::616186e27fd0d8f378803d7a66c4c6d9
https://doi.org/10.2174/1871520615666150101143520

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